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Over the last few decades, a critical revision of prior scholarship concerning Roman domestic space has led to the reappraisal of the traditional account of the atrium suggesting a possibility for this space to be ‘unroofed’. Accordingly, scholars have proposed to look for a convergence of impulses previously cultivated in isolation combining new theoretical frameworks, and a careful examination o
Growing preclinical and clinical evidence highlights neurosteroid pathway imbalances in Parkinson's Disease (PD) and L-DOPA-induced dyskinesias (LIDs). We recently reported that 5α-reductase (5AR) inhibitors dampen dyskinesias in parkinsonian rats; however, unraveling which specific neurosteroid mediates this effect is critical to optimize a targeted therapy. Among the 5AR-related neurosteroids, s
Allergen specific immunotherapy (AIT) is the only causal therapeutic option for allergic airway diseases including asthma and allergic rhinitis. AIT has been shown to restore the allergen immune tolerance, can modify both the early and late-onset allergen-specific airway hyperreactivity, helps to achieve disease control/remission and prevents new sensitisations. Recent real life data on long-term
När vi människor försöker röra på oss skickas elektriska impulser genom nervsystemet från hjärnan ner till de muskler som är inblandade i den tilltänkta rörelsen. Att kunna mäta sådana nervimpulser hade varit av värde för en rad tillämpningar—information hade då kunnat överföras direkt från nervsystemet utan att gå via långsamma, mekaniska gränssnitt så som tangentbord och pekskärmar. Olyckligtvis
Explaining the maintenance of genetic variation in fitness-related traits within populations is a fundamental challenge in ecology and evolutionary biology. Frequency-dependent selection (FDS) is one mechanism that can maintain such variation, especially when selection favours rare variants (negative FDS). However, our general knowledge about the occurrence of FDS, its strength and direction remai
Blog for the European Network on Statelessness on the impact of the temporary asylum law on the resolution of statelessness of refugees.
Let f be a holomorphic self-map of the unit disc. We show that if log(1−|f(z)|) is integrable on a sub-arc of the unit circle, I, then the set of Carathéodory angular derivatives of f on I is a countable union of Beurling-Carleson sets of finite entropy. Conversely, given a countable union of Beurling-Carleson sets, E, we construct a holomorphic self-map of the unit disc, such that its set of Cara
Differential equations are an important building block for modeling processes in physics, biology, and social sciences. Usually, their exact solution is not known explicitly though. Therefore, numerical schemes to approximate the solution are of great importance. In this thesis, we consider the temporal approximation of nonlinear, nonautonomous evolution equations on a finite time horizon. We pres
District Heating is a cornerstone for the decarbonisation of the heating and cooling sector in Europe. Nonetheless, this technology is currently absent in a majority of the continent's urban areas, and hence the need for appropriate methods by which to estimate the cost, as well as underlying cost parameters, to assess the feasibility of developing district heating networks is of general interest.
INTRODUCTION: Recent clinical trials of amyloid beta (Aβ)-targeting therapies in Alzheimer's disease (AD) have demonstrated a clinical benefit over 18 months, but their long-term impact on disease trajectory is not yet understood. We propose a framework for evaluating realistic long-term scenarios. METHODS: Results from recent phase 3 trials of Aβ-targeting antibodies were integrated with an estim
Background:Support, Monitoring, and Reminder Technology for Mild Dementia (SMART4MD), a customized tablet app, was developed to improve or maintain the quality of life of people with mild cognitive impairment (MCI) and their informal caregivers.Objective:This study conducts an 18-month economic evaluation of the SMART4MD app, in addition to standard care, compared with standard care alone in Swede
The Internet is a large used technology and seniors, like everyone else, want to take part in the experience of navigate the Web. Many guidelines about how to develop usable web pages exist, but not many of them are focused on seniors. This paper aims to issue guidelines for developing web pages intended to be used by seniors, based upon the results of the observations of seniors and younger adult
This thesis is about returns to schooling for Mexican immigrants to the United States. The United States became the home of many immigrants. There is an evidence that large amount of immigrants in USA are from Mexico. They are among both oldest and newest inhabitants of the nation. Mexican immigrants and their descendants now make-up a significant portion of the US population and have become one o
In this paper we inquire into the relationships between the Greek myth of Phaeton and Volkswagen's project to produce a luxury car (named Phaeton). Volkswagen apparently felt that the lack of a luxury car opened the possibility to question their 'son-of-God status', just like Phaeton in the Greek story. This inquiry is contextualized in the emergence of a more and more direct art-management relati
The evolution of reading frame maintenance must have been an early event, and presumably preceded the emergence of the three domains Archaea, Bacteria and Eukarya. Features evolved early in reading frame maintenance may still exist in present-day organisms. We show that one such feature may be the modified nucleoside 1-methylguanosine (m(1)G37), which prevents frameshifting and is present adjacent
The recent commercialisation of the first disease-modifying drugs for Alzheimer's disease emphasises the need for consensus recommendations on the rational use of biomarkers to diagnose people with suspected neurocognitive disorders in memory clinics. Most available recommendations and guidelines are either disease-centred or biomarker-centred. A European multidisciplinary taskforce consisting of
In this talk recent progress in studying the short-distance properties of the hadronic light-by-light contribution to the muon g−2 is described. The intermediate and short-distance part contributes a large part of the error of the theoretical prediction as described in the white paper [1]. We showed that the massless quark-loop is the first term in a systematic expansion at short-distances, a resu
