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Popular Abstract in Swedish SVENSK SAMMANFATTNING Den kliniska effekten av läkemedel som administreras till näsa eller lunga beror på läkemedlets egenskaper och på dess lokala deposition. Depositionsstudier är därför värdefulla för att kunna karakterisera olika beredningar. Depositionen påverkas av partiklarnas storlek och hastighet, genom att stora partiklar med hög hastighet ger upphov till en hThe local deposition, pharmacokinetics, and systemic activity of inhaled and intranasal glucocorticosteroids in different formulations and devices(ICSs) has been investigated. After nasal administration of the ICS budesonide (Bud), the systemic availability (F) was found to be significantly higher from an aqueous pump spray and from the powder inhaler Turbuhaler, than from a pressurized metered do

Mitochondrial permeability transition (MPT) is induced in isolated brain mitochondria by calcium and oxidants and is inhibited by adenine nucleotides. When induced, MPT is associated with equilibration of solutes of <1500 Da across the inner mitochondrial membrane. A persistent induction of MPT depolarizes the inner membrane and causes cessation of ATP synthesis, swelling of the matrix, and bursti

This doctoral thesis has its theoretical origin in the notion that the information flow between management teams, financial analysts and investors is especially exposed to information asymmetry when knowledge-intense companies are concerned. Information asymmetry may aggravate agency problems and risk causing an impairment of the efficient allocation of capital on the stock market. Therefore, the

Background: The Clubfoot Assessment Protocol (CAP)is a multi dimensional instrument designed for longitudinal follow up of the clubfoot deformity during growth. Item reliability has shown to be sufficient. In this article the CAP's validity and responsiveness is studied using the Dimeglio classification scoring as a gold standard. Methods: Thirty-two children with 45 congenital c

This article analyses the doctrine of free will (autexousion) in the confessions of St. Peter Mogila and Dositheos II Notaras of Jerusalem. Free will is a central concept in Eastern Christian anthropology and these two monuments of theology represent how the understanding of the concept of free will developed in Eastern Orthodox theology in the context of the confrontation with Western theologies

Development and optimization of the production of lactic acid bacteria (LAB) and their attendant 'natural' inhibitors as biopreservatives to control undesirable bacteria currently remains a primary focus of several laboratories involved in research concerning food safety and quality. Strategies utilized to study incorporation of biopreservatives into food include either direct use of LAB-strains o

Popular Abstract in Swedish I hjärnan finns ett fantastiskt effektivt kontrollsystem för utförandet av olika typer av rörelser. Lillhjärnan är en viktig del av detta kontrollsystem eftersom skador på lillhjärnan kan leda till att fint styrda rörelser blir svårare eller kanske helt omöjliga att utföra. En förståelse av lillhjärnans funktion kan därför leda till en bättre generell förståelse av hur A modular organization has recently been described for the cerebellar control system comprising the forelimb areas of the C1/C3/Y zones in the cerebellar cortex and nucleus interpositus anterior (NIA) of the cat. A module is a group of cells in NIA which receives homogenous climbing fibre input via Purkinje cells that belong to the same set of microzones in the C1/C3/Y zones. The organization of i

Popular Abstract in Swedish Jorden är ett ytterst komplext och dynamiskt system. Livet har format planeten och utvecklats i takt med förändrade livsvillkor. Ekosystemen kontrolleras i hög grad av klimatet. Snabbt förändrade villkor innebär betydande påfrestningar för åtskilliga arter och ekosystem, inklusive planetens mest dominerande art, människan. Avhandlingens huvudfokus är att undersöka samsThe Earth is a highly complex and dynamic system. Life has shaped the entire planet and evolved in response to living conditions. Ecosystems are heavily affected by climate. Rapidly changing conditions imply considerable stress on several species and ecosystems, as well as to the most dominant species on the planet. The main focus of this thesis is to investigate climate and anthropogenic interac

This paper describes in what ways hierarchical organizations influence the utilization and dissemination of knowledge. Particular attention will be paid to the role that tacit knowledge has. The reporting system of incidents is one element in a larger institutional process, often termed 'lessons learned' (LL). This process helps to suggest solutions to identify shortcomings and facilitates in maki

The Conference on Computational Natural Language Learning is accompanied every year by a shared task whose purpose is to promote natural language processing applications and evaluate them in a standard setting. In 2008 the shared task was dedicated to the joint parsing of syntactic and semantic dependencies. This shared task not only unifies the shared tasks of the previous four years under a uniq

Woolly mammoths had a set of adaptations that enabled them to thrive in the Arctic environment. Many mammoth-specific single nucleotide polymorphisms (SNPs) responsible for unique mammoth traits have been previously identified from ancient genomes. However, a multitude of other genetic variants likely contributed to woolly mammoth evolution. In this study, we sequenced two woolly mammoth genomes a

Following years of increasing bureaucracy and micro-management, there is a need for more trust in the judgement of street-level professionals and citizens in the public administration. After an intense debate in Sweden for several years, the Swedish Government launched a trust reform in 2016. This was organized around a government commission, called the Trust Commission. At the centre of its work

After a 7-year slowdown in economic growth in the previous decade, LAC opened this decade with the adverse effects of Covid. The economic slowdown and the health crisis jeopardized the SDGs’ implementation in the region. In this chapter, the authors revisit the old question of whether the previous decade of LAC is another lost decade, mainly adding the environmental dimension to the economic and s

Aquaporin-9 (AQP9) is a facilitator of glycerol and other small neutral solute transmembrane diffusion. Identification of specific inhibitors for aquaporin family proteins has been difficult, due to high sequence similarity between the 13 human isoforms, and due to the limited channel surface areas that permit inhibitor binding. The few AQP9 inhibitor molecules described to date were not suitable