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Familial risks in nervous system tumors

We used the nationwide Swedish Family-Cancer Database to analyze the risk for nervous system tumors in offspring through parental and sibling probands. Among 0-68-year-old offspring, close to 11000 patients with a nervous system tumor were identified in years 1961 to 2000, among whom 199 had a parent diagnosed with a nervous system tumor. Brain tumors constituted 86% of all tumors, and astrocytoma

Second primary cancers after sporadic and familial colorectal cancer

Second cancers were studied among 68,104 cases of colorectal cancer (CRC) from the Swedish Family-Cancer Database. A total of 1,113 patients received a diagnosis of second CRC; 25 of them had a family history of CRC. Cases of second CRC with a family history were diagnosed up to 10 years before sporadic cases. The relative risk (RR) of all second CRCs was 2.21 compared with the first CRC. Familial

Recommendations for Deprescribing of Medication in the Last Phase of Life : An International Delphi Study

Context: Medications may become inappropriate for patients in the last phase of life and may even compromise their quality of life. Objective: To find consensus on recommendations regarding deprescribing of medications for adult patients with a life expectancy of six months or less. Methods: Experts working in palliative care or other relevant disciplines were asked to participate in this internat

European Resuscitation Council and European Society of Intensive Care Medicine guidelines 2021 : post-resuscitation care

The European Resuscitation Council (ERC) and the European Society of Intensive Care Medicine (ESICM) have collaborated to produce these post-resuscitation care guidelines for adults, which are based on the 2020 International Consensus on Cardiopulmonary Resuscitation Science with Treatment Recommendations. The topics covered include the post-cardiac arrest syndrome, diagnosis of cause of cardiac a

Altered Tryptophan Catabolism in Placentas From Women With Pre-eclampsia

Background: The kynurenine pathway enzymes, breaking down tryptophan, are abundant in placental tissue. These metabolites are involved in immunoregulatory mechanisms, although the role of this pathway in pre-eclampsia (PE) has only begun to be characterized. Here, we determined tryptophan and metabolite levels together with the expression of kynurenine pathway enzymes and inflammatory factors in p

Artificial intelligence together with mechanical imaging in mammography

Artificial intelligence (AI) applications are increasingly seeing use in breast imaging, particularly to assist in or automate the reading of mammograms. Another novel technique is mechanical imaging (MI) which estimates the relative stiffness of suspicious breast abnormalities by measuring the distribution of pressure on the compressed breast. This study investigates the feasibility of combining

GFAp and tau protein as predictors of neurological outcome after out-of-hospital cardiac arrest : A post hoc analysis of the COMACARE trial

Aim: To determine the ability of serum glial fibrillary acidic protein (GFAp) and tau protein to predict neurological outcome after out-of-hospital cardiac arrest (OHCA). Methods: We measured plasma concentrations of GFAp and tau of patients included in the previously published COMACARE trial (NCT02698917) on intensive care unit admission and at 24, 48, and 72 h after OHCA, and compared them to ne

High levels of mitochondrial DNA are associated with adolescent brain structural hypoconnectivity and increased anxiety but not depression

Background: Adolescent anxiety and depression are highly prevalent psychiatric disorders that are associated with altered molecular and neurocircuit profiles. Recently, increased mitochondrial DNA copy number (mtDNA-cn) has been found to be associated with several psychopathologies in adults, especially anxiety and depression. The associations between mtDNA-cn and anxiety and depression have not,

Ptychographic Nano-Analytical Microscope (PtyNAMi) at PETRA III : Signal-to-background optimization for imaging with high sensitivity

The X-ray scanning microscope PtyNAMi at beamline P06 of PETRA III at DESY in Hamburg, Germany, is designed for high-spatial-resolution 3D imaging with high sensitivity. Besides optimizing the coherent ux density on the sample and the precision mechanics of the scanner, special care has been taken to reduce background signals on the detector. The optical path behind the sample is evacuated up unti

Cellular alterations identified in pluripotent stem cell-derived midbrain spheroids generated from a female patient with progressive external ophthalmoplegia and parkinsonism who carries a novel variation (p.Q811R) in the POLG1 gene

