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Cortico-basal ganglia circuits are thought to play a crucial role in the selection and control of motor behaviors and have also been implicated in the processing of motivational content and in higher cognitive functions. During the last two decades, electrophysiological recordings in basal ganglia circuits have shown that several disease conditions are associated with specific changes in the tempo
Over the past decades, the field of in vivo magnetic resonance (MR) has built up an impressive repertoire of data acquisition and analysis technologies for anatomical, functional, physiological, and molecular imaging, the description of which requires many book volumes. As such it is impossible for a few authors to have an authoritative overview of the field and for a brief article to be inclusive
Aim: Attention-deficit/hyperactivity disorder (ADHD) is the most common diagnosis within child- and adolescent psychiatry. Waiting lists and delayed care are major issues. The aim was to evaluate if standardized care (SC) for assessment and treatment of uncomplicated ADHD would reduce resource utilization and increase satisfaction with preserved improvement within the first year of treatment. Meth
Tungsten (W) and niobium (Nb) belong to the refractory metal group and are used as alloying elements in steels and superalloys for high demand products. These metals are also used in a high purity single-phase state for products within nuclear, space, military and research facilities.In the current study, tool wear development and surface quality at different cutting conditions have been evaluated
Kunskapsintensiva företagstjänster (KIBS) har en nyckelroll i den ekonomiska utvecklingen. Deras konkurrenskraft och värdeskapande processer bygger på komplexa samarbetsrelationer med kunder och andra aktörer. Av den anledningen har forskningen konventionellt lyft fram att dessa företags konkurrenskraft är starkt beroende av geografisk närhet till stora klient- och arbetsmarknader liksom till avanKnowledge intensive business services (KIBS) play a key role in economic development. Due to the complex and collaborative nature of their value creation processes, it is conventionally argued that they depend strongly on physical proximity to large client-, and labour-markets, as well as on closeness to advanced knowledge infrastructures. This thesis partially questions such conventional assumpti
Acceptance and Commitment Therapy (ACT) has been widely tested for chronic pain, with demonstrated efficacy. Nevertheless, although there is meta-analytical evidence on the efficacy of face-to-face ACT, no reviews have been performed on online ACT in this population. The aim of this meta-analysis is to determine the efficacy of online ACT for adults with chronic pain, when compared with controls.
Transfusion of ABO major incompatible platelets (where the recipient has antibodies against the ABO group of the transfused platelets) has been shown to be associated with lower platelet count increments following transfusion [1], although this does not appear to translate to a difference in bleeding outcomes [2]. Transfusion of minor ABO incompatible platelets (where the suspending plasma of the
The eyelids are susceptible to a number of skin cancers which are challenging to excise radically without sacrificing excessive healthy tissue. The way in which a tumor is delineated preoperatively has not changed significantly over the past century. The aims of the work presented in this thesis were to investigate two novel non-invasive techniques for diagnosing and delineating skin tumors.Extend
Manufacturing is an industry in which the effects of globalization are obvious. Manufacturing costs are a key factor in this respect and affect, for example, decisions about offshoring, i.e., moving production abroad. If Sweden and other Western countries are to maintain large manufacturing sectors, they must be competitive, making cost one of the most critical parameters. The work presented here
Borderline Personality Disorder (BPD) has largely been associated with self-harm and chronic suicidality, despite the fact that these behaviours comprise only one diagnostic criterion. Treatments for self-harm are mostly indicated for individuals with BPD. Emerging literature suggests that youth with histories of depression are at risk of both self-harm and completed suicide. For individuals with
In a recent paper we presented a procedure for optimal analyticalcontrol of several deformable mirrors based on only the measured guidestar wavefronts. The expected performance was evaluated for variousguide star configurations using up to three deformable mirrors. Forsimplicity the guide stars were assumed to be infinitely distant. Inthis paper we address the effect of using laser guide stars in
Background: Alzheimer's disease (AD) is a neurodegenerative disorder caused by a complex interplay of various factors. However, a satisfactory cure for AD remains elusive. Pharmacological interventions based on drug targets are considered the most cost-effective therapeutic strategy. Therefore, it is paramount to search potential drug targets and drugs for AD. Objective: We aimed to provide novel
