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Key points IL1RAP is overexpressed on candidate AML stem cells and is a promising target for antibody-based therapy.

Aortic stenosis (AS) shares risk factors with atherosclerotic vascular disease. Carotid intima-media thickness (IMT) and plaque may reflect the cumulative damage from exposure to different atherosclerotic risk factors. We examined the relationship of carotid IMT and plaque with incident AS in a prospective population-based study.

Statistical inference for extremes has been a subject of intensive research over the past couple of decades. One approach is based on modelling exceedances of a random variable over a high threshold with the generalized Pareto (GP) distribution. This has proved to be an important way to apply extreme value theory in practice and is widely used. We introduce a multivariate analogue of the GP distri

Letters and notes that expose collaboration in and between different creative networks and ethical-political theorists, governmental counsellors and personalities from 1886 to 1928 are now more accessible in the Anna Bugge Wicksell collection at the University Library of Lund. Anna Bugge Wicksell had central functions in The Neutral Conference for Continuous Mediation, after which she was co-opted

Methods of avoiding common problems associated with operator work in automated process control, such as understimulation and difficulties in achieving and maintaining necessary skills and competence, are addressed in this paper. The source of these problems is deduced here to be that monitoring tasks are a predominant part of the job. This case study shows how work in a highly automated process ca

Occlusion is the most common reason for lowered recognition yield in free-flow license-plate reading systems. (Non-)occluded characters can readily be learned in separate neural networks but not together. Even a small proportion of occluded characters in the training set will already significantly reduce the overall recognition yield. This paper shows that a modular network can handle a realistic

This dissertation is about bridging the gap between strategy and operations in organizations. To bridge that gap, processes are viewed not only from an operational perspective but also from conceptual, as well as a hierarchical perspectives. Bridging the gap can furthermore make organizational change initiatives more logical, and simplify the development and usage of needed performance measurement

The E4SD (Energy for Sustainable Development) Online Course is a joint initiative led by the International Institute for Industrial Environmental Economics (IIIEE) at Lund University, Sweden with the United Nations Development Programme (UNDP), the United Nations Environment Programme (UNEP), and the Global Network on Energy for Sustainable Development (GNESD) as partners. The overall objective of

Background: Aortic stenosis (AS) is the most common valvular heart disease in developed countries, confers high mortality in advanced cases, but can effectively be reversed using endovascular or open-heart surgery. We evaluated the association between AS and neighborhood socioeconomic status (NSES). Methods: We used Swedish population-based nationwide registers and an echocardiography screening co

One of the most frequently mutated proteins in human B-lineage leukemia is the transcription factor PAX5. These mutations often result in partial rather than complete loss of function of the transcription factor. While the functional dose of PAX5 has a clear connection to human malignancy, there is limited evidence for that heterozygote loss of PAX5 have a dramatic effect on the development and fu

The aim of this study was to investigate how solar drying setup and choice of juice pretreatment determine the drying flux in a fruit juice concentration process called solar assisted pervaporation. With this process, hygienic membrane pouches and solar energy are used to concentrate and preserve fruit juices. In this study, the feasibility of concentrating citrus (tangerine) juice into marmalade

Faithful modeling of tissues and organs requires the development of systems reflecting their dynamic 3D cellular architecture and organization. Current technologies suffer from a lack of design flexibility and complex prototyping, preventing their broad adoption by the scientific community. To make 3D cell culture more available and adaptable we here describe the use of the fused deposition modeli

Background: Global transcriptional profiling of individual cells represents a powerful approach to systematically survey contributions from cell-specific molecular phenotypes to human disease states but requires tissue-specific protocols. Here we sought to comprehensively evaluate protocols for single cell isolation and transcriptional profiling from heart tissue, focusing particularly on frozen t

BACKGROUND AND OBJECTIVES: Atrial fibrillation (AF) is associated with inflammation systemically and in the atrial tissue. Oxidized low-density lipoprotein (LDL) is increased in patients with AF and is suggested to be one of the molecules that drives inflammation. Autoantibodies against oxidized LDL and apolipoprotein B100, the protein component of LDL, are linked to atherosclerotic disease. Howev

The ability to capture alterations in the genome or transcriptome by next-generation sequencing has provided critical insight into molecular changes and programs underlying cancer biology. With the rapid technological development in single-cell sequencing, it has become possible to study individual cells at the transcriptional, genetic, epigenetic, and protein level. Using single-cell analysis, an

History shows that companies that survive in a severe competitive climate are those that are highly adaptable to market and technological changes. Product development is one of the key activities that assure company survival by renewal of its offer to its customers. A scientific formalism has to be created to fulfill two purposes: 1) to ensure that the design and development of a product is succes

The number of patients affected by Alzheimer's disease among the population is currently growing, while the availability of resources for their assistance is decreasing. A solution for this problem is provided by the use of Ambient Assisted Living technologies, with the objectives to prolong the independent living of patients at home, to relieve assistance burden on caregivers, and to improve care