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Disability, Justice and Freedom as Non-Domination
Disability scholars have recently proposed that republican theory is relevant to think about justice in relation to disability. Following in their footsteps, this article submits that the republican conception of freedom as non-domination provides a fresh angle to legitimise disability rights in terms of justice and prevent their interpretation as charity or privileges. This proposition takes its
Danish stød as a cue to upcoming suffixes : An ERP and response time study
Multilevel Climate Governance in Brazil and Indonesia : Domestic Pioneership and Leadership in the Global South
Focusing on forest policy and urban climate politics in Brazil and Indonesia, the primary objective of this chapter is to identify domestic pioneers and leaders who, compared to other sectors, governmental levels or jurisdictions within the same nation-state, move ‘ahead of the troops’ (Liefferink and Wurzel, 2017: 2-3). The chapter focuses especially on the role of multilevel governance in bringi
Degrowth
This chapter is devoted to introducing degrowth to anyone interested in environmental politics and making connections between the two areas. It articulates critiques of growth, alternatives associated with degrowth and the politics of pursuing them. It is argued that economic growth, with GDP being its key indicator, comes with environmental degradation and is rooted in injustices. Degrowth schola
Introducing AI into urban studies
Innovation in artificial intelligence (AI) is transforming cities in unprecedented ways. In this chapter, we unpack the connections between AI and the urban by introducing the concept of urban AI and reflecting on its most prominent incarnations: autonomous vehicles, urban robots, city brains and urban software agents. We then illustrate how the emergence of urban AI is producing a new urbanism th
Cognitive Grammar
This entry offers a short description of the fundamental assumptions of grammar within the broad framework of Cognitive Linguistics. It presents the principles of usage-based cognitive grammar (CG), classic works in the framework, and more recent treatments of grammatical structure and content in the form of examples of grammatical notions. Central to the CG approach is the meaningful functioning
Plasma Alkylresorcinols is an objective biomarker for gluten intake in young children
BackgroundAlkylresorcinols are a well-established biomarker for whole grain intake. There is evidence suggesting that total plasma alkylresorcinol concentration may also be used as a biomarker for gluten intake in adults.ObjectiveThe aim of the study was to evaluate if total alkylresorcinol concentration is a valid biomarker for gluten intake in young children.MethodsNon-fasting plasma alkylresorc
Data Transparency and Pharmaceutical Regulation in Europe : Road to Damascus, or Room without a View?
Axon morphology is modulated by the local environment and impacts the noninvasive investigation of its structure-function relationship
Axonal conduction velocity, which ensures efficient function of the brain network, is related to axon diameter. Noninvasive, in vivo axon diameter estimates can be made with diffusion magnetic resonance imaging, but the technique requires three-dimensional (3D) validation. Here, high-resolution, 3D synchrotron X-ray nano-holotomography images of white matter samples from the corpus callosum of a m
Vorsprung durch Technik: The Future of Work, Digital Technology, and the Platform Economy
1H detection and dynamic nuclear polarization–enhanced NMR of Aβ1-42 fibrils
Several publications describing high-resolution structures of amyloid-β (Aβ) and other fibrils have demonstrated that magic-angle spinning (MAS) NMR spectroscopy is an ideal tool for studying amyloids at atomic resolution. Nonetheless, MAS NMR suffers from low sensitivity, requiring relatively large amounts of samples and extensive signal acquisition periods, which in turn limits the questions tha
Sex differences in vocal behavior in virtual rooms compared to real rooms
This study investigates speech production under various room acoustic conditions in virtual environments, by comparing vocal behavior and the subjective experience of speaking in four real rooms and their audio-visual virtual replicas. Sex differences were explored. Males and females (N = 13) adjusted their voice levels similarly to room acoustic changes in the real rooms, but only males did so in
Reply to : Opioids for dyspnoea in interstitial lung disease: does the sequence and timing of therapy matter?
Structural Variants in the SMC1A Gene Associated With Near-Haploidy in Undifferentiated Pleomorphic Sarcomas
Near-haploidization, that is, loss of one copy of most chromosomes, is a relatively rare phenomenon in most tumors, but is enriched among certain soft tissue sarcomas, including undifferentiated pleomorphic sarcoma (UPS). Presumably, near-haploidization can arise through many mechanisms. This study aimed to identify gene rearrangements that could cause near-haploidization. We here present two UPS
Lipid shape and packing are key for optimal design of pH-sensitive mRNA lipid nanoparticles
The ionizable-lipid component of RNA-containing nanoparticles controls the pH-dependent behavior necessary for an efficient delivery of the cargo - the so-called endosomal escape. However, it is still an empirical exercise to identify optimally performing lipids. Here, we study two well-known ionizable lipids, DLin-MC3-DMA and DLin-DMA using a combination of experiments, multiscale computer simula
ALK signaling primes the DNA damage response sensitizing ALK-driven neuroblastoma to therapeutic ATR inhibition
High-risk neuroblastoma (NB) is a significant clinical challenge. MYCN and Anaplastic Lymphoma Kinase (ALK), which are often involved in high-risk NB, lead to increased replication stress in cancer cells, suggesting therapeutic strategies. We previously identified an ATR (ataxia telangiectasia and Rad3-related)/ALK inhibitor (ATRi/ALKi) combination as such a strategy in two independent genetically
The perception of gonna and gotta – a study of emancipation in progress
This is an experiment the perceptual differences between full and contractedsemi-modals in English, i.e. the distinction of going to vs gonna and (HAVE) gotto vs gotta. It is a listen-and-repeat experiment and is informed by the findingsof a corpus study of the use of these forms in American English (AmE). It thusaims to integrate the social/variational and the cognitive sides of the phenomenon.
Evolution: lab-grown ‘mini brains’ suggest one mutation might have rewired the human mind
Introduction : It Is the Best of Times; It Is the Worst of Times
Our point of departure has been that, by using the language of solidarity, we - consciously or not - participate in the politics of it. The group of authors coming together in this volume contribute analyses of solidarity as a norm, a process, a practice, or a vocabulary creating polyperspectivity. In so doing, we let the course of our analysis be directed by the actors we investigate over a span
