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The Relativistic Heavy Ion Collider (RHIC) has made it possible to study hadronic matter under unprecedented conditions in terms of temperature and energy density. Global variables are essential for the characterization of nuclear collisions at ultra-relativistic energies. The PHENIX experiment has several detectors which provide information about the global properties and hence the initial condit
Popular Abstract in Swedish Melamisufism (melamet) fanns i olika delar av Osmanska riket. Den sista perioden, då melamirörelsen var särskilt märkbar, tar sin början i slutet av 1800-talet, och då med en koncentration i den europeiska delen av det osmanska riket (Rumeli). Detta hänger samman med att melamiordens huvudschejk Sejjid Muhammed Nur el-Arebi, bodde och var verksam där under denna tid. MeThis dissertation focuses on Melami history in Bosnia with emphasis on the 20th century. The well-known Melami master Hajrullah Abdurahmanovic (d. 1965) in this study becomes an exponent for changes in the political and social role of religion in course of the 20th century. The purpose of this research is to describe and analyze the theology of the Melami movement in the environments created by su
Context: The diagnosis of late-onset hypogonadism (LOH) in older men with age-related declines in testosterone (T) is currently not well characterized. Objective: Our objective was to investigate whether different forms of hypogonadism can be distinguished among aging men. Design: The study was a cross-sectional survey on 3369 community-dwelling men aged 40-79 yr in eight European centers. Methods
Context: Limited data are available exploring the associations between sex hormones, multiple domains of sexual functioning, and sexual function-related distress in nonpatient samples in Europe. Objectives: The aim of the study was to investigate the relationships between serum testosterone (T), estradiol (E2), and dihydrotestosterone (DHT) and sexual function in a multicenter population-based stu
Context: It has been shown that mitochondrial DNA (mtDNA) content is associated with type 2 diabetes (T2D) and related traits. However, empirical data, often based on small samples, did not confirm this observation in all studies. Therefore, the role of mtDNA content in T2D remains elusive. Objective: In this study, we assessed the heritability of mtDNA content in buccal cells and analyzed the ass
For a CD8 epitope-based vaccine to match different geographic locations, the targeted epitopes for cytotoxic T-lymphocytes (CTLs) must be present in the local circulating HIV-1 strains. Secondly, the vaccine epitopes should match the host population HLA types. We characterized two new HIV-1 isolates from Guinea-Bissau. Also, we have identified 15 subdominant CD8 epitopes representing common HLA su
Antibody binding sites provide an adaptable surface capable of interacting with essentially any molecular target. Using CDR shuffling, residues important for the assembly of mucin-1 specific paratopes were defined by random recombination of the complementarity determining regions derived from a set of mucin-1 specific clones, previously selected from an antibody fragment library. It was found that
Context:Late-onset hypogonadism (LOH) has been defined as a syndrome in middle-aged and elderly men reporting symptoms in the presence of low testosterone (T). Objective:The objective of the study was to seek objective biochemical and end-organ evidence of androgen deficiency in men classified as having LOH according to our previously published criteria. Design, Setting, and Participants:The des
Vorinostat is a histone deacetylase inhibitor that changes gene expression and protein activity. On the basis of the clinical benefit reported in patients with malignant pleural mesothelioma treated in a phase 1 study of vorinostat, we designed this phase 3 trial to investigate whether vorinostat given as a second-line or third-line therapy improved patients' overall survival.
Fluorescence microscopy is introduced as a low cost quality control process for nanoimprint lithography. To depict imprinted structures down to 1 mum lateral size and to detect residues down to 100 nm lateral size, the standard printable polymer mr-18000 is labelled with less than 0.1 wt.% fluorescent dye. Three different types of stamps are used to determine the dependence of the shape and size o
Background General adiposity, assessed by body mass index (BMI), is a well-established cancer risk factor. This study compared waist circumference (WC), a measure of abdominal adiposity, with BMI as a risk factor for obesity-related cancers, and assessed whether WC provides additional information beyond BMI. Methods We analyzed data from 339 190 individuals in a pooled Swedish cohort with baseline
Despite recent progress within the field of immuno-oncology, immune suppression in the tumor microenvironment, defective antigen presentation, and low levels of tumor-specific T cells are key limitations of current cancer immunotherapies. CD40-targeting immunotherapies hold promises for addressing these limitations across solid tumors. Here, we describe ATOR-4066, a bispecific antibody that target
Dynamic Resource Management (DRM) facilitates the real-time adjustment of resources allocated to a job during its execution. Recently, DRM has gained interest due to its potential to contribute to sustainable HPC by enhancing energy efficiency and increasing throughput for HPC system providers and users. Implementing DRM requires comprehensive changes and coordination across the entire HPC softwar
Agentic AI — the new paradigm for creating autonomous systems capable of perceiving, reasoning, learning, and acting towards goals using large language models (LLMs) with minimal human oversight — offers transformative potential but also poses systemic risks that the EU AI Act only partially addresses. These agents can evolve unpredictably, interact with other agents, and operate beyond meaningful
Patients with chronic lymphocytic leukemia (CLL) have an impaired response to vaccination, which calls for improved vaccination strategies. This study aimed to evaluate antibody persistence 5 years after pneumococcal vaccination and response to revaccination. Seventy-four CLL patients and 31 controls, all primary immunized with 13-valent conjugated pneumococcal vaccine (PCV13) or 23-valent polysac
Despite significant progress in oncology research, pancreatic cancer remains inherently difficult to treat, and the mechanisms underlying therapeutic resistance remain unresolved. Decorin (DCN), a member of the family of small leucine-rich proteoglycans, has emerged as a versatile actor in various malignant diseases. The aim of this study was to further explore the potential clinical significance
