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Chapter 1, Introduction

This book provides a number of studies of different aspects of Swedish child language. Some of the thematic chapters present original, unpublished data: on the acquisition of tense, on the range and frequency of different word order patterns in early child Swedish, related to the input, meaning the language of adults talking to the children or in the presence of the children. The remaining chapter

Comparing Nations - Perceptions of Global Risk and Environmental Concern

The intention of this chapter is neither a pure methodological nor a theoretical discussion, but instead, an empirical analysis which aims to understand variations in perceptions of global risks and environmental concern in a number of countries. The discussion, however, relies on methodological as well as theoretical perspectives concerning the shortcomings and pitfalls one encounters in comparin

Broken technologies : the humanist as engineer. Updated November 2015

There are many possible definitions of “technology” and I will discuss some of these in this book. However, in this introduction let me use a definition of Svante Lindqvist who defines technology very intuitively as “those activities, directed towards the satisfaction of human wants, which produce change in the material world.” He says also “the distinction between human “wants” and more limited h

Doing archaeology in popular culture

The popular image of archaeology and what archaeologists do is based on various clichés which emphasise, among other things, adventurous fieldwork, the discovery of treasures and historical detective work. Although archaeologists may see themselves differently, their image in popular culture reveals a lot about how the subject is perceived and why it is so widely appreciated at present. I suggest

Altered Sensory Experience Exacerbates Stable Dendritic Spine and Synapse Loss in a Mouse Model of Huntington's Disease.

A key question in Huntington's disease (HD) is what underlies the early cognitive deficits that precede the motor symptoms and the characteristic neuronal death observed in HD. The mechanisms underlying cognitive symptoms in HD remain unknown. Postmortem HD brain and animal model studies demonstrate pathologies in dendritic spines and abnormal synaptic plasticity before motor symptoms and neurodeg

Comprehensive analysis of microRNA expression in regionalized human neural progenitor cells reveals microRNA-10 as a caudalizing factor.

MicroRNAs (miRNAs) have been implicated in regulating multiple processes during brain development in various species. However, the function of miRNAs in human brain development remains largely unexplored. Here, we provide a comprehensive analysis of miRNA expression of regionalized neural progenitor cells derived from human embryonic stem cells and human foetal brain. We found miR-92b-3p and miR-1

Antibody array generation and use.

Affinity proteomics, represented by antibody arrays, is a multiplex technology for high-throughput protein expression profiling of crude proteomes in a highly specific, sensitive, and miniaturized manner. The antibodies are individually deposited in an ordered pattern, an array, onto a solid support. Next, the sample is added, and any specifically bound proteins are detected and quantified using m

TP53 Mutations are infrequent in newly diagnosed chronic lymphocytic leukemia

TP53 mutations in the absence of 17p-deletion correlate with rapid disease progression and poor survival in chronic lymphocytic leukemia (CLL). Herein, we determined the TP53 mutation frequency in 268 newly diagnosed CLL patients from a population-based material. Overall, we detected TP53 mutations in 3.7% of patients (n = 10), where 7/10 cases showed a concomitant 17p-deletion, confirming the hig

The Integrity of the Clean Development Mechanism - an interdisciplinary study on delegation

The Clean Development Mechanism (CDM) is a mechanism under the Kyoto Protocol, which allows industrialised countries that have binding emission targets to invest in emission reduction projects in non-industrialised countries. These CDM investments generate certified emission reductions (CERs), which can be used by the industrialised countries towards meeting their own targets. The dual objective o