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The prevalence of chronic fundus diseases is increasing with the aging of the general population. The treatment of these intraocular diseases relies on invasive drug delivery because of the globular structure and multiple barriers of the eye. Frequent intraocular injections bring heavy burdens to the medical care system and patients. The use of topical drugs to treat retinal diseases has always be

In this chapter I analyse the recent criminalization of negligent rape in Sweden, introduced in 2018. My aim is to contribute to the discussion of criminalization as it relates to violence against women, while taking a broad view of criminalization that includes not only criminalization per se but also the application of law. My analysis of the application of the crime of negligent rape, from the

Factor V Leiden and factor II G20210A mutations are two frequent genetic risk factors involved in venous thromboembolism (VTE). The goal of this pooled analysis of 8 case-control studies, comprising a total of 2310 cases and 3204 controls, was to precisely estimate the risk of VTE in patients bearing both mutations (double heterozygotes). Odds ratios for VTE were 4.9 (95% CI; 4.1-5.9) for the fact

Purpose Competence is a prerequisite to achieve a well-functioning and competitive supply chain (SC). The purpose of this review is to present an integrated view of the published literature on all the aspects and facets of supply chain competence, and to present a framework for classification and analysis to facilitate further study, practice and research. Design/methodology/approach A structured

This paper provides a theoretical synthesis of three research areas – gender, nationalism and citizenship – by linking together the gendered discourses of ethno-nationalism and citizenship. It explores the potential for building a gender equal citizenship in societies divided by ethno-national conflict. More specifically, it analyzes women’s activism and participation in public and political life

Conventional cemented carbide is recommended for machining Ti6Al4V. However, polycrystalline diamond (PCD) and polycrystalline cubic boron nitride (pcBN) also show promise. Demands for higher productivity accelerate diffusional dissolution and chemically driven wear mechanisms in these tool materials. This study investigates active wear mechanisms by studying the interactions between Ti6Al4V and P

The Brazilian National Synchrotron Light Laboratory, LNLS, operates a synchrotron light source consisting of a 1.37 GeV electron storage ring and a 120 MeV injector. A summary of the commissioning and operation performance of the vacuum system for the linear accelerator (LINAC), transport line, RF system and storage ring is presented. The performance of the subsystems is described including the ph

Global climate change is one of the greatest environmental threats facing humanity and it is affecting every country on every continent. Recent evidence confirms a close liaison between climate change induced hazards and the built environment, as the built environment demonstrates a high fragility and vulnerability to hazardous situations. The impact of climate change is particularly pertinent to

The COVID-19 pandemic was a novel biological hazard that emerged in 2019 and significantly impacted various sectors of society. While sectors such as the economy and health were severely affected, the education sector was no stranger to the grave impact of the pandemic. While the pandemic called for regulations such as lockdowns and social distancing, the education sector was required to shift the

We present a newly funded research program, DESCRYPT, aimed at deciphering and analyzing historical texts with rare or unknown scripts. The project leverages advancements in computational linguistics, artificial intelligence (AI), and image processing, alongside traditional philological methods, to develop innovative tools for transcription, recognition, and interpretation of historical writings w

Aims: Superficial CD34-positive fibroblastic tumour (SCD34FT) is an uncommon but distinctive low-grade neoplasm of the skin and subcutis that shows frequent CADM3 expression by immunohistochemistry (IHC). In this study, prompted by an index case resembling ‘atypical fibrous histiocytoma (FH)’ that was positive for CADM3 IHC, we systematically examined a cohort of tumours previously diagnosed as ‘a

OBJECTIVE: There is growing interest in how peers' genotypes may influence health (i.e., peer social genetic effects). The authors sought to clarify the nature of peer social genetic effects on risk for drug use disorder, alcohol use disorder (AUD), major depression, and anxiety disorder. METHOD: Cox models were used with data from a population-based Swedish cohort (N=655,327). Outcomes were drug

Repair and replacement strategies using cell replacement or viral gene transfer for neurologic diseases are becoming increasingly efficacious with clinically meaningful benefits in several conditions. An increased understanding of disease processes opens up opportunities for genetic therapies and precision medicine methods aiming at disease modification or repair of lesioned neurologic structures.

Background: The affective profiles model has been used in several studies investigating individual differences in, for example, well-being and ill-being. The model categorizes individuals in four profiles based on the balance of high/low positive/negative affect: (1) self-fulfilling (high positive affect, low negative affect); (2) high affective (high positive affect, high negative affect); (3) lo

In vehicular communications systems the channel estimation filter suppresses the additive noise in channel estimates obtained from pilot symbols. Vehicular channels show local stationarity for a finite region in time and frequency, only. Such a process can be divided into consecutive stationarity regions, allowing to calculate a Wiener filter. We analyze the increase of the mean square error (MSE)

Non-responders to checkpoint inhibitors generally have low tumor T cell infiltration and could benefit from immunotherapy that activates dendritic cells, with priming of tumor-reactive T cells as a result. Such therapies may be augmented by providing tumor antigen in the form of cancer vaccines. Our aim was to study the effects of mitazalimab (ADC-1013; JNJ-64457107), a human anti-CD40 agonist IgG

Although CD8+ T cell tolerance to tissue-specific antigen (TSA) is essential for host homeostasis, the mechanisms underlying peripheral cross-tolerance and whether they may differ between tissue sites remain to be fully elucidated. Here, we demonstrate that peripheral cross-tolerance to intestinal epithelial cell (IEC)–derived antigen involves the generation and suppressive function of FoxP3+CD8+

I discuss the dilution of responsibility of action and the idea of a symmetrical relationship between artefacts and humans. In doing so, I argue that meaning making is an activity unilaterally performed by agents, leading to an asymmetrical relationship between agents and artefacts. Therefore, the study of the one who is responsible for the action, the meaning-maker (with the capability to act) is