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Mitochondrial replacement therapy has been developed in order to prevent the transmission of mitochondrial mutations, yet it raises ethical concerns, particularly regarding the involvement of third-party DNA and the risks associated with donor procedures. This paper explores an alternative approach using synthetic DNA (synDNA) to construct mitochondrial organelles, thereby bypassing the need for d

Virtual reality (VR) is a technology that offers near real-world experiences in various fields. With the widespread use of virtual environments designed to provide VR experiences, the amount of data collected from these environments has increased rapidly. However, as the volume of data grows, there is a need to develop analysis processes and advance the data-driven development model. In this study

Monitoring agricultural land with optical remote sensing offers a valuable tool for estimating crop yield and supporting decision-making for food security. Cropland phenology indicators, such as the start of season (SOS), the end of season (EOS), and the number of growing seasons per year, provide essential information for land managers. While established toolboxes like TIMESAT have been extractin

Background: The aim was to develop a theoretical framework for how errors in estimated activities propagate to a dispersion in time-integrated activity in radionuclide-therapy dosimetry and how this affects the comparison of radionuclide-therapy dosimetry schemes. Methods: Formulae for the variance of relative errors of estimated time-integrated activities and relative differences in time-integrat

Rater agreement is commonly assessed in radiologic studies concerning image quality. There are several methods of measuring rater agreement. To choose the appropriate method, the researcher needs to consider the scale of the outcome variable and the design of the study. This article provides a brief overview of available methods, focusing on the most practical and commonly used, including intracla

Aphids cause massive agricultural losses through direct damage or as pathogen vectors. Control often relies on insecticides, which are expensive and not selective. An interesting alternative is to use aphid sex pheromones nepetalactone (NON) and nepetalactol (NOL) to interfere with aphid mating or attract aphid predators. Here, we explore production of these compounds in plants, as their precursor

The emergence of cyber mistreatment among frontline workers in their digital interactions with customers, clients and patients represents a significant but relatively new work environment risk within the service sector. Human resource management has a key role in digital transformation, which includes securing safe and healthy workplaces and fostering sustainable practices for handling cyber mistr

Developing an efficient code for large, multiscale astrophysical simulations is crucial in preparing for the upcoming era of exascale computing. RAMSES is an astrophysical simulation code that employs parallel processing based on the message-passing interface (MPI). However, it has limitations in computational and memory efficiency when using a large number of CPU cores. The problem stems from ine

We exhibit supercritical trade-off for monotone circuits, showing that there are functions computable by small circuits for which any small circuit must have depth superlinear or even super-polynomial in the number of variables, far exceeding the linear worst-case upper bound. We obtain similar trade-offs in proof complexity, where we establish the first size-depth trade-offs for cutting planes an

This Perspective suggests six conceptual propositions to advance care-centric planning and governance in support of SDG 11. By prioritizing relationships, responsiveness, and collective well-being, while also integrating empowerment, environmental stewardship, and cultural diversity, a care-centric approach fosters more inclusive and sustainable cities. Drawing on selected practice-based examples,

The lower infrastructure requirements of portable ultra-low field MRI (ULF-MRI) systems have enabled their use in diverse settings such as intensive care units and remote medical facilities. The UNITY Project is an international neuroimaging network harnessing this technology, deploying portable ULF-MRI systems globally to expand access to MRI for studies into brain development. Given the wide ran

Designing technologies that clothe, adorn, or are otherwise placed on the body raises questions concerning the role they will play in dressing ourselves. We situate self-fashioning - or the process through which we stylise and present our bodies - as a complex practice where a series of social, material, and contextual factors shape how we present ourselves. Informed by reflective discussions and

Antibiotics are used to treat both humans and animals for both preventive and therapeutic purposes. The overreliance on and misuse of antibiotics has given rise to a stealth pandemic, known as antimicrobial resistance (AMR). Globally, they pose a significant threat to human, animal, and environmental health. Surveillance of antibiotic residues in the environment, especially in wastewater, for tack