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Genetic variation at the MTIF3 (Mitochondrial Translational Initiation Factor 3) locus has been robustly associated with obesity in humans, but the functional basis behind this association is not known. Here, we applied luciferase reporter assay to map potential functional variants in the haplotype block tagged by rs1885988 and used CRISPR-Cas9 to edit the potential functional variants to confirm
Mycosis fungoides (MF) and Sézary syndrome (SS) are two closely related clinical variants of cutaneous T-cell lymphomas (CTCL). Previously demonstrated large patient-to-patient and intra-patient disease heterogeneity underpins the importance of personalized medicine in CTCL. Advanced stages of CTCL are characterized by dismal prognosis, and the early identification of patients who will progress re
BACKGROUND: Low birth weight (LBW), advanced glycation end-products (AGE), and ankle-brachial index (ABI) have all been independently associated with risk of cardiovascular disease. Evidence is lacking on the effect of LBW on adult AGE, a marker of glucose metabolism, and ABI, a marker of peripheral atherosclerosis. The objective was to study these associations in a population-based cohort.METHODS
Although the effects of captive offshoring on firm innovation have increasingly become a subject of study, the literature did so far not distinguish between the effects on introducing innovation as opposed to the effects their market diffusion. This distinction is important. By integrating insights from the innovation diffusion literature, we argue that the effects of captive offshoring on home ba
Forced-choice response format is often considered superior to standard Likert format for controlling social desirability in personality inventories. We performed simulations and found that the trait information based on the two formats converges when the number of items is high and forced-choice items are mixed with regard to positively and negatively keyed items. Given that forced-choice items ex
This study presents 62 years of hindcast wave climate data for the south coast of Sweden from 1959–2021. The 100-km-long coast consists mainly of sandy beaches and eroding bluffs interrupted by headlands and harbours alongshore, making it sensitive to variations in incoming wave direction. A SWAN wave model of the Baltic Sea, extending from the North Sea to the Åland Sea, was calibrated and valida
Diffusion NMR and MRI methods building on the classic pulsed gradient spin-echo sequence are sensitive to many aspects of translational motion, including time and frequency dependence ("restriction"), anisotropy, and flow, leading to ambiguities when interpreting experimental data from complex heterogeneous materials such as living biological tissues. While the oscillating gradient technique speci
The climate crisis calls for a new generation of social policy compatible with planetary limits and economic postgrowth circumstances. This article analyses how some of the pillars of such a new generation of social policy may be conceptualized by highlighting commonalities between the most recent IPCC report and the sustainable welfare literature. Methodologically triangulating content analysis o
Förebyggande av oönskade graviditeter och sexuellt överförbara infektioner (vad jag kallar "contracepting") behandlas ofta som ett medicinskt eller hälsovårds- problem snarare än en social fråga. Till följd av detta, förblir mycket av det vardagliga arbetet som preventivmetoder innefattar osynligt. Unga människor i synnerlighet talas oftare om än med när det kommer till deras användning av preventContraception is a complex phenomenon with differing meanings, expressions, and materialities depending on its historical, social, and cultural context. In this thesis, I depart from the conceptualisation of contraception as the prevention of both pregnancies and sexually transmitted infections (STIs) and I name these practices through the collective term of contracepting. Previous research on you
Superdeformed and highly deformed rotational bands in the [Formula Presented] mass region are studied within cranked relativistic mean field theory and the configuration-dependent cranked Nilsson-Strutinsky approach. Both approaches describe the experimental data well. Low values of the dynamic moments of inertia [Formula Presented] compared with the kinematic moments of inertia [Formula Presented
The modified version of Bayesian Information Criterion (mBIC) is a relatively simple model selection procedure that can be used when locating multiple interacting quantitative trait loci (QTL). Our earlier work demonstrated the statistical properties of mBIC for situations where the average genetic map interval is at least 5 cM. In this work mBIC is adapted to genome searches based on a dense map
We study experimentally and with wave optics modelling the absorption of light in CsPbBr3perovskite nanowire arrays fabricated into periodic pores of an anodized aluminum oxide matrix, for nanowire diameters from 30 to 360 nm. First, we find that all the light that couples into the array can be absorbed by the nanowires at sufficient nanowire length. This behavior is in strong contrast to the expe
The experience of heritage sites through digital technology is an increasingly important topic for researchers and practitioners. Drawing upon telepresence theory, this study explores how a visitor’s destination image is formed and its impact on satisfaction in a virtual heritage site experience. The survey results show that telepresence, cognitive image, affective image, and satisfaction are posi
Both plasma tau phosphorylated at threonine-181 (pTau181) and tau PET show potential for detecting Alzheimer’s disease (AD) pathology and predicting clinical progression. In this study, we performed a head-to-head comparison between plasma pTau181 and tau PET along the AD continuum. Methods: We included participants from the Amsterdam Dementia Cohort who underwent 18F-flortaucipir (tau) PET and ha
BackgroundDiabetes and prediabetes are well-recognized risk factors for cardiovascular disease (CVD) and are marked by vascular endothelial dysfunction (ED). However, there is a scarcity of thorough population-based studies examining ED in individuals with diabetes/prediabetes free from manifest CVD. Here, we examined the association between ED assessed by reactive hyperaemia index (RHI) in the fi
Observational studies have revealed that ischemic heart disease (IHD) has a unique manifestation on electrocardiographic (ECG). However, the genetic relationships between IHD and ECG remain unclear. We took 12-lead ECG as phenotypes to conduct genome-wide association studies (GWAS) for 41,960 samples from UK-Biobank (UKB). By leveraging large-scale GWAS summary of ECG and IHD (downloaded from Finn
