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We hypothesized that key signaling pathways of glioma genesis might enable the molecular classification of gliomas. Gene coexpression modules around epidermal growth factor receptor (EGFR) (EM, 29 genes) or platelet derived growth factor receptor A (PDGFRA) (PM, 40 genes) in gliomas were identified. Based on EM and PM expression signatures, nonnegative matrix factorization reproducibly clustered 1

It is shown that the ternary system heavy water-heptane-hexadecyl hexaethylene oxide (C16E6) has a stable bicontinuous microemulsion phase down to an exceptionally low concentration at the balanced temperature of 26.8 °C. It is further demonstrated that the ambient gravitational field has an influence on the observed phase equilibria for typical sample sizes (∼1 cm). Direct measurements using a nu

The bacterial spore, the hardiest known life form, can survive in a metabolically dormant state for many years and can withstand high temperatures, radiation, and toxic chemicals. The molecular basis of spore dormancy and resistance is not understood, but the physical state of water in the different spore compartments is thought to play a key role. To characterize this water in situ, we recorded t

Highly efficient washing and extraction of microbeads to decomplex analytes ranging from small peptides to large viruses was realised in a microscaled continuous flow format. The bead washing principle reported herein is based on acoustophoresis, i.e. the primary acoustic radiation force in an ultrasonic standing wave and laminar flow properties are utilised to translate bioanalytes trapped on fun

Honeybees are one of our most important insects, not only for their pollination services but also for their production of honey. Honey is the main food for honeybees, produced from collected nectars and transported to the hive. Humans have consumed this mysterious food and applied it since ancient times in traditional medicine around the world. In 2005 we discovered an unknown key to honeybees’ he

Basic materials are traded globally and responsible for roughly 22 % of global carbon emissions. It is technically possible for the energy intensive industries (EIIs) that produce these materials to reach zero emission, but at a cost. So far, the fear of carbon leakage has been a barrier for implementing ambitious domestic climate policies that targets theses globally traded commodities. The intro

How should democratic states approach and respond to secessionist movements using tactics contrary to the constitution to achieve their goals? What is the role of international human rights mechanisms in these processes? This article sheds light on these questions by examining how the UN Human Rights Committee approached and assessed two complaints that came before it in the wake of the Catalan De

This chapter presents and discusses the main findings and conclusions of the volume and puts them into a broader perspective. Taken together, the different chapters contribute to closing the gap between historical studies based on parish records and contemporary research based on full-count registers or detailed surveys. The volume thereby fleshes out the narrative of twentieth-century demographic

This paper reframes our understanding of the discourse on work-life balance (WLB) from a global perspective, where life on the four income levels (from bottom of the wealth to top of the wealth) is equally considered. Based on a systematic literature review, our initial insights are that WLB of workers in the highest economic sectors has received significant attention from scholars and practitione

Objective: To study the efficacy of psoralen with ultraviolet A photochemotherapy (PUVA) and narrowband ultraviolet B phototherapy (NBUVB), for early-stage mycosis fungoides (MF) in Thais. Materials and Methods: A retrospective medical chart review of 50 cases was performed. Demographic data, type of phototherapy, duration of treatments, clinical response, relapse, and adverse effects were analyze

Jordan has one of the lowest available water supplies in the world; meanwhile Jordan has seen large increase in population and refugee’s fluxes, leading to an increase in water demand [1]. To address this unprecedented water scarcity, Jordan’s water must be used where its social and economic value is highest. Jordan must treat and reuse virtually every drop of water. It is expected to have more th

Primary central nervous system lymphoma (PCNSL), glioblastoma multiforme (GBM) and metastases may be difficult to differentiate based on conventional imaging alone. The aim of this study was to investigate the value of perfusion weighted imaging (PWI) in differentiating homogeneously enhancing PCNSL from homogeneously enhancing GBM and metastases. Seven consecutive patients presenting with homogen