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This research examines the relationship between the language attitudes and language strategies of balanced Latvian-Russian bilinguals in Latvia, in the context of the country’s language policies, which shifted towards securitisation following the outbreak of the Russia-Ukraine war in 2022. To this end, the study proposes an explanatory model in which identity negotiation serves as the key med
Complement factor D (FD) (adipsin), is an adipokine essential for the activation of the complement alternative pathway (AP), contributing to inflammation but also to metabolic homeostasis through C3a production. We investigated the metabolic regulation of Cfd expression in mouse models. A diet-induced model of insulin resistance reduced expression of key AP components, including adipose Cfd, hepat
Hen egg-white lysozyme (HEWL) is a widely used model protein in crystallographic studies and its enzymatic mechanism has been extensively investigated for decades. Despite this, the interaction between the reaction intermediate and the catalytic Asp52, as well as the orientation of Asn44 and Asn46 side chains, remain ambiguous. Here, we report the crystal structures of perdeuterated HEWL and D2O b
Serum Amyloid A (SAA) proteins are acute-phase reactants with critical roles in sterile and bacterial inflammation. Through in vitro and in vivo experiments, we demonstrate that SAA proteins amplify cytokine and chemokine responses during sterile inflammation and enhance bacterial clearance in infectious conditions. Mechanistically, SAA proteins augment NF-κB signaling, driving pro and anti-in
Background: While energy communities working on electricity provision have been extensively studied, thermal energy communities (TECs) focusing on bringing district heating (DH) systems to decarbonise heat systems in buildings have been relatively under-researched. This study addresses this gap by presenting the first comprehensive examination of key factors influencing the emergence and developme
Nonlinear phenomena (NLP) are often associated with high arousal and function to grab attention and/or signal urgency in vocalizations such as distress calls. Although biomechanical models and in vivo/ex vivo experiments suggest that their occurrence reflects the destabilization of vocal fold vibration under intense subglottal pressure and muscle tension, comprehensive descriptions of the dynamics
The EU AI Act aims to regulate artificial intelligence (AI) in a way that balances innovation and protection from harms, but faces the challenge of keeping pace with the development of AI. This paper examines the tension between fixity and flexibility when regulating AI in the EU by drawing on literature on the pacing problem and anticipatory governance, contrasted by sociolegal theory on the impo
In July 2020, two Holocaust memorials disappeared from a Jewish cemetery in Stockholm where Holocaust survivors who died soon after coming to Sweden for medical treatment in 1945 are buried. Though it occurred in the midst of both the global #TakeItDown movement and the Swedish government’s plans to establish a Holocaust museum in Sweden, this removal garnered no media attention or public outcry.
For decades, extensive surfactant libraries have been developed to meet the requirements of downstream applications. However, achieving functional diversity has traditionally demanded a vast array of chemical motifs and synthetic pathways. Herein, a new approach for surfactant design based on structural isomerism is utilised to access a wide spectrum of functionalities. A library of C18-aliphatic
The orientation of juvenile marsh warblers during autumn migration was investigated at two widely different latitudes, in Sweden and in Kenya, by cage experiments in manipulated magnetic fields during the twilight period after sunset. The objective was to compare responses by birds exposed to different geomagnetic conditions, particularly to the shift in magnetic inclination between the northern a
I study the economic returns to migration among Swedish immigrants in the United States in 1900 and 1910, by social class. Using linked data from full-count Swedish and US censuses via the Swedish Emigrant Register, I first estimate the rates of return to migration using two identification strategies, with the returns exceeding 60 percent, notably higher for migrants from lower social classes. Fur
This paper examines how India’s national urban development agenda is reshaping relationships between national, State and city-level governments. Jawaharlal Nehru National Urban Renewal Mission, the flagship programme that heralded a new era of urban investment in India, contained a range of key governance aspirations: linking the analysis of urban poverty to city-level planning, developing holisti
Expanded state-subsidised housing programmes in middle-income countries raise questions about the displacement and socio-spatial marginalisation of poor households. Examining these questions through people’s experiences of resettlement indicates the importance of mobility to their lives. Drawing on a mixed-method comparative study of Ahmedabad, Chennai and Johannesburg, we ask: How does the reloca
This paper investigates online gender-based violence (OGBV) in China using the perspectives of queer feminism and cyberfeminism. As a case study, it examines the cyberviolence against the “Pink Hair Girl” on Xiaohongshu (a popular Chinese social media platform) and the subsequent resistance by women. The study focuses on the following questions: How does the symbolic use of pink hair represent que
Understanding the hydromechanical behavior of porous media such as sandstones is critical to various geoengineering applications such as geologic carbon storage, geothermal projects, oil and gas production and environmental remediation in aquifers. In these contexts, accurate quantification of the constitutive hydromechanical behavior of sandstones is necessary to predict reservoir responses. In t
Introduction: Acinetobacter baumannii is a gram-negative opportunistic bacterium that causes life-threatening infections in immunocompromised hosts. The complement system is a critical mechanism of innate immunity that protects the human body from bacterial infections. Complement activation leads to the deposition of the membrane attack complex (MAC), which can directly lyse gramnegative bacteria.
