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Despite the plethora of information on (S)-selective amine transaminases, the (R)-selective ones are still not well-studied; only a few structures are known to date, and their substrate scope is limited, apart from a few stellar works in the field. Herein, the structure ofLuminiphilus syltensis(R)-selective amine transaminase is elucidated to facilitate engineering towards variants active on bulki
Aims: To evaluate the cost-effectiveness of bimekizumab, an inhibitor of IL-17F and IL-17A, against biologic and targeted synthetic disease-modifying antirheumatic drugs (DMARD) for psoriatic arthritis (PsA) from the Swedish healthcare system perspective. Materials and methods: A Markov model was developed to simulate the clinical pathway of biologic [b] DMARD-naïve or tumor necrosis factor inhibi
This paper examines European narratives regarding border externalisation within the context of the European Trust Fund for Africa (EUTF). It seeks to understand how the EU shapes its discourse on African migration, recommends solutions, and evaluates outcomes. As the latest and most comprehensive instrument for externalising migration management, the EUTF offers abundant source material to compreh
The current situation of Uyghurs in the Xinjiang Uyghur Autonomous Region (XUAR) is considered by many as one of the most pressing human rights violations of the last few decades. The Uyghurs, being an ethnic minority in China, are voiceless under the current political leadership, which suppresses anything deviating from the official course set up by the Party leaders in Beijing. The legal guarant
A search for events with a dark photon produced in association with a dark Higgs boson via rare decays of the standard model Z boson is presented, using 139 fb^{-1} of sqrt[s]=13 TeV proton-proton collision data recorded by the ATLAS detector at the Large Hadron Collider. The dark boson decays into a pair of dark photons, and at least two of the three dark photons must each decay into a pair of
A novel photoemission type of X-ray Beam Position Monitor (XBPM) for the 'white' undulator radiation is proposed. The XBPM employs beamline frontend fixed mask as a source of photocurrent signal. Signal spatial distribution and XBPM response were analyzed for various undulator radiation parameters.
The field of ultrafast science is dependent on either ultrashort laser pulse technology or ultrafast passive detection. While there exists a plethora of sub-picosecond laser pulse solutions, streak cameras are singular in providing sub-picosecond passive imaging capabilities. Therefore, their use in fields ranging from medicine to physics is prevalent. Streak cameras attain such temporal resolutio
Background: Levodopa–entacapone–carbidopa intestinal gel (LECIG) was introduced on the Swedish market in 2019. The therapy is aimed at patients with Parkinson's disease (PD) with fluctuations and dyskinesias. Long-term efficacy and safety data are lacking. Objective: To investigate the efficacy, tolerability, and safety of LECIG in regular clinical practice for Parkinson's disease in Sweden. Metho
Recent scholarship in critical intelligence studies emphasizes the role of informal actors in democratic oversight, encouraging increased attention to practices and struggles of accountability. Less probed are the fundamental conditions enabling the work of informal oversight actors, and current struggles over such conditions. This article turns to the case of Sweden, a top-ranking state in the pr
This conceptual article examines the relational dynamic between the research field focusing on the far right and those critical scholars that endeavour to undertake these studies. It is theoretically anchored in the field of political science scholarship that recognises the key role played by gender in understanding both the ideological underpinnings and the workings of various far-right entities
I exploit variation in the date of transition from analogue to digital television signal in the UK across more than 40,000 geographical units to investigate the causal impact of television on employment. Using an event study model, I find that the digital transition increases employment probabilities. The impact is driven by mothers, primarily through an increase in part-time employment. I also sh
Due to increasing plastic production, the continuous release of primary and secondary nanoplastic particles (NPs, <1 μm) has become an emerging contaminant in terrestrial environments. The fate and transport of NPs in subsurface environments remain poorly understood, largely due to the complex interplay of mineralogical, chemical, biological, and morphological heterogeneity. This study examines in
Aim: The aim of this study was to explore the role of managers and employees with an assigned responsibility (i.e. inspirers) when integrating recovery-enhancing activities into everyday work in a primary health care setting. Background: The possibility of recovery during the workday is essential for employee wellbeing. However, the literature on workplace interventions focusing on recovery is sca
However, it is not clear to what extent corresponding perceptual preferences for intonational deviations might rely on listeners’ instrumental expertise or such contextual aspects as the metrical placement of tones. We investigated higher-education music students’ perceptual preferences for melodic intonation of local leading tones in unaccompanied classical violin performances. Recordings of 12 e
