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BACKGROUND: Owing to the wide spread perception of a possible benefit from paclitaxel in the second-line situation the Nordic Gynecologic Oncology Group (NGOG) conducted two prospective phase II studies of paclitaxel single agent treatment (175 mg/m2, three-hour i.v. infusion with standard pre-medication every third week) in patients with relapsing or progressing epithelial ovarian cancer followin

BACKGROUND: De novo oligometastatic prostate cancer (omPCa) on prostate-specific membrane antigen (PSMA) positron emission tomography (PET) is a new disease entity and its optimal management remains unknown. OBJECTIVE: To analyze the outcomes of patients treated with cytoreductive radical prostatectomy (cRP) for omPCa on PSMA-PET. DESIGN, SETTING, AND PARTICIPANTS: Overall, 116 patients treated wi

We argue that the subject matter and objectives of risk science establish it as an inherently interdisciplinary field, closely connected to both academic disciplines and practical applications. However, risk research faces a range of interdisciplinary challenges. These include the production of low-quality research—characterised by superficial and insufficiently grounded conclusions—a lack of mutu

BACKGROUND: The period immediately following psychiatric inpatient care is recognized as a time of elevated risk of suicide, yet little is known about factors that influence how soon suicide occurs after discharge.AIM: To examine the timing of suicide among persons after psychiatric discharge and identify sociodemographic and clinical factors associated with a shorter time to death by suicide.METH

Essentially all academic research of today relies on analysis of data from a wide range of sources. Several underpinning, and rapidly developing, technologies are supporting the analysis of this data. Visualization serves as an interface to this ecosystem of tools and methods and integrates them into environments supporting scientific workflows, effectively sharing cognitive load between computers

BACKGROUND: Rapeseed is the second most cultivated oilseed globally after soybean and a protein-rich press cake is generated after liberation of the oil. However, its use in food applications is limited by high levels of anti-nutrients such as glucosinolates and phytic acid. Although differences between botanical varieties are known, controlled comparisons of modern spring varieties for protein fu

Soil microorganisms regulate carbon (C) cycling, and their growth and respiration are strongly dependent on temperature. Yet it remains unclear how warming alters microbial thermal traits, community structure, and the balance between microbial respiration and growth, particularly in subtropical ecosystems where high temperatures coincide with low soil moisture, potentially constraining microbial a

The reliability of a critical industrial component is decided by the durability of the weakest joint or spot. For applications involving high-temperature operational conditions especially coupled with corrosive environments like fuel cell interconnections, molten metal baths, etc., the joints are the most vulnerable regions for catastrophic failure due to localized material degradation by selectiv

Biological neural network functionality depends on the vast number of connections between nodes, which can be challenging to implement artificially. One radical solution is to replace physical wiring with broadcasting of signals between the artificial neurons. We explore an implementation of this concept by light emitting/receiving III-V semiconductor nanowire neurons in a quasi-2D waveguide. They

The article presents some results from an international project on the introduction of French literature in Scandinavia during the 19th century. A point of departure is the database BREFS (Bibliographie du Réalisme Français en Scandinavie), containing the translations of novels, short stories, poetic works and theatre plays that were published in Denmark, Finland, Iceland, Norway and Sweden in boo

In recent years, climate impact assessments of relevance to the agricultural and forestry sectors have received considerable attention. Current ecosystem models commonly capture the effect of a warmer climate on biomass production, but they rarely sufficiently capture potential losses caused by pests, pathogens and extreme weather events. In addition, alternative management regimes may not be inte

BACKGROUND: Certain immune-mediated diseases (IMDs), such as rheumatoid arthritis and systemic lupus erythematosus, have been linked to cardiovascular disorders. We examined whether there is an association between 32 different IMDs and risk of subsequent hospitalization for coronary heart disease (CHD) related to coronary atherosclerosis in a nationwide follow up study in Sweden. METHODS AND FIND

Popular Abstract in Swedish Blodflödet i livmoder- och navelsträngsartärerna påverkar bl a faktorer såsom tillväxt av livmoderns slemhinna, vidhäftningen av ägget och fostertillväxt. Det har betydelse för dessa funktioner både vid normal graviditet och vid tillstånd såsom t ex, havandeskapsförgiftning och tillväxthämning hos fostret. Blodflödet regleras av faktorer som inverkar på den glatta muskuThe serotonergic vascular control was investigated by in vitro pharmacology in the human uterine and umbilical arteries. The localisation of immunoreactive (IR) neuropeptide Y (NPY) and the influence of NPY on the adrenergic vascular effects in the human uterine artery were also studied. NPY-IR nerve fibres were observed predominantly at the media-adventitial border of the uterine artery. About 50

Popular Abstract in Swedish POPULÄRVETENSKAPLIG SAMMANFATTNING PÅ SVENSKA Brott på strålbenet på handledsnivå (handledsbrott) är en av de vanligaste orsakerna till att patienter måste uppsöka en akutmottagning. Skadan drabbar oftast medelålders och äldre kvinnor. Skelettet blir skörare hos kvinnor efter klimakteriet, vilket lättare leder till ett benbrott. Medan brott på lårbenshalsen oftast drabABSTRACT Fractures of the distal radius are common injuries that may cause persistent disability and pain. This thesis prospectively investigates the incidence and characteristics of distal radius fractures, the relationship between fracture malunion and disability and the natural course of patient-reported outcome after fracture in a well-defined population in Northeastern Scania, Sweden. Further

IMPORTANCE Bipolar disorder is associated with premature mortality, but the specific causes and underlying pathways are unclear. OBJECTIVE To examine the physical health effects of bipolar disorder using outpatient and inpatient data for a national population. DESIGN, SETTING, AND PARTICIPANTS National cohort study of 6 587 036 Swedish adults, including 6618 with bipolar disorder. MAIN OUTCOMES AN

The best way to conceive semiotical spaces that are not identical to single buildings, such as a cityscape, is to define the place in terms of the activities occurring there. This conception originated in the proxemics of E. T. Hall and was later generalized in the spatial semiotics of Manar Hammad. It can be given a more secure grounding in terms of time geography, which is involved with trajecto

This paper deals with the role of a journal's publisher country in determining the expected citation rates of the articles published in it. We analyze whether a paper has a higher citation rate when it is published in one of the large publisher nations, the U.S., U.K., or the Netherlands, compared to a hypothetical situation when the same paper is published in journals of different origin. This wo

Popular Abstract in Swedish I Sverige har andelen förtidspensionärer ökat under lång tid och uppgick år 1998 till 7.6% av befolkningen i arbetsför ålder (16-64 år). Den vanligaste orsaken till att en individ förtidspensioneras är reducerad arbetsförmåga till följd av problem i rörelseorganen. Kunskaperna om förtidspensionärers livskvalitet är bristfälliga. Syftet med denna studie var att studera lThe starting-point of this thesis was the high rate of disability pensioners in Sweden and the lack of knowledge about what a disability pension entails for quality of life (QL). The aim of the study was to gain knowledge about QL among disability retirees with musculoskeletal disorders (ERPs). A questionnaire was sent in 1992 to 450 ERPs in Kristianstad Municipality, Sweden, granted their disabil