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Eighty basal cell carcinomas (BCCs) in 21 patients, 10 lesions of Bowen's disease in three patients, and four lesions of cutaneous T-cell lymphoma in two patients, were treated with photodynamic laser therapy (PDT), using topical application of the haem precursor delta-amino levulinic acid (ALA). The diagnoses were confirmed histologically prior to treatment. Fifty-five of the BCCs were superficia
Recent findings have indicated that tyrosine kinase inhibitors (TKIs) targeting the ERBB receptor family display anti-leukaemic effects, despite the lack of receptor expression on human leukaemic cells. The occurrence of activating mutations in the gene encoding FMS-like tyrosine kinase 3 (FLT3) in patients with acute myeloid leukaemia (AML) has rendered inhibition of this receptor a promising the
Cap rock integrity is an essential characteristic of any reservoir to be used for long-term CO 2 storage. Seismic AVOA (amplitude variation with offset and azimuth) techniques have been applied to map HTI anisotropy near the cap rock of the Weyburn field in southeast Saskatchewan, Canada, with the purpose of identifying potential fracture zones that may compromise seal integrity. This analysis, su
Lumbar puncture (LP) is increasingly performed in memory clinics. We investigated patient-acceptance of LP, incidence of and risk factors for post-LP complications in memory clinic populations.
The prevalence of obesity is increasing in Iran. Previous studies showed mixed results in relation to association between socioeconomic status and obesity in the country. The current study aimed to examine educational inequalities among adults in Tehran in 2011.
MicroRNAs are central players in the control of insulin secretion, but their transcriptional regulation is poorly understood. Our aim was to investigate cAMP-mediated transcriptional regulation of the miR-212/miR-132 cluster and involvement of further upstream proteins in insulin secreting β-cells. cAMP induced by forskolin+IBMX or GLP-1 caused increased expression of miR-212/miR-132, and elevated
OBJECTIVES: The aim of this study was to examine whether three main definitions of the metabolic syndrome (MetS) - WHO, National Cholesterol Education Program-Adult Treatment Panel III and International Diabetes Federation - identify the same individuals and are able to predict incident myocardial infarction (MI) in families with essential hypertension. METHODS: The tested definitions were prospec
This unit provides detailed protocols for establishing rodent models of L-DOPA-induced dyskinesia. The 6-hydroxydopamine (6-OHDA) lesion procedure is described in more detail for mice than for rats since the lesioning procedure in rats has been described extensively in previous work and is less difficult to perform. Unlike primate models, rodent models of L-DOPA-induced dyskinesia are relatively s
Why was Scandinavia the first place in the world to introduce national laws allowing registered partnership between same-sex couples? This article is a survey and historical documentation of the registered partnership laws throughout Scandinavia, documenting their origin in Denmark in 1989 and their subsequent adoption by every Nordic country. The origins of the laws are traced to the 1970s
Genetic variation in the cluster on chromosome 15, encoding the nicotinic acetylcholine receptor subunits (CHRNA5-CHRNA3-CHRNB4), has shown strong associations with tobacco consumption and an additional risk increase in smoking-related diseases such as chronic obstructive pulmonary disease (COPD), peripheral artery disease and lung cancer.
Aims and objectives. To explore the development over time of beliefs about health, illness and health care in migrant women with gestational diabetes mellitus born in the Middle East and living in Sweden and to study the influence on self-care and care seeking. Background. With today's extensive global migration, contact with the new society/health care confronts the migrant's culture of origin wi
Purpose: Intensity modulated arc therapy (IMAT) is commonly used to treat prostate cancer. The purpose of this study was to evaluate the impact of leaf width and plan complexity on dynamic multileaf collimator (DMLC) tracking for prostate motion management during IMAT treatments. Methods: Prostate IMAT plans were delivered with either a high-definition MLC (HDMLC) or a Millennium MLC (M-MLC) (0.25
Purpose: The relative biological effectiveness of two epithermal neutron sources, a reactor based source at Studsvik, Sweden, and a proton accelerator-based source in Birmingham, UK, was studied in relation to the proportional absorbed dose distribution as a function of neutron energy. Evidence for any interactions between the effects of biological damage induced by high- and low-linear energy tra
BACKGROUND: 4-hydroxychlorothalonil (HCT, R182281), a transformation product of the fungicide chlorothalonil, was recently identified in human serum and breast milk. There are indications that HCT may be more toxic and environmentally persistent than chlorothalonil.OBJECTIVE: Our aim was to investigate serum concentrations of HCT in pregnant women in Sweden and Costa Rica.METHODS: We developed a q
Contributing to the growing interest in multiperspectival border studies, this article advocates for a re-centring of subaltern geopolitics in the debate. Focusing empirically on Morocco's diplomatic dispute with the EU over the application of trade agreements to the Western Sahara (2015–2019), the analysis considers the geopolitical bordering of the controversy through the concepts of dependency
Background: Despite proven benefits of exercise-based cardiac rehabilitation (EBCR), few patients with myocardial infarction (MI) participate in and complete these programs. Study design and objectives: The Remote Exercise SWEDEHEART study is a large multicenter registry-based cluster randomized crossover clinical trial with a planned enrollment of 1500 patients with a recent MI. Patients at inter
Introduction: Occupational balance is a fundamental concept that plays an influential role in enhancing health and well-being. Method: The Persian Occupational Balance Questionnaire-11 was administered to 157 healthy individuals in the test phase and 80 healthy individuals in the retest phase. Floor or ceiling effects, construct validity, discriminant validity, internal consistency reliability, te
