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Objectives: Systemic lupus erythematosus (SLE) is an autoimmune disease with extensive heterogeneity in disease presentation between patients, which is likely due to an underlying molecular diversity. Here, we aimed at elucidating the genetic aetiology of SLE from the immunity pathway level to the single variant level, and stratify patients with SLE into distinguishable molecular subgroups, which

Self-assembly of nanoparticles into vertical structures or larger ensembles can be a powerful method to achieve a strong collective behavior while still obtaining many of the same properties of the individual nanoparticles. In this study, we achieve directed self-assembly of magnetic nanoparticles into nanochains when depositing in a combined magnetic and electric field (M-ESP). We show that the C

Background: To understand how the neuronal circuits in the brain process information there is a need for novelneuro-electronic interfaces that can interact chronically with brain tissue with minimal disturbance of thephysiological conditions in the tissue, in awake and freely moving animals. For this, there is a need for implantableneuro-electronic interfaces that are mechanically compliant with t

Background: Blood eosinophil count (BEC) and fractional exhaled nitric oxide (FeNO) concentration are established biomarkers in asthma, associated particularly with the risk of exacerbations. We evaluated the relationship of BEC and FeNO as complementary and independent biomarkers of severe asthma exacerbations. Methods: This observational study included data from the Optimum Patient Care Research

We will present the formation of nanoparticle chains by deposit magnetic iron oxide aerosol nanoparticles in a combined electric and magnetic field. Aerosol methods, in particular spark ablation, provides a good means to produce magnetic nanoparticles with a controllable size and concentration in a broad size range without agglomeration. These aerosol nanoparticles are usually deposited using an e

It was believed that Cdk2-cyclin E complexes are essential to drive cells through the G1-S phase transition. However, it was discovered recently that the mitotic kinase Cdk1 (Cdc2a) compensates for the loss of Cdk2. In the present study, we tested whether Cdk2 can compensate for the loss of Cdk1. We generated a knockin mouse in which the Cdk2 cDNA was knocked into the Cdk1 locus (Cdk1Cdk2KI). Subs

Background/objectives: Studies on the health effects of whole grains typically use self-reported intakes which are prone to large measurement errors. Dietary biomarkers that can provide an objective measure of intake are needed. New alkylresorcinol (AR) metabolites (3,5-dihydroxycinnamic acid (DHCA), 2-(3,5-dihydroxybenzamido)acetic acid (DHBA-glycine) and 5-(3,5-dihydroxyphenyl) pentanoic acid (D

Pilot-scale tests were run with ozonation for reduction of 24 pharmaceuticals at 10 full-scale wastewater treatment plants in southern Sweden. Reduction was evaluated based on doses of 3, 5 and 7 g O3/m3 at all plants. The reduction of pharmaceuticals reached on average 65% at 3 g O3/m3, 78% at 5 g O3/m3 and 88% for 7 g O3/m3 in terms of total concentration of pharmaceuticals. Specific ozone dose

In this study, I investigate what a figurative sense is in the Swedish Academy Dictionary (SAOB). The description of figurative senses in the dictionary is analyzed in terms of word classes and the use of specific labels in the definitions, such as bildl. (figurative), is mapped out. From a cognitive semantic perspective, I investigate what the figurative uses of the present cases consist of, in a

Background: The Self-Harm Antipathy Scale (SHAS) is a questionnaire designed to measure nurses’ attitudes towards self-harm. This can be useful to improve the quality of care provided to individuals who self-harm. Aim: The purpose of this study was to revise and adapt the SHAS for use in Sweden and evaluate the psychometric properties of this Swedish version (Self-Harm Antipathy Scale–Swedish Revi

Aim: To describe the experience of distress in people with cancer of working age. Design: A cross-sectional study. Methods: In this cross-sectional study, patients (N = 168) with both ongoing (N = 56) and completed treatment (N = 105) completed the Distress Thermometer and the detailed problem list. Data were analysed by descriptive and analytical statistics. Results: A large proportion of patient

Scope: Several dietary fiber properties are suggested to be important for the profiling of the microbiota composition, but those characteristics are rather unclear. Whether different physico-chemical properties of barley dietary fiber influence the gut microbiota composition is investigated. Methods and results: Seven diets containing equal amounts of dietary fiber from barley malts, brewer's spen

Background: Evidence from observational comparative effectiveness research (CER) is ranked below that from randomized controlled trials in traditional evidence hierarchies. However, asthma observational CER studies represent an important complementary evidence source answering different research questions and are particularly valuable in guiding clinical decision making in real-life patient and pr

Introduction: A Task Force was commissioned jointly by the European Academy of Allergy and Clinical Immunology (EAACI) and the Respiratory Effectiveness Group (REG) to develop a quality assessment tool for real-life observational research to identify high-quality real-life asthma studies that could be considered within future guideline development. Methods: The resulting REal Life EVidence Assessm

In this study, we developed a nanoparticle-based mesoporous composite that consisted of silicate-titanate nanotubes (STNTs) supported in hydrogel chitosan beads (STNTs-Ch beads) and was studied for Cd2+ adsorption. By using Fourier-transform infrared spectroscopy, transmission and scanning electron microscopy coupled to an energy-dispersive X-ray spectrometer, we coulddetermine that the hollow STN

Some light beams rotate as they propagate. If it is not the polarization vector, but the phase structure that rotates, the beam is said to carry orbital angular momentum (OAM). Such beams exhibit a helical phase front, where the phase rotates around a symmetry center. Because the phase in the center is undefined (and the intensity there is therefore zero), it is often termed a phase singularity or

The process of high-order harmonic generation requires laser intensities around 1014 W/cm2, most easily reached with laser pulses of high energy, thus implicitly limiting the repetition rate of attosecond sources. A route towards multi-MHz attosecond sources relies on HHG inside a passive enhancement cavity [1]. Although successfully demonstrated for attosecond pulse trains, the generation of sing

BACKGROUND AND AIM: Progression to fibrosis in non-alcoholic fatty liver disease (NAFLD) is associated with an increased risk of liver-related events, overall mortality and possibly metabolic comorbidities. Our aim was to determine if non-invasive fibrosis scoring systems can predict the future risk of diabetes mellitus, cardiovascular disease (CVD), chronic kidney disease (CKD), liver-related eve

Birds possess a magnetic sense and rely on the Earth's magnetic field for orientation during migration. However, the geomagnetic field can be altered by solar activity at relative unpredictable intervals. How birds cope with the temporal geomagnetic variations caused by solar storms during migration is still unclear. We addressed this question by reproducing the effect of a solar storm on the geom