Variations in the POLG1 gene encoding the catalytic subunit of the mitochondrial DNA polymerase gamma, have recently been associated with Parkinson's disease (PD), especially in patients diagnosed with progressive external ophthalmoplegia (PEO). However, the majority of the studies reporting this association mainly focused on the genetic identification of the variation in POLG1 in PD patient prima

Circular RNAs to predict clinical outcome after cardiac arrest

Background: Cardiac arrest (CA) represents the third leading cause of death worldwide. Among patients resuscitated and admitted to hospital, death and severe neurological sequelae are frequent but difficult to predict. Blood biomarkers offer clinicians the potential to improve prognostication. Previous studies suggest that circulating non-coding RNAs constitute a reservoir of novel biomarkers. The

GATA2 at the mitosis-to-G1 transition is critical for definitive hematopoiesis

In mitosis, transcription factors (TFs) and RNA polymerase disperse across the cytoplasm leading to transcriptional silencing, but some TFs are retained on condensed chromatin and mark genomic sites, a mechanism termed mitotic bookmarking. In pluripotent and differentiated cells this mechanism is important for pluripotency maintenance, cell reprogramming and lineage inheritance. However, the role

Clinical insights into small cell lung cancer : Tumor heterogeneity, diagnosis, therapy, and future directions

Small cell lung cancer (SCLC) is characterized by rapid growth and high metastatic capacity. It has strong epidemiologic and biologic links to tobacco carcinogens. Although the majority of SCLCs exhibit neuroendocrine features, an important subset of tumors lacks these properties. Genomic profiling of SCLC reveals genetic instability, almost universal inactivation of the tumor suppressor genes TP5

Comparison of four clinical risk scores in comatose patients after out-of-hospital cardiac arrest

Background and aims: Several different scoring systems for early risk stratification after out-of-hospital cardiac arrest have been developed, but few have been validated in large datasets. The aim of the present study was to compare the well-validated Out-of-hospital Cardiac Arrest (OHCA) and Cardiac Arrest Hospital Prognosis (CAHP)-scores to the less complex MIRACLE2- and Target Temperature Mana

List Of Scholarships And Grant 250212

List of scholarships and grants Page 1 of 76 List of scholarships and grants – offered by foundations connected with Lund University Finance Endowment administration Emma Haverlind, administrator 2025-02-12 Postal address Box 117, 221 00 Visiting address Sandgatan 5 Telephone +46 222 71 44, +46 46 222 00 00 E-mail stipendier@eken.lu.se Website www.lunduniversity.lu.se, www.staff.lu.se Page 2 of 76

https://www.staff.lu.se/sites/staff.lu.se/files/2025-02/List%20of%20scholarships%20and%20grant%20250212.pdf - 2026-05-28

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LUNDS UNIVERSITET PROTOKOLL Sammanträde 23 september 2022 kl. 10.15 - 12:00 Hybridmöte i 8538 och på internet via Zoom, mötes-id: 69041036943 Dnr: STYR 2022/1836 Filosofiska institutionen I nstitutionsstyrelsen Närvarande: Ledamöter: Tobias Hansson Wahlberg Sonja Helmer Martin Jönsson Aaron Milz Mathias Osvath Tomas Persson Björn Petersson Toni Rennow-Rasmussen Jakob Stcnsekc Betty Tärning Ylva vo

https://www.fil.lu.se/fileadmin/user_upload/fil/dokument/Protokoll_styrelsemoete/2022/Protokoll_2022-09-23.pdf - 2026-05-25

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https://www.folklivsarkivet.lu.se/fileadmin/user_upload/folklivsarkivet/Musiksamlingarna_webb/Dokument/Parm_4_C.pdf - 2026-05-25

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LUNDS UNIVERSITET Humanistiska och teologiska fakulteterna Fors kn i ngs na m nden Fakultetssekreterare Martin Degrell Narvarande Iedamoter Niclas Burenhult PROTO KOLL Sammantriidestid 2024-02-13, kl. 9.15-11.15 docent Anamaria Dutceac Segesten Sanne Krogh Groth docent docent ordforande Paul Tenngart Molly Uhlmann Lindberg Johan Ostling docent doktorand professor Ovriga narvarande Martin Degrell f

https://www.ht.lu.se/fileadmin/user_upload/ht/dokument/Fakulteterna/protokoll/FON/Protokoll_FON_2024.pdf - 2026-05-25