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Pentadecamer-binding proteins : Definition of two independent protein-binding sites needed for functional activity

The SP6 κ-promoter pentadecamer (pd) element was found to be unable to stimulate transcription when present in one copy as the only promoter element in a minimal promoter but showed weak stimulatory activity when present as a multimer (four copies). One copy of the pd element acted synergistically with an octamer element, but not with a SP1 site, to stimulate transcription. The effect was orientat

Train-induced vibrations in cross-laminated timber buildings : A parametric study

This study explores structural modifications for reducing train-induced vibrations in timber buildings by modifying the building layout. A parameter study was conducted using a semi-analytical ground model coupled with a finite element structural model. The train load was modeled as a stationary oscillating point load of unit magnitude, applied on the ground surface. The analyzed frequency range,

Sanctions at Sea: A Study of the Russian Shadow Fleet’s Exploitation of Legal Gaps in International Maritime Law

Som en reaktion på Rysslands fullskaliga invasion av Ukraina har EU och allierade G7-länder infört omfattande sanktioner riktade mot rysk olja och petroleumprodukter. För att kringgå dessa sanktioner har Ryssland i allt större utsträckning förlitat sig på en parallell flotta – en så kallad skuggflotta – som har kommit att spela en betydande roll i finansieringen av den ryska krigföringen. SkuggfloIn response to Russia’s full-scale invasion of Ukraine, EU and allied G7 countries implemented extensive sanctions regimes targeting Russian oil and petroleum products. To circumvent these sanctions, Russia has increasingly relied on a parallel fleet operating without Western ties – a shadow fleet – which has come to play an important role in funding the Russian war effort. Shadow fleet vessels em

A novel geophysical methodology to characterize past metallurgic sites and deposits

This study is part of a North West Europe (NWE) Interreg project called NWE-REGENERATIS that aims at the regeneration of past metallurgic sites and deposits through innovative circularity for raw materials. A novel geophysical methodology is developed to allow a 2D or 3D characterization of the recoverable metallic particles in terms of volume, type and grain sizes. We propose to integrate multi-m

The private solution trap in collective action problems across 34 nations

Collective action problems emerge when individual incentives and group interests are misaligned, as in the case of climate change. Individuals involved in these problems are generally considered to have two options: contribute toward public solutions such as global warming mitigation or free ride. However, many collective action problems today involve a third option of investing in a “private solu

The Chinese Race to the Bottom : The Precarious Lives of Unemployed University Graduates in Beijing's "Ant Tribe"

This article is based on ethnographic fieldwork carried out among what Lian Si (2009) has called China’s ‘ant tribe’, referring to the millions of unemployed Chinese college graduates who live in the outskirts of Beijing and to some extent share the predicament of China’s migrant workers. Education has been the main route to social mobility for centuries in China, but today college graduates are o

Quantum Information and Computing for Beginners : Basics of Qubit Transformations and Quantum Algorithms

Quantum information and quantum computing are based on the concept and manipulation of qubits. In this pedagogical Tutorial-written with the aim of assisting self-motivated undergraduate mathematics, physics, and engineering students-transformation of these qubits, especially the Hadamard transformation (H) and the phase shifter transformation (φ), is illustrated. Two-qubit gates and their applica

Strategic improvisation in crisis communication

Falkheimer and Heide further develop their integration of improvisation into crisis communication. They argue that improvisation is a way to develop innovative thinking. Falkheimer and Heide argue crisis managers must adapt to new circumstances and situations making improvisation a value asset. Drawing from the leadership literature, they develop the idea of strategic improvisation. Strategic impr

Derivation of the Derjaguin approximation for the case of inhomogeneous solvents

The Derjaguin approximation (DA) relates the force between curved surfaces to the interaction free energy between parallel planes. It is typically derived by considering the direct interaction between the bodies involved, thus treating the effect of an intervening solvent implicitly by a rescaling of the corresponding Hamaker constant. Here, we provide a generalization of DA to the case of a molec

Comparative analysis on the film cooling mechanisms of elliptical and cylindrical holes with 90° compound angle

Purpose: In this study, numerical simulations are performed to compare the adiabatic film cooling effectiveness and reveal the difference of film cooling mechanisms of two models with the same geometries and cross-section areas of film holes’ exits at three typical blowing ratios (M = 0.5, 1 and 1.5). The two models are an elliptical model and a cylindrical model with 90° compound angle, respectiv