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This study assesses effect of Japanese policies that can realize agglomeration against change of employment of Japanese manufacturing. It firstly identifies three precursors of agglomeration from literature review: network of similar companies, organizations with world-class technology and organizations with big demand. It then theorizes agglomeration factors induced by the precursors as well as f
Urokinase, a serine protease, catalyzes the conversion of plasminogen to plasmin, which is responsible for dissolution of clots in blood vessels. It is an important drug for treatment of thromboembolic disease. Production of urokinase by mammalian cell culture has the following important steps: synthesis, regulation and secretion. Production and accumulation of this product in a bioreactor is a re
The Wilms tumor gene (WT1) encodes a zinc-finger containing transcription factor present in primitive hematopoietic progenitor cells. WT1 is also highly expressed in most cases of acute myeloid leukemia. Moreover, WT1 can interfere with induced differentiation of leukemic cell lines. These data suggest a function of WT1 in the maintenance of a primitive phenotype and a role in leukemogenesis by in
Background Limited information is available regarding genetic contributions to valvular calcification, which is an important precursor of clinical valve disease. Methods We determined genomewide associations with the presence of aortic-valve calcification (among 6942 participants) and mitral annular calcification (among 3795 participants), as detected by computed tomographic (CT) scanning; the stu
The current expansion of mergers and acquisitions forces new postmerged organizational cultures to take form, and requires solid strategies for handling that procedure. Research indicate that at least half of all mergers fail in creating expected synergies, and that the reason for failing is assumed integration issues such as culture clashes. Creating a strong organizational culture is often appoi
PURPOSE: To estimate the effect of dexamethasone eye drops on the risk of progression from type 2 retinopathy of prematurity (ROP) to ROP requiring traditional treatments.DESIGN: Register-based cohort study.PARTICIPANTS: Preterm infants born before 30 weeks' gestation from 2015-2018 (control years) and from 2020-2021 (intervention years) registered in the Swedish Quality Register for ROP at 4 Swed
This article examines the methodological issues of structuring the diplomatic law of international organizations, its place in the system of international law. The interdisciplinary nature of the diplomatic law of international organizations, its relationship with diplomatic and consular law and the law of international organizations has been disclosed. An emphasis is given to the main features an
Monoclonal antibody solutions are set to become a major therapeutic tool in the years to come, capable of targeting various diseases by clever design of their antigen binding site. However, the formulation of stable solutions suitable for patient self-administration typically presents challenges, as a result of the increase in viscosity that often occurs at high concentrations. Here, we establish
X-ray ptychography is often implemented for nanoimaging at synchrotron radiation sources and extensions are being developed to make experiments faster. This work is on multi-beam ptychography with Fresnel zone plates that have a small lateral separation, enabling the imaging of an extended field of view without increasing exposure time. Sectional zone inversion is implemented for coding respective
α-Synuclein is a synaptic protein that accumulates primarily in synucleinopathies and secondarily in certain lysosomal storage disorders. However, its physiological roles in health and disease are not fully understood. In part, this has been hampered by the inability to visualize α-synuclein and its cellular localization, due to the lack of specific antibodies and faithful reporters. Here, we used
The use of standards has permeated virtually all aspects of modern society. Standards should be seen as the combined result of the standardisers’ expertise and the effects of the dynamics of the standardisation process itself. This article explores why some participants are more influential in standards development than others. Using an insider perspective, observations are gathered from almost a
Background T-cell activation and clonal expansion are essential to effective immunotherapy responses in non-small cell lung cancer (NSCLC). The distribution of T-cell clones may offer insights into immunogenic mechanisms and imply potential prognostic and predictive information. Methods We analyzed α/β T-cell receptor (TCR) clonality using RNA-sequencing of bulk frozen tumor tissue from 182 patien
We have used approximately 40 fs pulses from a Ti:sapphire laser to investigate the ultrafast energy transfer and relaxation dynamics in the light-harvesting pigment-proteins of photosynthetic purple bacteria. Our results reveal two new features, not earlier observed in light-harvesting pigments: (1) ultrafast relaxation characterized by a time constant of approximately 20 fs, which we interpret a
What is the effect of punching holes at random in an infinite tensed membrane? When will the membrane still support tension? This problem was introduced by Connelly in connection with applications of rigidity theory to natural sciences. The answer clearly depends on the shapes and the distribution of the holes. We briefly outline a mathematical theory of tension based on graph rigidity theory and
Pain, use of painkillers and alcohol are highly prevalent in the general population. Aims of the study were to describe differences in pain, alcohol consumption and use of painkillers among two 60 year old birth cohorts stratified by gender. Participants were recruited from the Skåne centre of The Swedish National study on Aging and Care, a multicentre, prospective, longitudinal study. The sample
The article seeks to further our understanding of the process of organizing nascent social ventures. It builds upon current research on the political and collaborative nature of the social entrepreneurial process, and takes an ANT-inspired processual approach to follow the organizational practices carried by a nascent social venture in its efforts to mobilize stakeholders, bring about collaboratio
Background: Several aggregate data meta-analyses have provided estimates of the effectiveness of influenza vaccination in community-dwelling elderly people. However, these studies ignored the effects of patient-level confounders such as sex, age, and chronic diseases that could bias effectiveness estimates. We aimed to assess the confounder-adjusted effectiveness of influenza vaccines on laborator
BACKGROUND: A gel-free proteomic approach was utilized to perform in-depth tissue protein profiling of lung adenocarcinoma (ADC) and normal lung tissues from early and advanced stages of the disease. The long-term goal of this study is to generate a large-scale, label-free proteomics dataset from histologically well-classified lung ADC that can be used to increase further our understanding of dise
