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Researchers often aim to make correct inferences both about that which is actually studied (internal validity) and about what the results generalize to (external validity). The language of internal and external validity is not used by everyone, but many of us would agree that intuitively the distinction makes a lot of sense. Two claims are commonly made with respect to internal and external validi

This paper explores the concept of organizations as complex human activity systems, through the perspectives of alternative systemic models. The impact of alternative models on perception of individual and organizational emergence is highlighted. Using information systems development as an example of management activity, individual and collective sense-making and learning processes are discussed.

Popular Abstract in Swedish Den moderna epokens början återfinns i det sena sjuttonhundratalet och i Europa. Det är en epok, en kultur som förstår sig som både ny och som annorlunda i förhållande till tidigare epoker och kulturer, sådana som vilat på myter, religion och tradition. Den nya kulturens fundamentala insikt bestod i att ingenting måste vara så som det är, utan allt vore möjligt också påThe problem which the present study discusses is modernity. The study interprets modernity’s cultural and anthropological dispositions as historical appearances. Consequently, it is situated at the intersection of cultural sociology and historical anthropology. The aim is to generate insight and understanding rather than a coherent theory. The key element consists of combination and variation of c

All service control nodes, for example SCPs, HLRs, and MSCs, are constructed as a server system with one or more servers that process incoming requests. Since service control nodes are sensitive to overload, admission control mechanisms are often implemented. In this paper, we model and analyse admission control mechanisms for server systems with control theoretic methods. We develop a nonlinear s

Introduction: The spatial peaks QRS-T angle accurately distinguishes children with hypertrophic cardiomyopathy from their healthy counterparts. The spatial peaks QRS-T angle is also useful in risk stratification for ventricular arrhythmias. We hypothesised that the spatial peaks QRS-T angle would be useful for the prediction of ventricular arrhythmias in hypertrophic cardiomyopathy patients under

The molecular epidemiology of HIV-1 in Iceland has not been described so far. Detailed analyses of the dynamics of HIV-1 can give insights for prevention of virus spread. The objective of the current study was to characterize the genetic diversity and transmission dynamics of HIV-1 in Iceland. Partial HIV-1 pol (1020bp) sequences were generated from 230 Icelandic samples, representing 77% of all H

OBJECTIVE: Insulin-like growth factor 1 receptor (IGF1R) acts at the crossroad between immunity and cancer, being an attractive therapeutic target in these areas. IGF1R is broadly expressed by antigen-presenting cells (APC). Using mice immunised with the methylated albumin from bovine serum (BSA-immunised mice) and human CD14 + APCs, we investigated the role that IGF1R plays during adaptive immune

We report the discovery of a third planet transiting the star TOI-1260, previously known to host two transiting sub-Neptune planets with orbital periods of 3.127 and 7.493 d, respectively. The nature of the third transiting planet with a 16.6-d orbit is supported by ground-based follow-up observations, including time-series photometry, high-angular resolution images, spectroscopy, and archival ima

Background: In Western settings, community-acquired pneumonia (CAP) due to Gram-negative bacilli (GNB) is relatively rare. Previous studies from Asia, however, indicate a higher prevalence of GNB in CAP, but data, particularly from Southeast Asia, are limited. Methods: This is a prospective observational study of 1451 patients ≥15 y of age with CAP from two hospitals in Cambodia between 2007 and 2

The effect of surface strain on the passive film evolution of SAF 2507 super duplex stainless steel exposed to ambient air and 0.1 M NaCl solution with varying anodic polarization at room temperature has been investigated using in-situ grazing incidence X-ray diffraction (GIXRD) in combination with electrochemical measurements. Surface strain affected the crystallinity of the passive film as such

The human bone marrow (BM) gives rise to all distinct blood cell lineages, including CD1c+ (cDC2) and CD141+ (cDC1) myeloid dendritic cells (DC) and monocytes. These cell subsets are also present in peripheral blood (PB) and lymphoid tissues. However, the difference between the BM and PB compartment in terms of differentiation state and immunological role of DC is not yet known. The BM may represe

The main objective of this paper is to design a common background for various philosophical discussions about adequate conceptual analysis of “computation”.

Energy use in buildings has a significant influence on the global energy demand and environmental impacts. Among all building systems, heating, ventilation, and air conditioning (HVAC) systems are the most energy-intensive in terms of their total energy requirements. The production and operation of HVAC systems have a significant impact on the environment. These systems are also among the largest

Cost of flight at various speeds is a crucial determinant of flight behaviour in birds. Aerodynamic models, predicting that mechanical power (Pmech) varies with flight speed in a U-shaped manner, have been used together with an energy conversion factor (efficiency) to estimate metabolic power (Pmet). Despite few empirical studies, efficiency has been assumed constant across flight speeds at 23%. I

YKL-40, also called human cartilage glycoprotein-39 (HC gp-39), is a member of family 18 glycosyl hydrolases. YKL-40 is secreted by chondrocytes, synovial cells, and macrophages, and recently it has been reported that YKL-40 has a role as an autoantigen in rheumatoid arthritis (RA). The function of YKL-40 is unknown, but the pattern of its expression in normal and disease states suggests that it c

Objective: Neurological outcome prediction is crucial early after cardiac arrest. Serum biomarkers released from brain cells after hypoxic-ischaemic injury may aid in outcome prediction. The only serum biomarker presently recommended in the European Resuscitation Council prognostication guidelines is neuron-specific enolase (NSE), but NSE has limitations. In this study, we therefore analyzed the o

Popular Abstract in Swedish Sedan 1981, då de första fallen av AIDS beskrevs, har 25 miljoner människor dött på grund av att de har blivit smittade av immunbristviruset HIV . Det finns idag mer än 40 miljoner människor som lever med HIV eller AIDS. SIV är apsläktets variant på HIV och orsakar normalt ingen sjukdom hos sina värddjur som är olika afrikanska apor, men då asiatiska apor, t. ex. makakeSimian immunodeficiency virus (SIV) infections in macaques are commonly used as models to study the pathogenesis of human immunodeficiency virus (HIV). Both SIV and HIV normally use the CD4 receptor and an additional coreceptor for cell entry. The most common coreceptors used by HIV are CCR5 and CXCR4. SIV use CCR5 and rarely CXCR4 but may use other coreceptors as alternatives. We have studied vi