Filetype
Secretagogin is a hexa EF-hand protein, which has been identified as a novel potential tumour marker. In the present study, we show that secretagogin binds four Ca2+ ions (log K-1 = 7.1 +/- 0.4, log K-2 = 4.7 +/- 0.6, log K-3 = 3.6 +/- 0.7 and log K-4 = 4.6 +/- 0.6 in physiological salt buffers) with a [Ca2+](0.5) of approx. 25 mu M. The tertiary structure of secretagogin changes significantly upo
Popular Abstract in Swedish Denna avhandling är resultatet av ett doktorandprojekt vid Kvartärgeologiska avdelningen, Lunds Universitet. Syftet med undersökningen var att rekonstruera vegetations- och klimatförändringar under de senaste 10 000 åren i Torneträskområdet i norra Sverige. Resultatet bygger på analyser av pollen och växtmakrofossil från 6 sjöar belägna på olika höjd över havet (370-999The aim of this study was to reconstruct the Holocene vegetation history and the climate changes in a subarctic area. The results are based on pollen and macrofossil records from six lakes in the Torneträsk area. The lakes are situated at altitudes between 370 and 999 m a.s.l., along a transect from the boreal pine-birch forest to the alpine tundra with heath vegetation. The chronology in each lak
Allopolyploidization often happens recurrently, but the evolutionary significance of its iterative nature is not yet fully understood. Of particular interest are the gene flow dynamics and the mechanisms that allow young sibling polyploids to remain distinct while sharing the same ploidy, heritage and overlapping distribution areas. By using eight highly variable nuclear microsatellites, newly rep
Why do certain firms prosper and grow old while other firms fail? Established knowledge tells us that longevity is related to the firm's ability to adapt to market conditions, through product diversification, learning-by-doing and adopting new strategies regarding technology, human resources and management. By estimating duration models using new data covering the entire Swedish tobacco industry,
We present here a dynamical method for modelling temporal and geographical variations in ammonia emissions in regional-scale chemistry transport models (CTMs) and chemistry climate models (CCMs). The method is based on the meteorology in the models and gridded inventories. We use the dynamical method to investigate the spatiotemporal variability of ammonia emissions across part of Europe and study
Larger amounts of variable renewable energy sources bring about larger amounts of uncertainty in the form of forecast errors. When taking operational and planning decisions under uncertainty, a tradeoff between risk and costs must be made. Today's deterministic operational tools, such as N-1-based methods, cannot directly account for the underlying risk due to uncertainties. Instead, several defin
This paper presents a study in which the specific activity of (14)C in hair has been investigated as an easily determined bio-indicator of the integrated (14)C exposure (over several months). The study includes 28 Swedish workers handling (14)C-labelled compounds, or working in a (14)C-enriched environment. Hair samples from personnel at a Swedish nuclear power plant showed very low levels of (14)
The terrestrial biosphere is a key regulator of atmospheric chemistry and climate. During past periods of climate change, vegetation cover and interactions between the terrestrial biosphere and atmosphere changed within decades. Modern observations show a similar responsiveness of terrestrial biogeochemistry to anthropogenically forced climate change and air pollution. Although interactions betwee
Background. Congenital cytomegalovirus (CMV) is an important cause of neurological problems, particularly sensorineural hearing loss, but data on long-term sequelae and the impact of nonprimary maternal infection are limited. We report updated findings on childhood outcomes from 2 large prospective studies. Methods. Pregnant women in Malmo, Sweden, and London, United Kingdom, were included between
The strong association between t(14;18) translocation and follicular lymphoma (FL) is well known. However, the determinants of this chromosomal aberration and their role in t(14;18) associated FL remain to be established.
Since the first heart transplantation (HT) in 1967, survival has steadily improved. Issues related to over- and under-immunosuppression are, however, still common following HT. Whereas under-immunosuppression may result in rejection, over-immunosuppression may render other medical problems, including infections, malignancies and chronic kidney disease (CKD). As such complications constitute major
This article critiques the notion of a cross-national convergence of institutional and policy responses to science-based technologies. The continued significance of institutional legacies is demonstrated through a comparative analysis of strategies for the biopharma industry in two radically different settings: India and the European Union (EU). Tensions are evident in both the EU 'high' route and
The ATP-binding cassette (ABC) of active transporters comprises a group of proteins that which facilitate efflux of anticancer drugs from cancer cells. We focused on the gene amplification and protein expression of ABCC3 (also known as MRP3) in breast cancer cell lines and clinical tumor samples. Fluorescence and chromogenic in situ hybridization, using an ABCC3-specific probe, was used to analyze
The climatic conditions inside nuclear reactor containments are continuously monitored by the plant owners in order to e.g. maintain a suitable climate for the mechanical and electrical equipment. Due to the high temperatures, during operation, the concrete within the containment may act as a moisture source contributing to the humidity. To evaluate if, and to what extent, the concrete inside the
ECG markers derived from the P-wave are used frequently to assess atrial function and anatomy, e.g. left atrial enlargement. While having the advantage of being routinely acquired, the processes underlying the genesis of the P-wave are not understood in their entirety. Particularly the distinct contributions of the two atria have not been analyzed mechanistically. We used an in silico approach to
Landslides of contaminated soil into surface water represent an overlooked exposure pathway that has not been addressed properly in existing risk analysis for landslide hazard, contaminated land, or river basin management. A landslide of contaminated soil into surface water implies an instantaneous exposure of the water to the soil, dramatically changing the prerequisites for the mobilisation and
Dynamic global vegetation models (DGVMs) are important tools for modelling impacts of global change on ecosystem services. However, most models do not take full account of human land management and land use and land cover changes (LULCCs). We integrated croplands and pasture and their management and natural vegetation recovery and succession following cropland abandonment into the LPJ-GUESS DGVM.
We examine the role of substitution from traditional to modern energy carriers and of differential rates of innovation in the use of each of these in economic growth in Sweden from 1850 to 1950. We use a simple growth model with a nested CES production function and exogenous factor-augmenting technological change and carry out a counterfactual simulation based on the econometric results. Even thou
