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Modern day crises demand organizations to collaborate and adapt to new roles, functions and structures. In such situations, lack of collaborative behaviour and openness between organizations can result in reduced adaptive ability. Therefore, it is important to facilitate collaboration between organizations.We have studied the extent to which crisis managers are prepared to work with personnel and
The ability to make specific perturbations to biological molecules in a cell or organism is a central experimental strategy in modern research biology. We have developed a general technique in which the stability of a specific protein is regulated by a cell-permeable small molecule. Mutants of the Escherichia coil dihydrofolate reductase (ecDHFR) were engineered to be degraded, and, when this dest
Resilience is becoming a prevalent agenda in safety research and organisational practice. In this study we examine how the peer-reviewed safety science literature (a) formulates the rationale behind the study of resilience; (b) constructs resilience as a scientific object; and (c) constructs and locates the resilient subject. The results suggest that resilience engineering scholars typically motiv
This article argues for the importance of explicit discussions of what is valuable as a foundation for any disaster risk reduction initiative to be effective. It does so by stating that it is impossible to talk about risk at all if not having some notion of uncertain potential impacts on something that humans value. What is assumed as valuable and important to protect is then determining what haza
We examined the transduction efficiency of different adeno-associated virus (AAV) capsid serotypes encoding for green fluorescent protein (GFP) flanked by AAV2 inverted terminal repeats in the nonhuman primate basal ganglia as a prelude to translational studies, as well as clinical trials in patients with Parkinson's disease (PD). Six intact young adult cynomolgus monkeys received a single 10 mu l
A conceptual framework for systematically studying and analysing risk governance is introduced. The framework, which is influenced by design science, is particularly valuable for relating the way risks are handled at the micro-level to aspects at the macro-level. Three central concepts are included in the framework: purpose, function, and form. A function is used to denote what a specific system d
To determine the incidence of anterior cruciate ligament (ACL) injuries in the general population; the pathology associated with a knee sprain verified by magnetic resonance imaging (MRI); and the agreement between clinical findings and MRI.Materials and methods: Inclusion criterion was an acute rotational trauma to the knee associated with effusion. One hundred and fifty-nine consecutive patients
The principal fate during litter decomposition and mineralization is rather well established only for a limited number of elements, mainly essential plant nutrients and a few potentially very toxic metals. Elements which occupy the majority of the positions in the periodical system seems almost unknown in this context. The objectives were, therefore to assess differences in the behavior of 58 mine
South Africa is a complex and dynamic society, with overwhelming and increasing problems with disaster risk in the vulnerable urban communities in and around its rapidly growing metropolitan centres. The purpose of this study is to improve the understanding of the challenges for disaster risk reduction in such communities. It focuses on the case of Imizamo Yethu, in the Western Cape, in order to b
Finger tapping to isochronous pacing stimuli is a well established experimental paradigm first described in the late 19th century. Two variables of common interest in rhythmic tapping tasks are timing variability and constant error. However, a difficulty when estimating these variables is that at interstimulus intervals longer than 2 seconds participants regularly overshoot the target interval and
Objective To compare, in young active adults with an acute anterior cruciate ligament (ACL) tear, the mid-term (five year) patient reported and radiographic outcomes between those treated with rehabilitation plus early ACL reconstruction and those treated with rehabilitation and optional delayed ACL reconstruction. Design Extended follow-up of prospective randomised controlled trial. Setting Ortho
Theorizing Power, by Jonathan Hearn, Basingstoke, Palgrave Macmillan, 2012, 264 pp., ISBN 9780230246560, £55.00 (hardback), ISBN 9780230246577, £19.99 (paperback).
BACKGROUND: Despite marked improvement in therapy and monitoring of patients with insulin-dependent (type 1) diabetes, diabetic nephropathy remains a serious complication, with subsequent end-stage renal disease in about 20% of cases. OBJECTIVE: To investigate in young patients with type 1 diabetes whether urine α-Glutathione S-transferase to creatinine ratio (α-GST:crea) relates to markers of s
BACKGROUND & AIMS: Little is known about recurrence of pancreatitis after an initial episode, and little is known about how the disease progresses or what factors affect progression. We performed a population-based study of patients with acute pancreatitis (AP) to determine their outcomes and associated factors. METHODS: We performed a retrospective study of patients with first-time AP from 20
Sex hormone-binding globulin (SHBG) is a glycoprotein responsible for the transport and biologic availability of sex steroid hormones, primarily testosterone and estradiol. SHBG has been associated with chronic diseases including type 2 diabetes (T2D) and with hormone-sensitive cancers such as breast and prostate cancer. We performed a genome-wide association study (GWAS) meta-analysis of 21,791 i
The expression and activities of constitutive nitric oxide synthase (cNOS) and inducible nitric oxide synthase (iNOS) in relation to insulin and glucagon secretory mechanisms were investigated in islets isolated from rats subjected to total parenteral nutrition (TPN) for 10 d. TPN is known to result in significantly increased levels of plasma lipids during the infusion time. In comparison with isl
Lyme borreliosis (LB) is the most common vector-borne disease in the northern hemisphere, and southern Sweden is a highly endemic area. In over 70% of the cases, LB is represented by the non-disseminated cutaneous form erythema migrans (EM). This thesis has its focus on EM from a primary health care perspective in southern Sweden, including aspects on epidemiology, the clinical picture, gender dif
This thesis consists of four theoretical essays on contingent claim analysis and its connection to Malliavin calculus. The first three papers are analyzed in the famous Black and Scholes model, while the setup of the fourth paper involves an international environment and the presence of exchange rates. In the first essay the tractability of the Malliavin calculus approach to derive the replicatin
