Filetype
High-risk neuroblastoma (NB) is a rare, solid childhood cancer with poor prognosis due to treatment resistance and metastasis. Improved patient outcome is dependent on the understanding of the resistance mechanisms and subsequent development of novel treatment options.In Paper I, we established a clinically relevant in vivo treatment protocol using current standard-of-care chemotherapy (COJEC). We
Parser generators are an indispensable tool for rapid language devel- opment. However, they often fall short of the finesse of a hand-crafted parser, built with the language semantics in mind. One area where generated parsers have pro- vided unsatisfactory results is that of error recovery. Good error recovery is both natural, giving recovery suggestions in line with the intention of the programme
Transmission of respiratory viruses is a complex process involving emission, deposition in the airways, and infection. Inhalation is often the most relevant transmission mode in indoor environments. For severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the risk of inhalation transmission is not yet fully understood. Here, we used an indoor aerosol model combined with a regional inhaled
Aim: To assess available evidence on the use of rFVIIa in non-orthopaedic surgery including dental surgery in adult patients with congenital haemophilia with inhibitors (PWHI). Methods: A systematic literature search was performed according to a prespecified search string; prespecified criteria were used to select applicable studies including PWHI ≥18 years of age who underwent any non-orthopaedic
The Common Agricultural Policy (CAP) is the largest budget item in the European Union, but varied data reporting hampers holistic analysis. Here we have assembled the first dataset to our knowledge to report individual CAP payments by standardized CAP funding measures and geolocation. We created this dataset by translating, geolocating to the county or province (NUTS3) level, and consistently harm
Kidney Exchange Programs (KEP) are valuable tools to increase the options of living donor kidney transplantation for patients with end-stage kidney disease with an immunologically incompatible live donor. Maximising the benefits of a KEP requires an information system to manage data and to optimise transplants. The data input specifications of the systems that relate to key information on blood gr
The shift toward battery electric vehicles (EVs) represents the most profound disruption in the automotive industry in over a century, with far-reaching consequences for European automotive regions. For decades, incremental improvements in internal combustion engine (ICE) technologies have served as the dominant decarbonization pathway, and many regions have built strong innovation systems around
The development of new therapies for the treatment of type 2 diabetes requires robust, reproducible and well validated in vivo experimental systems. Mice provide the most ideal animal model for studies of potential therapies. Unlike larger animals, mice have a short gestational period, are genetically similar, often give birth to many offspring at once and can be housed as multiple groups in a sin
Idiopathic Parkinson's disease (PD) is a multisytem degenerative disorder. In addition to motor symptoms such as akinesia, rigidity and tremor, various non-motor symptoms occur, which are still insufficiently diagnosed. Moreover, the frequently used scales and scores do not adequately detect these non-motor symptoms. The Non-motor Symptoms Questionnaire (NMSQuest) is an established self-completed
Learning from incidents is important for improving safety. Many companies spend a great deal of time and money on such learning procedures. The objectives of this paper are to present some early results from a project aimed at revealing weaknesses in the procedures for learning from incidents and to discuss improvements in these procedures, especially in chemical process industries. The empirical
The effects of high optical depth phenomena, such as superradiance, are investigated in potential quantum memory materials. The results may have relevance for several schemes, including controlled reversible inhomogeneous broadening, atomic frequency combs, and quantum memories based on electromagnetically induced transparency, which are based on using ensembles as storage media. It is shown that
Objectives: Familial Clustering of a disease is an indicator of a possible heritable Cause. provided that environmental sharing can be excluded. Thus. data on familial risks are important For genetic Studies and for clinical genetic counseling. Design: We carried Out a nationwide family study on nontoxic and toxic nodular goiters, and Graves' disease in order to search for familial clustering of t
Following decades of detailed kinetic and spectroscopic evidence, two new, independent X-ray structures for the cytochrome b(6)f complex of photosynthesis now reveal the arrangement of its key electron carriers relative to each other, and to their protein ligands. But these are not predictable additions to the structural collection. The complex is dimeric, and encloses a central chamber in which p
Cell replacement therapy in Parkinson's disease (PD) has so far been based on the use of primary dopaminergic (DA) neuroblasts obtained from the brain of aborted human fetuses. Clinical trials show that intrastriatal DA neuron transplants can give substantial symptomatic relief in advanced PD patients. Two recent NIH-sponsored placebo-controlled trials, however, have given disappointing results an
BACKGROUND: For 40 years cricoid pressure has been used to prevent regurgitation of gastric contents during induction of anaesthesia. Recent studies have emphasised use of more moderate force so as not to deteriorate ventilation or endotracheal intubation. This study was undertaken to assess the current practice and knowledge of cricoid pressure among anaesthesia personnel in southern Sweden. METH
Employment restrictions have been experienced by many people with epilepsy. In many cases, the restrictions are unjustified and based on stigma or a stereotypical image of the person with epilepsy. Unjustifiable restrictions are a form of discrimination and lead to unemployment and underemployment. Unfortunately, much of the research in this area has been difficult to interpret because of differen
The concept of a fair and optimal allocation was recently introduced by Sun and Yang [Sun, N., Yang, Z., 2003. A general strategy proof fair allocation mechanism. Economics Letters 81, 73-79]. This note states some basic properties of fair and optimal allocations and provides a simple algorithm for identifying them. (C) 2007 Elsevier B.V. All fights reserved.
