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District Heating is a cornerstone for the decarbonisation of the heating and cooling sector in Europe. Nonetheless, this technology is currently absent in a majority of the continent's urban areas, and hence the need for appropriate methods by which to estimate the cost, as well as underlying cost parameters, to assess the feasibility of developing district heating networks is of general interest.
INTRODUCTION: Recent clinical trials of amyloid beta (Aβ)-targeting therapies in Alzheimer's disease (AD) have demonstrated a clinical benefit over 18 months, but their long-term impact on disease trajectory is not yet understood. We propose a framework for evaluating realistic long-term scenarios. METHODS: Results from recent phase 3 trials of Aβ-targeting antibodies were integrated with an estim
Aim: To audit adherence to the Swedish paediatric guidelines for urinary tract infections (UTIs) in infants. Secondary objectives were to compare findings on imaging performed according to the guidelines with imaging without guideline support and to identify predictors of non-adherence. Methods: A prospective multicentre study of infants <1 year treated at paediatric hospitals for their first UTI.
Ecocriticism tends to acknowledge anthropomorphisms as a possible tool to create empathy for nonhumans, but in doing so mostly labels said tool as too sentimental for serious environmental literature. This paper aims to establish a categorisation of anthropomorphisms in media that allows a more diverse and detailed analysis of humanised nonhumans. It seeks to overcome the prevailing idea that anth
Let f be a holomorphic self-map of the unit disc. We show that if log(1 − | f (z)|) is integrable on a sub-arc of the unit circle, I , then the set of points where the function f has finite Carathéodory angular derivative on I is a countable union of Beurling–Carleson sets of finite entropy. Conversely, given a countable union of Beurling–Carleson sets, E , we construct a holomorphic self-map of t
This work presents a statistical approach for estimating and analyzing the downward transport pattern and distribution of soil water by the use of pattern analysis of space-time correlation structures. This approach, called the Space-time Correlation Field, is mainly based on the analyses of correlation functions simultaneously in the space and time domain.The overall purpose of this work is to de
This Letter introduces a novel, to the best of our knowledge, method for assessing fruit quality using white-light biospeckle displacement analysis. The primary aim is to demonstrate that speckle displacement behavior differs between healthy and decaying regions, offering a unique means of gauging bioactivity levels, a feature that has not been explored in previous biospeckle research. By examinin
Sustainable access to effective antibiotics is a main rationale for addressing antimicrobial resistance, for calls to enhance antibiotic supply security and for development support to promote health system capacity in low- and middle-income settings. Standard models for valuing pharmaceuticals fail to capture the full value of sustainable access to effective antibiotics. In effect, assessments of
BACKGROUND AND PURPOSE: Developmental dysplasia of the hip (DDH) affects around 1.5% of newborns in Sweden with few late detected cases (0.12 per 10,000). The most common treatment for DDH in Sweden is with the von Rosen splint, with radiographs at 3 and 12 months of age. Little is known about the remodeling of acetabular dysplasia following treatment initiated in the neonatal period. We aimed to
The Dirichlet–Neumann alternating method is a common domain decomposition method for nonoverlapping domain decompositions without cross-points, and the method has been studied extensively for linear elliptic equations. However, for nonlinear elliptic equations, there are only convergence results for some specific cases in one spatial dimension. The aim of this manuscript is therefore to prove that
Mobility is essential to our modern world to move people and goods. However, mobility has also its downside as transport sectors are substantial emitters of greenhouse gases and air pollutants. Increasingly energy efficient combustion engines and turbines, as well as electrification and carbon-neutral fuels, will reduce the climate impacts of transportation. When such technologies are combined wit
Drawing on Markus and Nurius’s (1986) theory of possible selves and Higgins’s (1987) theory of self-discrepancies, Dörnyei (2005, 2009) developed the L2 self-guide, a construct explaining the generation of motivation for language learning. Because Dörnyei focused on convergences in the source theories, L2MSS researchers have come to regard possible selves (Markus & Nurius, 1986) and self-guide
Physical exercise can play an important role both in primary and secondary cardiovascular disease prevention by virtue of its multisystem effects. These beneficial adaptations at the whole-body level include improvements in mitochondrial health, vascular function, and autonomic balance, together with attenuation of inflammation and the release of ‘exerkines’ with pleiotropic effects. Thus, several
The ESS linac is under construction by the ESS partner institutes (socalled In-Kind Contributors - IKC) and will operate the most powerful proton beam ever for neutron spallation source. The linac delivers 5 MW via 2 GeV protons at a repetition rate of 14 Hz at the He-cooled solid tungsten target. The pulsed neutrons, result of the spallation, will reach the science instruments after having been m
Biocatalysis has emerged as a cornerstone of sustainable manufacturing, yet conventional modes are hindered by inherent limitations such as metabolic interference, mass transfer barriers, and instability. This study presented a novel platform using fragmented Gluconobacter oxydans, combining the autonomous cofactor regeneration of whole cells with the superior substrate accessibility of free enzym
Bark beetle species of the genera Ips and Dendroctonus represent a threat to forests in both North America and Europe. Under normal circumstances, these beetles recycle dying trees into nutrients, but under certain conditions, growing populations can overcome healthy tree defenses and cause severe economic loss in forestry. The most economically relevant bark beetle species communicate with aggreg
The high neutron flux of the European Spallation Source in Lund, Sweden, opens new possibilities for neutron protein crystallography. Making full use of these gains requires dedicated instrumentation and support facilities to maximize its contribution to our understanding of biological processes at the molecular level.
Objective To delineate organ-specific and systemic drivers of metabolic dysfunction-associated steatotic liver disease (MASLD), we applied integrative causal inference across clinical, imaging, and proteomic domains in individuals with and without type 2 diabetes (T2D). Methods Bayesian network analyses and complementary two-sample Mendelian randomization were used to quantify causal pathways link
