Filetype
Mutational signatures are patterns of mutations that arise during tumorigenesis. We present an enhanced, practical framework for mutational signature analyses. Applying these methods to 3,107 whole-genome-sequenced (WGS) primary cancers of 21 organs reveals known signatures and nine previously undescribed rearrangement signatures. We highlight interorgan variability of signatures and present a way
Tungsten (W) and niobium (Nb) belong to the refractory metal group and are used as alloying elements in steels and superalloys for high demand products. These metals are also used in a high purity single-phase state for products within nuclear, space, military and research facilities.In the current study, tool wear development and surface quality at different cutting conditions have been evaluated
This chapter examines the aesthetic of the sinograph in the French-language novels, calligraphic works, and picture books by two first-generation Chinese migrant writers and artists in France, François Cheng and Shan Sa. It begins with an illustration of Cheng's and Shan's 'Chinese' calligraphic works (accompanied by the artists' French texts) (Et le Souffle devient signe: Portrait d’une âme à l’e
Kunskapsintensiva företagstjänster (KIBS) har en nyckelroll i den ekonomiska utvecklingen. Deras konkurrenskraft och värdeskapande processer bygger på komplexa samarbetsrelationer med kunder och andra aktörer. Av den anledningen har forskningen konventionellt lyft fram att dessa företags konkurrenskraft är starkt beroende av geografisk närhet till stora klient- och arbetsmarknader liksom till avanKnowledge intensive business services (KIBS) play a key role in economic development. Due to the complex and collaborative nature of their value creation processes, it is conventionally argued that they depend strongly on physical proximity to large client-, and labour-markets, as well as on closeness to advanced knowledge infrastructures. This thesis partially questions such conventional assumpti
Acceptance and Commitment Therapy (ACT) has been widely tested for chronic pain, with demonstrated efficacy. Nevertheless, although there is meta-analytical evidence on the efficacy of face-to-face ACT, no reviews have been performed on online ACT in this population. The aim of this meta-analysis is to determine the efficacy of online ACT for adults with chronic pain, when compared with controls.
Weaving and femininity are historically intimately connected with the concept of Fate. In antiquity Fate was portrayed as a powerful female principle controlling the cosmic system humans inhabited. However, as the antique religious world gave way to a new era, the role of Fate subsided under Christian dominance. This article examines how this change played out, and how the worldview that won promi
Transfusion of ABO major incompatible platelets (where the recipient has antibodies against the ABO group of the transfused platelets) has been shown to be associated with lower platelet count increments following transfusion [1], although this does not appear to translate to a difference in bleeding outcomes [2]. Transfusion of minor ABO incompatible platelets (where the suspending plasma of the
Research into repair within the circular economy (CE) typically focuses on technical aspects of design, policy, and markets, and often assumes or implies simplified conditions for the user/owner and the product-system to explain the barriers to scaling repair activities. By integrating life cycle and temporal dimensions (time-sequence) into a broad System of Repairability framework, we demonstrate
Ecodesign policy for energy-using products so far has tended to focus on the energy efficiency requirements, but there is increasing interest in durability requirements as well. This exploratory study analyses whether and when long lifetimes are preferable when considering the trade-offs between durability and other important parameters such as costs and environmental impacts, examining the case o
Autologous (auto-) or allogeneic (allo-) hematopoietic cell transplantation (HCT) are accepted treatment modalities for mantle cell lymphoma (MCL). Recently, chimeric antigen receptor (CAR) T-cell therapy received approval for MCL; however, its exact place and sequence in relation to HCT is unclear. The ASTCT, CIBMTR, and the EBMT, jointly convened an expert panel to formulate consensus recommenda
An indoor localization system for positioning evacuating people can be anticipated to increase the chances of a safe evacuation and effective rescue intervention in case of a tunnel fire. Such a system may utilize prevalent wireless technologies, e.g., Bluetooth, RFID and Wi-Fi, which today are used to survey incoming and outgoing traffic to a certain space or location, to estimate group sizes and
Cadmium (Cd) contamination and soil salinity are the main environmental issues reducing crop productivity. This study aimed to examine the combined effects of salinity (NaCl) and Cd on the physiological and biochemical attributes of quinoa (Chenopodium quinoa Willd.). For this purpose, 30-day-old plants of quinoa genotype “Puno” were transplanted in Hoagland's nutrient solution containing diverse
Background: While cognitive-behavioral therapy (CBT) is the gold-standard psychological treatment for major depression (MD), non-response and lacking stability of treatment gains are persistent issues. Potential factors influencing treatment outcome might be lifetime trauma history and possibly associated primarily prefrontal-cortex- and hippocampus-dependent cognitive alterations. Method: We inve
Capacity development —an integral part of development cooperation in general and for disaster risk reduction (DRR) in particular—has had limited success so far. This article investigates capacity development challenges and opportunities from the viewpoint of the staff of progressive governmental donor agencies. Data were obtained from 26 semi-structured interviews with informants from seven donor
Ability to efficiently localize productive foraging habitat is crucial for nesting success of insectivorous birds. Some bird species can use olfaction to identify caterpillar-infested trees by detection of herbivore induced plant volatiles (HIPVs), but these cues probably need to be learned. So far, we know very little about the process of olfactory learning in birds, whether insectivorous species
Colon capsule endoscopy as an alternative to colonoscopy for the diagnosis of colonic disease may serve as a less invasive and more tolerable investigation for patients. Our aim was to examine patient-reported outcomes for colon capsule endoscopy compared to conventional optical colonoscopy including preference of investigation modality, tolerability and adverse events. A systematic literature sea
Given population aging and the emphasis on in-home care, more working-age adults face demands of providing unpaid care to the elderly with potential implications for their wellbeing. Such effects likely vary across Europe because care is differently organized with more or less public support, dependence on family, and orientation toward gender equality. We studied the relationship between unpaid c
We use a unique source from the Swedish royal demesnes to examine the work and relative wages of women in sixteenth-century Sweden, an economic laggard in the early modern period. The source pertains to workers hired on yearly contracts, a type more representative of historical labour markets than day labour on large construction sites, and this allows us to observe directly the food consumed by w
