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Mitochondrial permeability transition (MPT) is induced in isolated brain mitochondria by calcium and oxidants and is inhibited by adenine nucleotides. When induced, MPT is associated with equilibration of solutes of <1500 Da across the inner mitochondrial membrane. A persistent induction of MPT depolarizes the inner membrane and causes cessation of ATP synthesis, swelling of the matrix, and bursti
This doctoral thesis has its theoretical origin in the notion that the information flow between management teams, financial analysts and investors is especially exposed to information asymmetry when knowledge-intense companies are concerned. Information asymmetry may aggravate agency problems and risk causing an impairment of the efficient allocation of capital on the stock market. Therefore, the
Background: The Clubfoot Assessment Protocol (CAP)is a multi dimensional instrument designed for longitudinal follow up of the clubfoot deformity during growth. Item reliability has shown to be sufficient. In this article the CAP's validity and responsiveness is studied using the Dimeglio classification scoring as a gold standard. Methods: Thirty-two children with 45 congenital c
This article analyses the doctrine of free will (autexousion) in the confessions of St. Peter Mogila and Dositheos II Notaras of Jerusalem. Free will is a central concept in Eastern Christian anthropology and these two monuments of theology represent how the understanding of the concept of free will developed in Eastern Orthodox theology in the context of the confrontation with Western theologies
Popular Abstract in Swedish I hjärnan finns ett fantastiskt effektivt kontrollsystem för utförandet av olika typer av rörelser. Lillhjärnan är en viktig del av detta kontrollsystem eftersom skador på lillhjärnan kan leda till att fint styrda rörelser blir svårare eller kanske helt omöjliga att utföra. En förståelse av lillhjärnans funktion kan därför leda till en bättre generell förståelse av hur A modular organization has recently been described for the cerebellar control system comprising the forelimb areas of the C1/C3/Y zones in the cerebellar cortex and nucleus interpositus anterior (NIA) of the cat. A module is a group of cells in NIA which receives homogenous climbing fibre input via Purkinje cells that belong to the same set of microzones in the C1/C3/Y zones. The organization of i
Popular Abstract in Swedish Jorden är ett ytterst komplext och dynamiskt system. Livet har format planeten och utvecklats i takt med förändrade livsvillkor. Ekosystemen kontrolleras i hög grad av klimatet. Snabbt förändrade villkor innebär betydande påfrestningar för åtskilliga arter och ekosystem, inklusive planetens mest dominerande art, människan. Avhandlingens huvudfokus är att undersöka samsThe Earth is a highly complex and dynamic system. Life has shaped the entire planet and evolved in response to living conditions. Ecosystems are heavily affected by climate. Rapidly changing conditions imply considerable stress on several species and ecosystems, as well as to the most dominant species on the planet. The main focus of this thesis is to investigate climate and anthropogenic interac
Recently two new classes of low-rate codes have been presented. The first class is the super-orthogonal turbo codes (SOTCs) and the second is the maximum free distance (MFD) convolutional codes. In this paper we present an evaluation of the performance vs. arithmetic decoding complexity for these codes and compare them with the previously reported super-orthogonal convolutional codes (SOCCs). For
In this paper it is shown how a convolutional code can be used either to detect errors or to correct erasures. The erasure correction is related to the error detection. Using the active burst distance lower bounds on the error and erasure correction as well as error detection are obtained for convolutional codes.
Popular Abstract in Swedish Under 1980-talet blev riskerna med blodtransfusioner alltmer uppenbara. Störst uppmärksamhet väckte ett antal fall med spridning av HIV- (AIDS) smitta, men ännu vanligare var spridning av ett virus som kunde orsaka leverinflammation. Dessa risker är numera nästan helt försvunna men dels kvarstår en oro för spridning av nya, okända virus, dels har det visat sig att blodtBlood loss in major arthroplasty may be abundant and often necessitates blood transfusions. These may transmit disease and entail an immunological burden to the recipient. After trauma and surgery, the fibrinolytic system reacts with a short period of increased activity, followed by a fibrinolytic shut-down. In this thesis we investigated the impact of the early fibrinolytic activation on blood
The purpose of this paper is to demonstrate the close interaction between epistemic and evidential stance verbs on the one hand and social hierarchy and power on the other. It is hypothesized that there is a correlation between the degree and intensity of stance verbs and the social context in which they are generated. The data for the study comes from an online bulletin board, in which members ar
This thesis concerns the prediction of the fluid mechanical conditions in some specific large vessels in the human body. Large vessels are special in the way that the Reynolds number is relatively high and in the case of arteries the flow is pulsatile. The aim is to contribute to the knowledge of flow patterns in large vessels, and ways to predict and measure fluid mechanical parameters such as sh
In summer 1987 most of the multibody dynamics community met at the JPL, Pasadena, to discuss the needs and the open problems in multibody system simulation, especially for space applications. P. W. Likins stated in his survey [16]: “Computational questions focused initially on the selection of subroutines for numerical integration, matrix inversion, or eigensystem analysis,and lately have shifted
Popular Abstract in Swedish Enterostatin är en peptid (en liten del av ett protein) som bildas i magsäcken och tarmen under en måltid. I djurförsök då råttor behandlas med enterostatin har man funnit att både aptiten och kroppsvikten minskade. Den minskade aptiten gällde speciellt för fett. Enterostatin fungerar som en mättnadssignal för fett och kan därför vara viktig för att hindra uppkomsten avThe presence of procolipase and enterostatin in the rat gastrointestinal tract has been investigated. Procolipase was identified, using in situ hybridization and immunohistochemistry, in exocrine cells of the pancreas as well as in chief cells of the fundus region of the stomach. Enterostatin is the activation peptide of procolipase and it has been found to act as a satiety signal for fat. Using a
The most common situation connection with freshwater production from sea water (desalination) is producing a brine waste stream, usually discharged back into sea water. The purpose of this study is to explore the behavior of a dense jet and bottom plume, composed of brine water of heavier effluent into a quiescent homogeneous ambient, discharged into a receiving body of lighter fresh water (tank).
