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The influential role of Wnt5a in tumor progression underscores the requirement for developing molecules that can target Wnt5a-mediated cellular responses. In the aggressive skin cancer, melanoma, elevated Wnt5a expression promotes cell motility and drives metastasis. Two approaches can be used to counteract these effects: inhibition of Wnt5a expression or direct blockade of Wnt5a signaling. We hav

A supramolecular complex composed of Ru(II) tris-bipyridine, tyrosine, and dipicolylamine was synthesized and characterized. This complex was attached to TiO2 nanocrystalline films via ester groups at the Ru(II) chromophore, and photoinduced multistep electron transfer was investigated by laser flash photolysis and electron paramagnetic resonance techniques. Following ultrafast electron injection

Autoimmune T cell responses directed against insulin-producing β cells are central to the pathogenesis of type 1 diabetes (T1D). Detection of such responses is therefore critical to provide novel biomarkers for T1D 'immune staging' and to understand the mechanisms underlying the disease. While different T cell assays are being developed for these purposes, it is important to optimize and standardi

OBJECTIVE: Topical negative pressure therapy has excellent healing effects in poststernotomy mediastinitis. Topical negative pressure therapy reduces bacterial counts, increases wound edge microvascular blood flow and granulation tissue formation, and facilitates healing. No study has yet been performed to examine the effect of topical negative pressure on the blood and fluid content in the sterna

Aims In a cohort of men and women with Type 1 diabetes, prospectively followed for > 20 years, vibrotactile sense in fingers was investigated and related to neurophysiological tests, glycaemic level and clinical score. Methods Out of 58 patients, diagnosed at the age of 15-25 years and recruited 1984-1985, 32 patients (13 women, median age 52 years, range 44-75 years; 19 men, median age 52 years,

Syftet med vår studie är att undersöka de problem som kan uppstå vid en överföring av ett styrinstrument, innehållande Key Performance Indicators, från en organisation till en annan i samband med förvärv. Uppsatsen utgår från en fallstudie av ett företag i kemibranschen. I vår fallstudie använder vi ett abduktivt angreppssätt och en kvalitativ metod. I den teoretiska referensramen utgår vi ifrån t

Det här examensarbetet behandlar den akustiska utformningen av simhallar. Fokus ligger på de lösningar som påverkar akustiken, så som väggar, absorbenter och utformningen. Grunden till arbetet är baserat på befintlig litteratur och ny information framtaget för arbetet. Simhallar är en svår akustisk lokal där många hårda ytor och stora volymer försvårar. Detta ger en ljudmiljö med hög ljudnivå ochThe Master thesis considers acoustic design of swimming halls. Focus is put into design solutions affecting the acoustic environment such as walls, absorbents and shape. The basis is gained from literature studies and new information achieved specific for the thesis. Swimming halls are built in a certain way that makes a good acoustic environment hard to achieve. The construction consists of hard

The decreasing extent of the Arctic sea ice has opened up new areas in the High North for industrial and commercial activities. These areas contain large reserves of oil and gas, and the region is home to some of the world’s richest fishing grounds. The region is of key strategic importance, and maintaining a Norwegian presence in the Arctic areas is considered to be a national priority. A major r

Marine debris is a major threat to wildlife and human health. This study examines the socioeconomic vulnerability of informal housing as arguably one of the main drivers of the abundance of marine debris in the aftermath of a tropical cyclone. Using the Abaco Islands, Bahamas, as a case, the study applies the capabilities approach to assess the societal impact of Hurricane Dorian. Findings indicat

Under år 2015 antog regeringen en ändring av brottsbalken (BrB, 1962:700) som ger rätten en möjlighet att erkänna strafflindring i fall där den tilltalade medverkar till utredningen av sin egen brottslighet (29 kap. 5 a § 1 st. BrB). Fastän ändringen hade önskvärda syften, bland annat en ökad effektivitet, är rätten att inte belasta sig själv en generell och grundläggande rättighet som inte får glIn 2015, the Swedish government adopted an amendment of the Swedish Criminal Code (brottsbalken, 1962:700) which grants the court a possibility to reduce the penalty in cases where the defendant contributes to the investigation of their own crime (chapter 29 § 5 a 1). While the rationale behind the amendment lies upon desirable arguments such as efficiency, the privilege against self-incrimination

