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MicroRNAs (miRNAs) are small non-coding RNAs that post-transcriptionally regulate gene expression. There have been several reports of miRNA deregulation in prostate cancer and the biological evidence for an involvement of miRNAs in prostate tumorigenesis is increasing. In this study, we show that miR-34c is downregulated in prostate cancer (p = 0.0005) by performing qRT-PCR on 49 TURPs from prosta
Diamond-Blackfan anemia (DBA) is a congenital erythroid hypoplasia caused by haploinsufficiency of genes encoding ribosomal proteins (RPs). Perturbed ribosome biogenesis in DBA has been shown to induce a p53-mediated ribosomal stress response. However, the mechanisms of p53 activation and its relevance for the erythroid defect remain elusive. Previous studies have indicated that activation of p53
The transcription factor STAT3 is constitutively active in several malignancies including castration-resistant prostate cancer and has been identified as a promising therapeutic target. The fungal metabolite galiellalactone, a STAT3 signaling inhibitor, inhibits the growth, both in vitro and in vivo, of prostate cancer cells expressing active STAT3 and induces apoptosis of prostate cancer stem cel
Cyclodextrin glycosyltransferases (CGTases) from Paenibacillus macerans, Thermoanaerobacter sp. ATCC 53627, Bacillus stearothermophilus and a Carboxydocella sp. (phylogenetically identified from genomic DNA) were characterized with respect to their catalytic activity in different reactions, with emphasis on reactions useful for the elongation of the carbohydrate group of alkyl glycosides. All CGTa
Variation in transcription factor 7-like 2 (TCF7L2), the strongest genetic risk factor for type 2 diabetes (T2D), may play a role in prostate cancer (PCa) depending on lifestyle factors. The aims of this study were to determine if TCF7L2 rs7903146 is associated with risk of PCa and if the association is modified by lifestyle factors independently of T2D status.
Architects have a key role to play when it comes to the design of future low-energy (solar) buildings. Proper design tools and working methods could help architects in the design process. In order to identify barriers of existing tools and methods for solar design, needs of architects for improved tools, and to gain an insight into architects’ methods of working during the design process, an inter
The antibody microarrays have become widespread, but their use for quantitative analyses in clinical samples has not yet been established. We investigated an immunoassay based on nanoporous silicon antibody microarrays for quantification of total prostate-specific-antigen (PSA) in 80 clinical plasma samples, and provide quantitative data from a duplex microarray assay that simultaneously quantifie
Human tumors xenografted in immunodeficient mice are crucial models in nuclear medicine to evaluate the effectiveness of candidate diagnostic and therapeutic compounds. However, little attention has been focused on the biological profile of the host model and its potential effects on the bio-distribution and tumor targeting of the tracer compound under study. We specifically investigated the dissi
Previous studies of prostate cancer (PCa) risk and anthropometrics (ie, body measurements) were based on single measurements or obtained over limited time spans.
Prostate specific antigen (PSA) is a well-established tumor marker, which is frequently employed as model biomarker to develop and evaluate emerging quantitative proteomics techniques, partially due to wide access to commercialized immunoassays serving as "gold standard". We designed a multiple reaction monitoring (MRM) assay to detect PSA proteoforms in clinical samples (n=72), utilizing specific
Background and Purpose The interaction between patient and physiotherapist (PT) is central in physiotherapeutic treatment. The purpose of this study was to investigate expert physiotherapists' perception of important factors influencing the quality of the interaction in physiotherapeutic treatment. Method Ten experienced PTs working in primary healthcare were interviewed twice, triangulating a so
Chemo-enzymatic epoxidation of oleic acid (OA) and its methyl ester has been performed using hydrogen peroxide and immobilized lipase from Candida antarctica (Novozym(R) 435). The purpose of the study was to characterize the reaction under solvent-free conditions. The reaction temperature had a significant impact on epoxidation of OA. At lower temperatures, the substrate conversion was hindered by
Wave cycles, i.e. pairs of local maxima and minima, play an important role in many engineering fields. Many cycle definitions are used for specific purposes, such as crest-trough cycles in wave studies in ocean engineering and rainflow cycles for fatigue life prediction in mechanical engineering. The simplest cycle, that of a pair of local maximum and the following local minimum is also of interes
Innovation policy makers of today are facing a range of challenges to solve, extending far beyond the usual paradigm of economic growth. This places a renewed pressure for more innovation within innovation policy itself. Our research theme aims to study the changing landscape for policy making and develop new approaches to guide the 21st century innovation policy.We have identified three trends in
https://www.circle.lu.se/new-perspectives-innovation-policy - 2026-05-07
Varför vill alla kula, även när det inte finns några kor att ropa på? Och får vilken söderkis som helst skriva en Värmlandspolska? Dessa frågor och många mer tar folkmusikern Molly Andersson sig an i Körcentrum Syds podd Det kommer inga kor! Säsong 1 Avsnitt 1: Sången I första avsnittet diskuteras hur man använder rösten när man sjunger folkmusik och kör. Vilka utmaningar står man inför som körs
https://www.korcentrumsyd.lu.se/samverkan/det-kommer-inga-kor - 2026-05-07
Viktig information inför terminsstarten Välkommen till Rättssociologiska institutionen! Denna information riktar sig till dig som har blivit antagen hos oss till fristående kurs eller kurs inom Kandidatprogrammet i kriminologi vårterminen 2026. Sidans innehållAllmän information för vårterminen 2026Viktiga datumScheman, litteraturlistor och kursplanerVälkomstbrevDetta behöver du göra som ny student
https://www.soclaw.lu.se/utbildning/studieinformation/valkommen-som-student-varen-2026 - 2026-05-07
KONSTNÄRLIGT MASTERPROGRAM I MUSIK • 120 HP • 2 ÅR Hållpunkter för din ansökan Ansök till programmet på antagning.seAnsökningsperiod: 1 december 2025 – 15 januari 2026 Styrk din behörighet. Sista kompletteringsdag för att styrka din behörighet är 26 januari 2026. Delprov 1. Ladda upp dina arbetsprover senast 21 januari 2026. En jury bedömer arbetsproverna och godkända sökande går vidare till delpr
