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CD1-dependent regulation of chronic central nervous system inflammation in experimental autoimmune encephalomyelitis.

The existence of T cells restricted for the MHC I-like molecule CD1 is well established, but the function of these cells is still obscure; one implication is that CD1-dependent T cells regulate autoimmunity. In this study, we investigate their role in experimental autoimmune encephalomyelitis (EAE), an animal model for multiple sclerosis, using CD1-deficient mice on a C57BL/6 background. We show t

Justifying interventions-The case of ECOWAS in Liberia

In contrast to the other chapters in Part V, Nina Wilén’s focus is on multilateral military interventions at the regional level: She explores the relationship between sovereignty, intervention, and the international normative order, by examining how ECOWAS, an African regional organization, justified its intervention in Liberia’s civil war referring to international norms. Based on a critical disc

Early Math in a Preschool Context : Spontaneous Extension of the Digital into the Physical

The paper presents a systematic examination of data from two early math interventions, involving 188 children aged 3,5-6,5 and their teachers. The aim is to cast light on how a digital early math game can be spontaneously extended into the physical environment by children and by teachers. Questions were: i) how the math content was extended to the physical room, ii) which elements of the game and

A-769662 inhibits adipocyte glucose uptake in an AMPK-independent manner

Activation of AMP-activated protein kinase (AMPK) is considered a valid strategy for the treatment of type 2 diabetes. However, despite the importance of adipose tissue for whole-body energy homeostasis, the effect of AMPK activation in adipocytes has only been studied to a limited extent and mainly with the AMP-mimetic 5-aminoimidazole-4-carboxamide-1-b-d-ribofuranoside (AICAR), which has limited

Considerable variation of trough β-lactam concentrations in older adults hospitalized with infection—A prospective observational study

In older adults, few studies confirm that adequate concentrations of antibiotics are achieved using current dosage regimens of intravenous β-lactam antibiotics. Our objective was to investigate trough concentrations of cefotaxime, meropenem, and piperacillin in older adults hospitalized with infection. We included 102 patients above 70 years of age. Total trough antibiotic concentrations were meas

Butterflies fly using efficient propulsive clap mechanism owing to flexible wings

Butterflies look like no other flying animal, with unusually short, broad and large wings relative to their body size. Previous studies have suggested butterflies use several unsteady aerodynamic mechanisms to boost force production with upstroke wing clap being a prominent feature. When the wings clap together at the end of upstroke the air between the wings is pressed out, creating a jet, pushin

Preferred sound groups of vocal iconicity reflect evolutionary mechanisms of sound stability and first language acquisition : evidence from Eurasia

In speech, the connection between sounds and word meanings is mostly arbitrary. However, among basic concepts of the vocabulary, several words can be shown to exhibit some degree of form–meaning resemblance, a feature labelled vocal iconicity. Vocal iconicity plays a role in first language acquisition and was likely prominent also in pre-historic language. However, an unsolved question is how voca

Morphometric analysis of disjunct Papaver radicatum (Papaveraceae) populations in southern Norway

Morphometric relationships between populations of Papaver radicatum within the southern Norwegian mountains were investigated using canonical variates analysis and Ward's clustering on capsule and leaf character sets. The survey describes patterns of variation among 13 wild-scored populations from five geographically disjunct localities, usually assigned to five races or subspecies. Our results fr

EFFECT OF KIDNEY STEM CELLS ON BIOCHEMICAL ANALAYSIS AND SMAD2/3 PHOSPHORYLATION IN RATS WITH DIABETIC NEPHROPATHY

Introduction: Mesenchymal stem cells (MSCs) were proposed as a critical therapeutic candidate in diabetic nephropathy (DN). Renal stem cells as a source for repairing are controversial. The purpose of the present study was to evaluate the effect of kidney rat stem cells on DN. Materials and methods: After separation of renal stem cells from rat kidney, the surface Stem cell markers were assessed b