The thesis covers human rights violations against persons with disabilities, focusing on their right to political life and the right to vote, using the framework of critical disability theory. The aim of the thesis is two-folded: it analyses the use of the UN Convention on the Rights of Persons with Disabilities (CRPD) in the adjudication of the European Court of Human Rights (ECtHR) with a focus

Purpose: The purpose of this study is to investigate how a brand’s packaging design becomes iconic through entering pop culture/art. Design/methodology/approach: This paper is of qualitative nature, based on a traditional literature review along with multiple case-study research. This approach allows for deep analysis into the dimensions of iconic packaging. Finally, template analysis was made to

Oklarhetsregeln är en avtalsrättslig princip som härstammar från den romerska rätten och återfinns i flera rättsordningar och internationella principsamlingar. I Corpus Juris Civilis är den latinska formuleringen av regeln ambiguitas contra stipulatorem est och på engelska omnämns den som the contra proferentem rule. Även om oklarhetsregeln är en välkänd princip, är den kontroversiell. HD har exemThe contra proferentem rule is a legal doctrine in contract law, which originates from the Roman law. Today, the rule is known in several legal systems and is used in international collections of principles. In Corpus Juris Civilis the Latin wording of the rule is ambiguitas contra stipulatorem est and in Sweden the rule is known as oklarhetsregeln. Even though the rule is well known, it is contro

Vid den nordöstra kusten av den karibiska ön Grenada ligger en övergiven flygplats. Denna extraordinära miljö ligger i en dal mellan tropiska berg täckta av frodig regnskog. Landningsbanan är en 1,5 kilometer lång historisk startbana som möter Atlantens livfulla vatten. Grenada har redan drabbats av orkaner och andra tropiska stormar. Utvecklingen av klimatförändringar skapar oftare och mer intenOn the north east coast of the Caribbean island Grenada, there´s an abandoned airport. This extraordinary environment is located in a valley between tropical mountains covered by lush rain forest. The landing stripe is a 1,5-kilometer-long runway of history, facing the rough Atlantic Ocean. Grenada has already suffered badly from hurricanes and tropical storms. While climate changes are evolving

The thesis concentrates on the issue of bill of lading fraud and discusses legal remedies as to respective type of fraud. Due to complexity and difference of each jurisdiction, the thesis selects English law and Chinese law as targeted jurisdiction, under which the issue of bill of lading will be addressed and analyzed. In addition to domestic law, the recent-adopted international convention, name

Abstract Authors: Cornelia Hultberg & Belma Jukovic Title: The minority law from 2010 – a study consisting the young Roma adults perceptions of the law. [Translated title] Supervisor: Helena Hansson Assesor: Anders Östnäs The purpose of this paper was to examine which perception some young adults with a Roma background in Sweden have about the minority law from 2010. The study was based on in

Powwow is a gathering of North America`s native people. North American native people meet to dance, sing, socialize and honor Native American culture. The thesis seeks to understand why the North American natives uses powwow as a way of manifesting their identity and cultural affiliation. The thesis also seeks to understand how the North American natives and the powwow movement is represented at t

The normal approach to digital control is to sample periodically in time. Using an analog of integration theory we can call this Riemann sampling. Lebesgue sampling or event based sampling is an alternative to Riemann sampling. It means that signals are sampled only when measurements pass certain limits. In this paper it is shown that Lebesgue sampling gives better performance for some simple syst

We report on studies of the formamidinium lead triiodide (FAPbI3) perovskite film using time-resolved terahertz (THz) spectroscopy (TRTS) and flash photolysis to explore charge carriers generation, migration, and recombination. The TRTS results show that upon femtosecond excitation above the absorption edge, the initial high photoconductivity (∼75 cm(2) V(-1) s(-1)) remains constant at least up to