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Aim: The Cockcroft-Gault (CG) creatinine-based equation is still used to estimate glomerular filtration rate (eGFR) for drug dosage adjustment. Incorrect eGFR may lead to hazardous over- or underdosing. Methods: In a cross-sectional analysis, CG was validated against measured GFR (mGFR) in 14 804 participants and compared with the Modification-of-Diet-in-Renal-Diseases (MDRD), Chronic-Kidney-Disea
Although capacity development has been a key aspect of global aid policy for decades, success is limited. Capacity development is defined as a process, based on a partnership, to develop capacity to achieve a goal. The purpose of this thesis is to increase our understanding of why capacity development does not work as intended, and to inform the discussion on addressing the challenges. Two researc
Background: Sexual violence is widespread in war-torn North Kivu province in the Democratic Republic of the Congo (DRC). Timely access to care is crucial for the healing and wellbeing of survivors of sexual violence, but is problematic due to a variety of barriers. Through a better understanding of care-seeking behaviours and factors influencing timely access to care, programmes can be adapted to
When a course is designed, it is common to do it for a typical group of students, considered to represent “the majority”, the “norm” or the “average”. The concept of “edges” challenges this view: given the multiple dimensions that teaching and learning encompass, there will always be students who do not belong to a norm and will end up on an edge if they are not included in the course design. In t
REPLIK DN DEBATT 20/4.Fem Lunda-forskare: Modern forskning som direkt mäter koldioxidutbytet mellan skog och atmosfär visar att gamla skogar fortsätter att ta upp och binda koldioxid.Detta är en opinionstext i Dagens Nyheter. Skribenten svarar för åsikter i artikeln.
The system dynamics technique has been demonstrated to be a proper method by which to model and simulate the development of spatial data infrastructures (SDI). An SDI is a collaborative effort to manage and share spatial data at different political and administrative levels. It is comprised of various dynamically interacting quantitative and qualitative (linguistic) variables. To incorporate lingu
Self-adaptive software systems are designed to support a number of alternative solutions for fulfilling their requirements. These define an adaptation space. During operation, a self-adaptive system monitors its performance and when it finds that its requirements are not fulfilled, searches its adaptation space to select a best adaptation. Two major problems need to be addressed during the selecti
Synergies are frequently cited as a primary rationale for mergers and acquisitions, yet they are often overestimated in the pre-acquisition phase and inadequately translated into realised value. While prior research has extensively examined the financial valuation of synergies, less attention has been given to the organisational processes through which synergies are identified, evaluated and commu
BACKGROUND: Fever is associated with brain injury after cardiac arrest. It is unknown whether fever management with a feedback-controlled device impacts patient-centered outcomes in cardiac arrest patients. This trial aims to investigate fever management with or without a temperature control device after out-of-hospital cardiac arrest. METHODS: The TEMP-CARE trial is part of the 2 × 2 × 2 factoria
Carotid sinus massage (CSM) is essential in evaluating recurrent unexplained reflex syncope, as it uniquely identifies cardioinhibitory forms that other tests may miss. CSM is largely underused in clinical practice outside dedicated syncope facilities and, when performed, its execution varies, as does the interpretation of results. Underuse affects the diagnostic yield of CSM in the syncope evalua
The purpose of this project was to find estimates of the operational releases of 14C and 3H from new SMR technology that is being considered in Sweden, namely the Rolls-Royce SMR and the GE-Hitachi BWRX-300. To achieve this goal, models of the reactors of interest were made in the continuous-energy Monte-Carlo neutron and photon transport code Serpent, where the production of 14C and 3H could then
Infant Acute Lymphoblastic Leukemia (ALL) driven by the KMT2A::AFF1 onco-fusion is an aggressive, poor prognosis disease with few co-operative mutations. The fusion originates in utero, yet the embryonic initiating steps of disease development remain poorly understood. Here, we present a novel murine KMT2A::AFF1 model, that provides key insights into KMT2A::AFF1 pre-leukemia, relevant to human dis
