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Immunomodulation - a disease-modifying avenue for treatment of Huntington's disease?

This Editorial highlights a study published in the current issue of Journal of Neurochemistry by Dobson et al. (), investigating whether the immunomodulatory agent, laquinimod exerts an immunomodulatory effect on isolated Huntington´s disease monocytes. In Huntington´s disease (HD) a central immune activation is mirrored in the periphery by a low-grade immune response and monocytes isolated from H

Proteoglycans of joint cartilage. Structure, function, turnover and role as markers of joint disease

Joint cartilage consists of cells embedded in a matrix of fibrous collagen within a concentrated water-proteoglycan gel. The integrity of this matrix is crucial for the biomechanical properties of the joint cartilage. The different components of the matrix are synthesized and degraded by the cartilage cells, a process regulated by the amount of mechanical stress applied to the chondrocytes as well

Greek collections of the Apophthegmata Patrum as found in Scorialensis R.II.1 and related manuscripts

The so called Collectio Scorialensis parva is an unedited alphabetical collection of stories about Egypti an desert fathers. It is found in two Greek MSS: Scorialensis R.II.1 and Parisinus gr. 919. They also contain a larger collection of the Apophthegmata Patrum, the so called alphabetica - anonyma derivata. Other manuscripts preserve this latter collection in a later stage, where all or parts of