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This article investigates by means of US Patent and Trademark Office (USPTO) patent data whether technological relatedness at the city level was a crucial driving force behind technological change in 366 US cities from 1981 to 2010. Based on a three-way fixed-effects model, we find that the entry probability of a new technology in a city increases by 30% if the level of relatedness with existing t
Popular Abstract in Swedish Dercums sjukdom är ovanlig sjukdom som kännetecknas av uttalad kronisk smärta (>3 månader) i fettväven, kombinerad med övervikt och ett antal mer diffusa associerade symptom, såsom trötthet och allmän sjukdomskänsla. Orsaken till sjukdomen är okänd. Smärtorna är ofta handikappande och de flesta prövade behandlingar, såsom traditionella smärtstillande, ger otillräcklig eDercum’s disease is a rare condition characterised by obesity, chronic pain (>3 months) in the adipose tissue and a number of diffuse associated symptoms, such as fatigue and malaise. The aetiology of the disease is unknown. The experienced pains are often disabling and resistant to most tried treatments, such as analgesics. However, a number of case reports have been published on the promising ef
Objective: Occupational workload has been associated with an increased risk of osteoarthritis. The objective was to further examine the association between workload and occurrence of osteoarthritis and in particular to study whether heavy workload has similar importance as a causative factor for osteoarthritis of the hip and knee. Methods: In a cohort study, the authors investigated the incidence
We report conductance and supercurrent of InAs nano wires coupled to Al-superconducting electrodes with short channel lengths and good Ohmic contacts. The nanowires are suspended 15 nm above a local gate electrode. The charge density in the nanowires can be controlled by a small change in the gate voltage. For large negative gate voltages, the number of conducting channels is reduced gradually, an
The fungal symbionts forming ectomycorrhizas, as well as their associated bacteria, benefit forest trees in a number of ways although the most important is enhancing soil nutrient mobilization and uptake. This is reciprocated by the allocation of carbohydrates by the tree to the fungus through the root interface, making the relationship a mutualistic association. Many field observations suggest th
PURPOSE. To describe and classify the morphologic changes in a naturally occurring dog model of early-onset cone-rod dystrophy (CRD) and to correlate these with earlier described clinical characteristics of the disease in dogs. METHODS. Purpose-bred Standard Wire-Haired Dachshunds (SWHDs) derived from a large pedigree of dogs with earlyonset CRD were euthanatized at defined ages to characterize mo
Cubozoan medusae have a stereotypic set of 24 eyes, some of which are structurally similar to vertebrate and cephalopod eyes. Across the approximately 25 described species, this set of eyes varies surprisingly little, suggesting that they are involved in an equally stereotypic set of visual tasks. During the day Tripedalia cystophora is found at the edge of mangrove lagoons where it accumulates cl
beta-Microseminoprotein (MSP), a 10kDa seminal plasma protein, forms a tight complex with cysteine-rich secretory protein 3 (CRISP-3) from granulocytes. The 3D structure of human MSP has been determined but there is as yet no 3D structure for CRISP-3. We have now studied the complex between human MSP and CRISP-3 with multidimensional NMR. (15)N-HSQC spectra show substantial differences between fre
This article describes the systematic design of a control structure for a biological wastewater treatment process as given by the test-bed Benchmark Simulation Model No. 1 (BSM1) and Activated Sludge Model No. 1 (ASM1). The objective of this work was to formalize and implement a systematic and yet simple procedure for the selection of control structures in wastewater treatment plants (WWTPs) and t
Assessment of the potential impact of climate change on water systems has been an essential part of hydrological research over the last couple of decades. However, the notion that such assessments should also include other changes is relatively recent. In this study, the potential impacts of climate change and continued urbanisation on stormwater flows to a suburban stream, Helsingborg, south Swed
The general concern for the state of the environment sets requirements on strategies developed by companies to curb environmental and social impacts of their activities. One of the most notable changes in the way companies work with sustainability issues is the shift of the focus from own operations to improving the performance of supply chains. This paper aims to analyse the practise of corporate
Low carbon sustainability has been addressed in China’s national development strategies. This research explores individual behaviour change and engagement in building low carbon communities in China through a case study looking at the building of a low carbon campus at Fudan University, Shanghai. Individual behaviour directly influences the overall energy consumption and carbon emissions on Fudan
The phosphatase and actin regulator 1 (PHACTR1) locus is a very commonly identified hit in genome-wide association studies investigating coronary artery disease and myocardial infarction (MI). However, the function of PHACTR1 in the heart is still unknown. We characterized the mechanisms regulating Phactr1 expression in the heart, used adenoviral gene delivery to investigate the effects of Phactr1
In this Letter, we use a discrete polarizable solvation model for a systematic analysis of the solvent effects on the nitrogen NMR shielding and nuclear quadrupole coupling constants in a series of 1-methyltriazoles. Fairly accurate predictions are found for the solvent shifts of the nitrogen NMR shielding constants. The analysis of the relative half-height widths of the resonance signal predicted
Osteoporosis is characterized by decreased bone mineral density (BMD) leading to reduced bone strength and increased fracture risk. Several heritable components affect a bone’s ability to resist fracture, including size, structure and strength; therefore identification of the genes underlying several bone characteristics will help elucidate the pathogenesis of fracture risk. Dissection of the gene
The ATLAS (A Toroidal LHC ApparatuS) Inner Detector provides charged particle tracking in the centre of the ATLAS experiment at the Large Hadron Collider (LHC). The Inner Detector consists of three subdetectors: the Pixel Detector, the Semiconductor Tracker (SCT), and the Transition Radiation Tracker (TRT). This paper summarizes the tests that were carried out at the final stage of SCT+TRT integra
Background: Models based on using perturbative polarization corrections and mean-field blocking approximation give conflicting results for masses of odd nuclei. Purpose: We systematically investigate the polarization and mean-field models, implemented within self-consistent approaches that use identical interactions and model spaces, to find reasons for the conflicts between them. Methods: For den
Organisms usually benefit from heterogeneous conditions, but, by doing so, may reduce the degree of heterogeneity. The question therefore arises how heterogeneity is maintained. We investigated within-year spatiotemporal patterns in a monospecific stand of a submerged plant (fennel pondweed, Potamogeton pectinatus), with the novelty that we distinguished between different forms of heterogeneity: s