Four-decade dynamics of the water color in 61 large lakes on the Yangtze Plain and the impacts of reclaimed aquaculture zones

The lakes on the Yangtze Plain, a critical source of freshwater and fisheries for hundreds of millions of people in China, have lost a considerable portion of their surface area due to reclamation since the 1950s. Landsat satellites can provide long-term collections of high-resolution images and thus offer great potential for hindcasting the lake reclamations of aquaculture zones and their long-te

Lessons Learned from a Study on Distractions in Virtual Learning Environments : Reliability, Ecological Validity, and an Elusive Social Component

Virtual Reality has long been proposed to combine the reliability of controlled laboratory settings with the ecological validity of real life. While the technological development steadily pushes towards even more realistic renderings of the real world— the elusiveness of social and emotional elements gradually becomes more evident. This is not the least true for behavioral studies in rich sociocul

Visualizing Light-Induced Microstrain and Phase Transition in Lead-Free Perovskites Using Time-Resolved X-Ray Diffraction

Metal halide perovskites have emerged as promising materials for optoelectronic applications in the last decade. A large amount of effort has been made to investigate the interplay between the crystalline lattice and photoexcited charge carriers as it is vital to their optoelectronic performance. Among them, ultrafast laser spectroscopy has been intensively utilized to explore the charge carrier d

Incidence of melancholic depression by age of onset and gender in the Lundby population, 1947–1997

Whether melancholic depression is a distinct syndrome or not has long been debated. There are few studies providing information about the epidemiology of melancholic depression. In this study, we investigate the incidence rates, overall as well as by gender and age of onset of melancholic depression according to Taylor and Fink and corresponding DSM–IV disorders: major depressive disorder (MDD) wi

Adding Value through Cross-Border M&A: Evidence from the Netherlands

Purpose: The aim of this thesis is to research corporate geographic diversification to determine if cross-border M&A involving Dutch acquirers and a selection of countries are value-enhancing for Dutch acquirers. Moreover we will aim to identify variables which influence value-creation in Dutch cross-border M&A. Methodology: This paper applies a deductive approach using theories and previ

En skolas rykte - Innebörden av en varumärkesorientering i den svenska gymnasieskolan

Bakgrund: I en tid med hårdnande konkurrens, där utbudet ofta är större än efterfrågan, tvingas organisationer till effektivisering. Därav har vikten av att implementera ett starkt varumärke ökat, via denna kan kunden upplysas om produkt, kvalitet samt funktion. Efter den svenska skolreformen infördes, vilket innebar att skolväsendet öppnade upp sina portar för konkurrens, har betydelsen av varumä

Personal branding – möjlighet eller krav?

Sammanfattning Examenarbetets titel: Personal branding – möjlighet eller krav? Seminariedatum: 2015-01-15 Ämne/kurs: FEKH29 Företagsekonomi: Examensarbete i marknadsföring på kandidatnivå, 15 högskolepoäng Författare: Magnus Skog, Justus Jahja, Niran Ahmad Handledare: Jon Bertilsson Nyckelord: Sociala medier, varumärke, företagsledare, finansiellt resultat Syfte: Uppsatsens syfte är att i eAbstract Title: Personal branding – opportunity or necessity? Seminar date: 2015-01-15 Course: FEKH29 Business administration: Degree Project in Marketing, Undergraduate Level, 15 hp. Authors: Magnus Skog, Justus Jahja, Niran Ahmad Advisor: Jon Bertilsson Key words: Social media, brands, Ceo, financial result Objective: The objective of this thesis is to in an explorative approach obtain th

Tackling Violence Against Women through Human Rights Law-Inspired Approaches (With Observations from the Philippines).

Violence against women (“VAW”) is a global matter; and human rights law-inspired approaches, also universal in nature (it is argued), can be the missing link in tackling a global problem. In underlining the universal applicability of human rights standards, principles and norms; it is suggested that drawing inspiration from human rights-based approaches would contribute to implementation of holist