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SOX9 is a transcription factor of the SRY family that regulates sex determination, cartilage development and numerous other developmental events. In the foetal growth plate, Sox9 is highly expressed in chondrocytes of the proliferating and prehypertrophic zone but declines abruptly in the hypertrophic zone, suggesting that Sox9 downregulation in hypertrophic chondrocytes might be a necessary step

We analyze the convergence rate of the Dirichlet-Neumann iteration for the fully discretized unsteady transmission problem. Specifically, we consider the coupling of two linear heat equations on two identical non overlapping domains with jumps in the material coefficients across these. In this context, we derive the iteration matrix of the coupled problem. In the 1D case, the spectral radius of th

The most important goals for the field of immuno-oncology are to improve the response rate and increase the number of tumor indications that respond to immunotherapy, without increasing adverse side effects. One approach to achieve these goals is to use tumor-directed immunotherapy, i.e., to focus the immune activation to the most relevant part of the immune system. This may improve anti-tumor eff

Experimental and numerical investigations of the ignition of hydrogen/air mixtures by jets of hot exhaust gases are reported. An experimental realisation of such an ignition process, where a jet of hot exhaust gas impinges through a narrow nozzle into a quiescent hydrogen/air mixture, possibly initiating ignition and combustion, is studied. High-speed laser-induced fluorescence (LIF) image sequenc

This paper describes an 8-Bit, 100-MHz current steering CMOS low glitch interpolation digital to analog converter (DAC). It includes a 16-tap voltage controlled delay line and 8-Bit based linear interpolators, making the effective clock rate up to 1.6-GHz. With the linear interpolation, the requirement on the analog reconstruction filter is relaxed, and low glitch digital to analog conversion is a

The detection of the formyl radical (HCO) is of great interest in the field of combustion research since it can provide information about the local heat release (HR) rate which is a key parameter in the understanding of combustion processes. Unfortunately, due to the low signal level, HCO planar laser-induced fluorescence (PLTF) has so far not been applicable for single-shot imaging, which is nece

Viruses may be part of the pathogenesis of rheumatoid arthritis (RA). Double stranded RNA (dsRNA) is a prototypic viral conformation of nucleic acid that is highly arthritogenic in mice. Therefore, we developed an ELISA to detect dsRNA in sera and synovial fluids (SF) in RA patients and in osteoarthritic controls. The developed ELISA recognizes picogram levels of viral or synthetic dsRNA but shows

Radiative lifetime measurements were performed with time-resolved laser-induced fluorescence techniques for 24 levels of Nd II in the energy range 20 500- 32 500 cm(-1). For 17 levels, no previous experimental data exist. These results have allowed the testing of new theoretical calculations with the relativistic Hartree-Fock method taking configuration interactions and core-polarization effects i

We report laboratory measurements of oscillator strengths for 44 transitions in the Mn T spectrum covering the wavelength range 209-2780 nm. Nine energy level lifetimes have been measured using time resolved laser-induced fluorescence (LIF). The lifetimes have been combined with branching fractions measured by Fourier transform spectroscopy to obtain absolute oscillator strengths. In total, 24 of

With ultraviolet illumination, we have found a broad UV-induced absorption in the blue and some involvement of Pr ions in Pr:LiNbO 3 . Transient and stable absorption induced by UV illumination was analyzed at 457, 514, and 633 nm and could be explained by hole trap centers and iron ions. We also studied the effects of UV illumination and boundary conditions during holographic recording in the vi

Global warming and an increasing population needing more buildings are important issues ahead. Hence, Net ZEBs and green buildings is one of many necessary measures for climate change mitigation. Some studies indicate that improved energy and/or green performance in these buildings may not be profitable. However, a short time perspective and narrow concept for evaluation may be wrong. This study p

The role of the exocrine pancreas in regulating gut microflora colonization is unclear. The main objective in the present study was to assess the affect of pancreatic fluid on the growth of pathogenic bacteria and fungi. Pancreatic juice samples used in the study were obtained from nine eight-week old weaned pigs in which catheters were implanted in the pancreatic duct. The antibacterial activity