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Inflammatory mediators are important in traumatic brain injury (TBI). The objective of the present study was to investigate the expression of cyclooxygenase-2 (COX-2), prostaglandin E (PGE) and PGD synthases, and PGH2 metabolism in two rat models of TBI. Fluid percussion injury (FPI) resulted in bilateral induction of COX-2 mRNA in the dentate gyri and the cortex, whereas controlled cortical contu
This article examines the links between post-conflict states’ troop contributions to international peacekeeping missions and security sector reform (SSR). It shows how SSR and troop-contribution preparations are increasingly interwoven and at times perceived as complementary by both external and internal actors. Some of the objectives sought after in SSR, such as the modernization of the military
Worldwide, information and communication technologies (ICT), particularly in the sense of digital literacy, are increasingly considered as both inevitable and indispensable parts of the school curriculum. Also, international student assessment studies like PISA have on several occasions assessed computer and information literacy. Additionally, classrooms, teaching and learning, as well as school a
The spectrum of Ti XFV has been observed in the wavelength region 80-550 Å using the fast ion beam spectroscopy method. 47 lines have been identified as transitions between the 2p4 3s, 3p, and 3d configurations in the 360-540 Å interval. The level identifications are supported by comparisons between observations and Hartree-Fock calculations along the F I isoelectronic sequence.
BACKGROUND: It has been proposed that interactions between selenium and arsenic in the body may affect their kinetics and toxicity. However, it is unknown how the elements influence each other in humans. OBJECTIVES: We aimed to investigate potential interactions in the methylation of selenium and arsenic. METHODS: Urinary selenium (U-Se) and arsenic (U-As) were measured using inductively coupled p
In terms of genome size, the hepatitis B virus is the smallest virus known to infect humans and its compactness with multiple overlapping reading frames puts restraints on the emergence of mutations. In the papers included in this thesis we aimed to investigate genetic variation within the precore and core promoter region and to describe the origin, spread and diversification of HBV genotype A. We
We present the generalized signal detection theory (GSDT), where familiarity is described by a sparse binomial distribution of binary node activity rather than by normal distribution of familiarity. Items are presented in a distributed representation, where each node receives either noise only, or signal and noise. An old response (i.e., a ‘yes’ response) is made if at least one node receives sign
Chloride ions play an important role in controlling excitability of principal neurons in the central nervous system. When neurotransmitter GABA is released from inhibitory interneurons, activated GABA type A (GABAA) receptors on principal neurons become permeable to chloride. Typically, chloride flows through activated GABAA receptors into the neurons causing hyperpolarization or shunting inhibiti
Providing health and social care to older persons is challenging, since older persons often have multiple diseases and a complex health situation. Hence many professions and organisations are involved. Lack of interprofessional and interorganisational collaboration leads to fragmented care. Care planning meetings before hospital discharge have long been used to overcome this fragmentation, but mee
This paper investigates the moisture dependency of ion diffusion in binary cementitious binders with Portland cement (OPC) in combination with slag or silica fume. Resistivity measurements and calculations with a thermodynamic model, GEMS, were used to assess the unsaturated chloride diffusion coefficient. The results show that the relation between the relative diffusion coefficient and the degree
During fetal development, mammalian back-skin undergoes a natural transition in response to injury, from scarless regeneration to skin scarring. Here, we characterize dermal morphogenesis and follow two distinct embryonic fibroblast lineages, based on their history of expression of the engrailed 1 gene. We use single-cell fate-mapping, live three dimensional confocal imaging and in silico analysis
Sauna sessions and winter swimming are traditional and popular recreational activities in certain countries. Their positive effects on health and relaxation, both as separate and combined activities, are commonly reported. However, systematic studies of these effects are relatively scarce, especially regarding the nonlinear analysis of the physiological measurements of the heart activity. We perfo
Objective Factors predicting survival over time after pediatric intensive care unit (PICU) admissions are not fully understood. The primary aim of the current study was to investigate whether multiple admissions (MADM) compared to single PICU admissions (SADM) were associated with poor survival over time after being admitted to PICU facilities. Our secondary aim was to investigate if the presence
Although predation is commonly thought to exert the strongest selective pressure on coloration in aposematic species, sexual selection may also influence coloration. Specifically, polymorphism in aposematic species cannot be explained by natural selection alone. Males of the aposematic wood tiger moth (Arctia plantaginis) are polymorphic for hindwing coloration throughout most of their range. In S
The economic crisis of 2008/2009 has increased unemployment among managers, particularly older managers, a group under-researched empirically. This longitudinal study assesses the efficacy of executive coaching for a group of unemployed professionals who participated in an intensive coaching programme aimed at reintegrating them into the economy. Results suggest that the majority were positive abo
Introduction: In healthy carriers of the T allele of the transcription factor 7-like 2 (TCF7L2), fasting plasma glucagon concentrations are lower compared with those with the C allele. We hypothesised that presence of the T allele is associated with a diminished glucagon response during hypoglycaemia and a higher frequency of severe hypoglycaemia (SH) in type 1 diabetes (T1DM). Material and method
This book is concerned with how search, searching and with them search engines have become so widely used that we have stopped noticing them. One of society’s key infrastructure for knowing and getting informed are computerised systems supporting the search for and locating of documents and information. The use of these systems, search engines, is curiously dispersed and centralised at the same ti
