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1 In the present study, the inhibitory effects of the selective beta 2-adrenoceptor agonists, salmeterol, formoterol and salbutamol, have been investigated on contractions of ferret trachea induced both by endogenous and exogenous acetylcholine. The aim of the study was to evaluate quantitative and/or qualitative differences in response which may indicate both pre-and post-junctional sites of acti
We consider possible schemes for the resonance-enhanced two-photon ionization (RETPI) of Ne and Ar atoms under the action of bichromatic radiation of intense resonance lines of HI, HeI, and HeII in a radiation-rich astrophysical plasma. The ionization rate is comparable to or exceeds the recombination rate in rarified astrophysical plasma, which leads to the accumulation of singly ionized ions wit
Popular Abstract in Swedish Bakgrund Hur gatunätet ser ut och planera's i städer påverkar förutom trafikarbetet även hur bilister kör. Körbeteendet i form av körmönster, d.v.'s. hastighet's- och accelerationsprofiler, påverkar i sin tur såväl bränsleförbrukning som avgasemissionsfaktorer. En betydande del av trafiken sker inom tätorter där såväl luftkvalitet som totala utsläpp är av betydelse. ÄvThe planning and design of street networks in cities influence driving behaviour and give rise to variations in driving patterns (i.e., speed and acceleration profiles) that affect exhaust emissions and fuel consumption. The primary objective of this study has been to use real-life driving patterns to investigate how the characteristics of street networks influence fuel consumption and vehicular e
Type 2 diabetes (T2D) is a serious condition of growing proportions. Developing via an increasing imbalance between insulin sensitivity in the peripheral tissues and insulin release from pancreatic beta-cells, it ultimately renders the individual incapable of regulating the blood glucose concentration, e.g. after a meal. The increased prevalence of T2D is associated with an increase in the prevale
Eutrophication of the Baltic Sea has potentially increased the frequency and magnitude of cyanobacteria blooms. Eutrophication leads to increased sedimentation of organic material, increasing the Extent of anoxic bottoms and subsequently increasing the internal phosphorus loading. In addition, the hypoxic water volume displays a negative relationship with the total dissolved inorganic nitrogen poo
A molecular understanding of volatile anesthetic mechanisms of action will require structural descriptions of anesthetic–protein complexes. Porcine odorant binding protein is a 157 residue member of the lipocalin family that features a large β-barrel internal cavity (515 ± 30 Å3) lined predominantly by aromatic and aliphatic residues. Halothane binding to the β-barrel cavity was determined using f
Aims: This cohort study on urban middle-aged men investigates the association between the use of analgesics and hypnotics, self-rated health (SRI-I) and disability pension. Methods: Five birth-year cohorts of middle-aged, urban, Swedish men were invited to a screening programme and were followed for approximately 11 years. Results: Out of all the subjects (n = 5798), 12.4% received a disability pe
Popular Abstract in Swedish Blodgruppsantigen finns på den röda blodkroppens cellyta och även på många andra celltyper. I denna avhandling har jag studerat gener och dess varianter (polymorfismer) som är ansvariga för uttrycket av tre blodgruppsantigener av kolhydratnatur, nämligen Pk, P och P1. Dessa utgör P- och GLOB-blodgruppssystemen och GLOB-kollektionen. Fem olika fenotyper förekommer då anThe clinically important carbohydrate P/GLOB blood group systems and collection give rise to both common (P1, P2) and rare (p, P1k, P2k) blood group phenotypes. The associated antibodies are implicated in severe transfusion reactions and recurrent spontaneous abortions. The aim of this study was to explore the molecular genetic basis of Pk, P and P1 antigen expression. Sequence analysis of the A4
Repair and reconstruction of major nerve trunks in the upper extremity is a very challenging surgical problem. Today, there is no surgical repair technique that can assure recovery of tactile discrimination in the hand of an adult patient following nerve repair. In contrast, young individuals usually attain a complete recovery of functional sensibility. The outcome from nerve repair depends mainly
Multiple sclerosis (MS) is a chronic inflammatory disease of central nervous system (CNS) which is thought to arise from a breakdown of immunological tolerance in CD4 cells. The aim of this thesis is to improve our understanding of regulation mechanisms of T cell-dependent chronic inflammation in the CNS and explore ways to overcome the onset and progression of the disease, which can be an importa
Osteoarthritis (OA) and pigmented villonodular synovitis (PVNS) are disorders associated with trisomy 7. The aim of the present study was to determine the frequency and distribution of the cells with +7 in vivo by analyzing sections of paraffin-embedded synovia from patients affected by OA, PVNS, other forms of synovitis [hemorragic synovitis (HS) and chronic synovitis (CS)], and from individuals
Autoimmune diseases such as rheumatoid arthritis (RA) are chronic diseases that cannot be prevented or cured. If the pathologic basis of such diseases would be known, it might be easier to develop new drugs interfering with critical pathways. Genetic analysis of animal models for autoimmune diseases can result in discovery of proteins and pathways that play a key function in pathogenesis, which ma
OBJECTIVE: The underlying mechanisms of the differences in sex distribution of patients with atrioventricular (AV) nodal re-entrant tachycardia and Wolff-Parkinson-White syndrome are poorly understood. The objective of this study was to determine potential gender differences in the electrophysiological properties of the normal AV conduction system that may be attributable to differences in sex dis
Popular Abstract in Swedish Det är välkänt att övervikt och fetma är starkt associerade med sjukliga förändringar i hjärtkärlsystemet och ökar risken att drabbas av hjärtkärlsjukdom och förtida död. Trots att viktnedgång hos överviktiga kan leda till en tillbakagång av sjukliga förändringar i hjärta och kärl, har man dock inte klart visat att viktnedgång leder till minskad risk att drabbas av hjärHigh body mass index (BMI) is associated with cardiovascular risk factors such as hypertension, dyslipidemia, and insulin resistance. Obesity is also an independent risk factor for coronary artery disease (CAD) and can cause structural as well as functional changes in the heart. High BMI is associated with increased mortality in the population. Weight-loss from a state of overweight or obesity may
Many studies have supported a genetic etiology for autism. Here we report mutations in two X-linked genes encoding neuroligins NLGN3 and NLGN4 in siblings with autism-spectrum disorders. These mutations affect cell-adhesion molecules localized at the synapse and suggest that a defect of synaptogenesis may predispose to autism.
Breast carcinoma is thought to arise because of multiple successive changes in the genome of the normal epithelial cells. However, little is known of the order of appearance of different types of genetic aberrations We studied the ERBB2 (Her-2/neu) and CCND1 (cyclin D1) oncogene amplification in flow cytometrically sorted diploid and nondiploid tumor cell populations by fluorescence in situ hybrid
