Search results

Axonal conduction velocity, which ensures efficient function of the brain network, is related to axon diameter. Noninvasive, in vivo axon diameter estimates can be made with diffusion magnetic resonance imaging, but the technique requires three-dimensional (3D) validation. Here, high-resolution, 3D synchrotron X-ray nano-holotomography images of white matter samples from the corpus callosum of a m

Within cognitive science, “blindness” to choice is commonly treated as typical of human cognition, implying unreliable agents who essentially lack any awareness of their own choices (e.g. Johansson et al., 2005, 2008; Hall et al., 2010, 2013). Within cognitive semiotics, however, choice awareness is seen as a continuous phenomenon, which is susceptible to the influence of a variety of factors. Man

Three decades ago, systematic research on possible acute and long-term aftereffects of peritraumatic dissociation (PD) was partly spurred by the proposal of a Brief Reactive Dissociative Disorder (BRDD) and the associated literature reviews and analyses of datasets (Cardeña, Lewis-Fernández, Beahr, Pakianathan & Spiegel, 1996; Cardeña et al., 1998; Spiegel & Cardeña, 1991). The goal was to

The Paleogene history of biogenic opal accumulation in the North Atlantic provides insight into both the evolution of deepwater circulation in the Atlantic basin and weathering responses to major climate shifts. However, existing records are compromised by low temporal resolution and/or stratigraphic discontinuities. In order to address this problem, we present a multi-site, high-resolution record

During the Christianization of the early Slavic realms at the turn of the tenth century, a specific type of noble passion-bearing saint came about. Four saints were promoted in short succession in the western, north-eastern, and south-eastern Slavic realms in the span of less than a hundred years. All four were promoted as noble passion-bearing saints and prototypes of the good Christian ruler. Th

Human malignant hematopoietic stem and progenitor cells (HSPCs) reside in bone marrow (BM) niches, which remain challenging to explore due to limited in vivo accessibility and constraints with humanized animal models. Several in vitro systems have been established to culture patient-derived HSPCs in specific microenvironments, but they do not fully recapitulate the complex features of native bone

Purpose Cutaneous adverse drug reactions (cADRs) are a major cause of lamotrigine (LTG) discontinuation. Remarkable variation in their reported incidence suggests confounders and diverse terms and definitions. The aim of this study was to identify immunological cADRs and to throw light on classification and differential diagnoses in children and adults. Methods Hospital records of 2683 patients wi

Antibodies are central to acquired immunity against malaria. Plasmodium falciparum elicits antibody responses against many of its protein components, but there is also formation of antibodies against different parts of the red blood cells, in which the parasites spend most of their time. In the absence of a decisive intervention such as a vaccine, people living in malaria endemic regions largely d

Numerous studies have reported a positive association between ambient fine particles and daily mortality, but little is known about the particle properties or environmental factors that may contribute to these effects. This study assessed potential modification of radon on PM2.5 (particulate matter with an aerodynamic diameter <2.5 ?m)-associated daily mortality in 108 U.S. cities using a two-stag

We build a model to predict from first principles the properties of major mergers. We predict these from the coalescence of peaks and saddle points in the vicinity of a given larger peak, as one increases the smoothing scale in the initial linear density field as a proxy for cosmic time. To refine our results, we also ensure, using a suite of ∼400 power-law Gaussian random fields smoothed at ∼30 d

This chapter shows that marital status has had a fairly consistent association with mortality over the entire twentieth century for men. Increasingly, this association was also found among women. Married men have a survival premium today, and the same was true in the past. For men, marriage has been associated with lower mortality throughout the twentieth century and into the twenty-first century,

This study investigates speech production under various room acoustic conditions in virtual environments, by comparing vocal behavior and the subjective experience of speaking in four real rooms and their audio-visual virtual replicas. Sex differences were explored. Males and females (N = 13) adjusted their voice levels similarly to room acoustic changes in the real rooms, but only males did so in

Near-haploidization, that is, loss of one copy of most chromosomes, is a relatively rare phenomenon in most tumors, but is enriched among certain soft tissue sarcomas, including undifferentiated pleomorphic sarcoma (UPS). Presumably, near-haploidization can arise through many mechanisms. This study aimed to identify gene rearrangements that could cause near-haploidization. We here present two UPS

The pHrodo with an “off–on” response to the changes of pH has been widely used as a fluorescent pH probe for bioimaging. The fluorescence off–on mechanism is fundamentally important for its application and further development. Herein, the sensing mechanism, especially the relevant excited-state dynamics, of pHrodo is investigated by steady-state and time-resolved spectroscopy as well as quant

The ionizable-lipid component of RNA-containing nanoparticles controls the pH-dependent behavior necessary for an efficient delivery of the cargo - the so-called endosomal escape. However, it is still an empirical exercise to identify optimally performing lipids. Here, we study two well-known ionizable lipids, DLin-MC3-DMA and DLin-DMA using a combination of experiments, multiscale computer simula