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Neurotensin is released from the gut after fat intake and has a role in appetite regulations. Proneurotensin is a stable fragment of the neurotensin precursor hormone and fasting plasma proneurotensin levels have shown to be significantly associated with the development of cardiovascular disease in middle aged participants of the Malmö Diet and Cancer Study. Here, we aimed at replicating the initi
Objective: To compare mortality risk over up to 14 years of follow-up in methotrexate-refractory patients with early RA randomized to a strategy starting with addition of infliximab vs addition of SSZ and HCQ. Methods: Data was from the two-arm, parallel, randomized, active-controlled, open-label Swefot trial in which patients with early RA (symptom duration <1 y) were recruited from 15 rheumatolo
The Unified Glare Rating (UGR) method defined by the International Commission on Illumination is practically the only one used for evaluation of discomfort glare in the lighting design process. However, it is unclear if this method aligns with subjective discomfort glare measures using subjective glare indexes (SGIs). We compared calculated UGR values with commonly used subjective discomfort glare
Background: White adipose tissue (WAT) dysfunction including an aberrant expression of miRNAs is strongly associated with the risk of developing type 2 diabetes (T2D), with limited evidence linking early changes in the WAT-derived miRNAs and T2D. The present study aims to identify early miRNome changes prognostic for T2D in mice and humans. Methods: Gonadal (g) WAT of diabetes-resistant and diabet
This chapter provides an overview of the different optical sectioning methods that enable performing three dimensional (3D) imaging of possibly complex samples. It discusses their benefits and limitations regarding their penetration depth, their imaging speed, their photo-toxic effect or their complexity. Focusing on fluorescence imaging, the chapter dives into approaches that make it possible to
Traffic-related air pollution has severe implications for our health and stringent emission legislation is being enforced to traffic emissions, for example in the EU, USA, and China. With stricter emission legislation (next is EURO 7) and a rapid growth of battery electrical vehicles (BEVs) the combustion-derived pollutants emitted from the tailpipe are decreasing. However, heavier vehicles have r
BACKGROUND: Global longitudinal strain (GLS) and left atrial strain metrics, including reservoir (LAr), contraction (LAct), and conduit strain (LAcd), have emerged as key indicators of left ventricular (LV) function and filling pressures. However, the prognostic value of these markers for risk stratification in acute heart failure (HF) remains uncertain, particularly in identifying patients at ele
Introduction: Sepsis, a widespread global ailment, involves an exaggerated immune response, leading to hyperinflammation and immunosuppression. Extracellular histones, released during hyperinflammation as part of the defensive response against pathogens, significantly contribute to sepsis pathogenesis, compromising viability of the host’s endothelial cells and contributing to organ failure. Method
Comparison of ROS production of individual particle components from traffic-related sources can inform new health policies and emissions legislation. This work aims to quantify acellular ROS production and oxidative potential (OP) of such individual particle components from combustion, brake, tire, and road wear. Particle characteristics are probed to identify source-specific markers and improve t
This master’s thesis explores the impact from the fire investigations by the Swedish Accident Investigation Authority (SHK) on fire safety in Sweden. Through a mapping survey and a qualitative interview study, it is found that it is often difficult to identify clear connections between the investigations’ safety recommendations and real improvements to fire safety, due to long time spans and multi
The gut microbiota is associated with human health and disease. Here we conducted a genome-wide association study of host genetic factors influencing gut microbiota composition in 12,652 individuals from the Trøndelag Health Study (HUNT), with replication in Nordic cohorts (n = 16,017–21,976). We identified 12 reproducible SNP–species associations across six genomic loci, including known (LCT, ABO
Background SLE is a systemic autoimmune disease with a large number of common risk gene variants, but several rare gene variants can cause monogenic SLE. The relationship between common and rare variants in SLE is unclear. We therefore investigated the occurrence of rare deleterious variants in patients with childhood-onset SLE (cSLE) and adult-onset SLE (aSLE) and compared the frequency of these
AIMS: A history of preeclampsia is associated with at least a twofold increased risk of coronary artery disease (CAD), with unclear underlying mechanisms. This study aimed to investigate coronary plaque characteristics in women with a history of preeclampsia compared to women from the general population.METHODS: In this cross-sectional study, women with a history of preeclampsia from the Cardiovas
This thesis investigates particle sorting in deterministic lateral displacement (DLD) microfluidic devices, with a focus on how particle size and shape influence sorting behavior. A broad range of synthetic and biological particles were studied, including polystyrene particles, fabricated silicon-based structures, and bacterial samples with diverse physical properties.While DLD has traditionally b
Disruptions in gut microbiome are implicated in cardiometabolic disorders and other health outcomes. Antibiotics are known gut microbiome disruptors, but their long-term consequences remain underexplored. Here we combined individual-level data from the Swedish Prescribed Drug Register with fecal metagenomes of 14,979 adults to examine the association between oral antibiotic use over 8 years and gu
Objective To compare longitudinal speech outcomes at ages 5 and 10 years in foreign-born and Swedish-born children with cleft palate with or without cleft lip (CP ± L), and assess impact of cleft type, additional diagnosed conditions, sex, and age at completed primary palatal surgery.DesignLongitudinal, registry-based cohort study.SettingRegional public care university hospitals in Sweden.Particip
The metastatic potential of cancer cells is closely linked to their mechanical properties, and changes in these properties often correspond to the progression of the disease. To study how mechanical factors such as cell size and deformability influence the spread of cancer and the surrounding extracellular matrix, it is crucial that cancer cell populations be sorted in relevant subpopulations with
