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Background: Mohs micrographic surgery (MMS) is a precise, tissue-sparing surgical technique that offers superior cure rates compared to traditional surgical excision. However, the degree of difficulty of MMS depends on many variables, and consequently, the number of surgical stages required for each case is quite unpredictable.Objectives: To identify risk factors for complicated MMS, defined as MM
A frequency domain, weighted least squares, sensitivity function shaping procedure is presented. Pole placement is used as the basic servo design procedure. Controller overparametrization gives the degree of freedom for shaping the sensitivity function. A benchmark design example shows the capabilities of the method. The computation is simple making the design suitable for adaptive control.
CONTEXT: Vitamin D (Vit-D), parathyroid hormone (PTH), and fibroblast growth factor 23 (FGF23) are the major calciotropic hormones involved in the regulation of blood calcium levels from the intestine, kidney, and bone through a tight endocrine feedback loop system. Altered levels of calcium itself or through the effect of its regulatory hormones could affect blood pressure (BP), but the exact mec
Mesenchymal stromal cells (MSCs) were identified more than 50 years ago, and research advances have promoted the translation of pre-clinical studies into clinical settings in several diseases. However, we are only starting to uncover the local factors that regulate cell phenotype, cell function, and cell viability across tissues following administration in different diseases. Advances in pre-clini
BACKGROUND: KRAS mutation can alter the treatment plan after resection of colorectal cancer. Despite its importance, the KRAS status of several patients remains unchecked because of the high cost and limited resources. This study developed a deep neural network (DNN) to predict the KRAS genotype using hematoxylin and eosin (H&E)-stained histopathological images. STUDY DESIGN: Three DNNs were c
Eight frequently used slope algorithms based on a DEM (Digital Elevation Model) have been compared in flat, gently sloping/undulating, and steep terrain in order to investigate differences in estimated results. The matter of scale/resolution has not been considered, and the focus has not been on comparing the estimates with "ground truth" data but on comparisons between the different algorithms. P
COVID-19 is characterized by a dysregulated and excessive inflammatory response and, in severe cases, acute respiratory distress syndrome. We have recently demonstrated a previously unknown high-affinity interaction between the SARS-CoV-2 spike (S) protein and bacterial lipopolysaccharide (LPS), leading to the boosting of inflammation. Here we present a mouse inflammation model employing the coadm
This chapter examines how three parties of the radical right reinterpret the Nordic welfare model to serve a nativist purpose. These parties are the Danish People’s Party (Dansk Folkeparti, DF), the Finns Party (Perussuomalaiset/Sannfinländarna, PS), and the Sweden Democrats (Sverigedemokraterna, SD). The period under analysis stretches from 2009 to 2019, which saw the electoral consolidation of t
BACKGROUND: Cell blocks (CBs) are widely used for biomarker analyses such as immunostaining. Although immunohistochemistry on formalin-fixed paraffin-embedded tissues is standardized, there are multiple preparation methods and fixatives for cytology. Our objective was to investigate the effect of different common fixatives on the immunoreactivity of pleural effusion CBs with metastatic lung adenoc
Audio description (AD) plays a crucial role in making audiovisual media accessible to people with a visual impairment, enhancing their experience and understanding. This study employs an event segmentation task to examine how people without sight perceive and segment narrative events in films with AD, compared to sighted viewers without AD. Two AD versions were utilized, differing in the explicitn
The core aim of this chapter is to explore the potential of the EU Charter in developing social protection in times of poly-crisis. In the past, EU Member States have gone through a number of events that have been termed as crises, calling for a paradigm shift in EU governance (economic, migration, and more recently health crises). While the effects of these crises are still felt, the EU is faced
Background: Involving librarians as team members can lead to better quality in reviews. To improve their search results, an international diabetes project involved two medical librarians in a large-scale project planning of a series of systematic reviews for clinical guidelines in diabetes precision medicine. Case Presentation: The precision diabetes project was divided into teams. Four diabetes m
Purpose: The number of women living with breast cancer (BC) is increasing, and the efficacy of surveillance programs after BC treatment is essential. Identification of links between mammographic features and recurrence could help design follow up strategies, which may lead to earlier detection of recurrence. The aim of this study was to analyze associations between mammographic features at diagnos
CONTEXT: A healthy lifestyle is the cornerstone of management in nonalcoholic fatty liver disease (NAFLD). However, the associations between dietary macronutrient composition and different aspects of NAFLD pathology are unclear and dietary recommendations for NAFLD are lacking.OBJECTIVE: This work aimed to evaluate the associations of dietary macronutrient composition with hepatic steatosis, hepat
In the present paper we consider the problem of attitude synchronization for a system of rigid body agents. We provide distributed kinematic control laws for two different synchronization problems. In the two problems the objective is the same, i.e., to synchronize the orientations of the agents, but what is assumed to be measurable by the agents differs. In problem 1 the agents measure their own
A group of pre-service teachers were studied from two social practices, as teachers and as students. Their perceptions of mathematics concepts and beliefs about the mathematics teacher role were studied through questionnaires, interviews and classroom observations. Three students were selected as cases in this paper where their links between the concepts limits, derivatives, integrals and continui
This study is a follow-up investigation of the influence of the alloying elements Nd and La on the corrosionCorrosionby immersionImmersion of an extruded and heat-treated Mg10Gd. The previous study made clear that the age-hardened condition has the lowest corrosion rateCorrosion Rate but high pitting corrosionPitting corrosion susceptibility. The extruded Mg10Gd(1Nd)1La shows the lowest pitting fa
