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Experimental studies suggest that hepatocyte growth factor (HGF) and its transmembrane tyrosine kinase receptor, Met, in part also relying on Akt kinase activity, mediate radioresistance. We investigated the importance of these biomarkers for the risk of ipsilateral breast tumour recurrence (IBTR) after adjuvant radiotherapy (RT) in primary breast cancer. HGF, phosphorylated Met (pMet) and phospho
Anaplastic large cell lymphomas (ALCLs) are rare CD30+ peripheral T-cell lymphomas (PTCLs) classified according to the expression of the anaplastic lymphoma kinase (ALK+) protein or not (ALK-). We have analysed the outcome and risk factors for survival in a population-based bi-national cohort of patients with systemic ALK+ ALCL. A total of 122 adult (≥18 years) patients diagnosed with ALK+ ALCL be
Urak Lawoi är en ursprungsbefolkning i Andamansjön som bl.a. bor på kända turistöar som Phuket, Phi Phi, Ko Lanta Yai och Ko Lipe utanför Thailands västkust. Deras språk och kultur skiljer sig från övriga thailändares, inte minst ifråga om kunskap att navigera på havet. Att bo på eller vid havet är centralt för deras identitet; det är där de fiskar, samlar föda på stränder och utför sina ritualer.On 26 December 2004, the Urak Lawoi sea people were hit by a huge tsunami that overwhelmed all of Southeast Asia causing the deaths of more than 350,000 people across the region. If the tsunami was the disaster, the “first wave”, the relief efforts and the assistance that came with it became the “second wave”, due to the social and economic changes that followed. The Urak Lawoi have for centuries,
The integrated dynamic ecosystem models SAFE and ForSAFEVEG were used to estimate critical loads for nitrogen using different chemical and biological criteria, and attempting to account for possible effects of climate change. The study is based on a model application on a set of 640 sites earlier used for critical loads assessments in Sweden, focusing on the ecological effect of nitrogen pollution
A cDNA clone (Mt4) was isolated as a result of a differential screen to identify genes showing altered expression during the interaction between Medicago truncatula and the vesicular-arbuscular mycorrhizal (VAM) fungus Glomus versiforme. Mt4 represents a M. truncatula, mRNA that contains numerous short open reading frames, the two longest of which are predicted to encode polypeptides of 51 amino a
Bulk properties of cortical bone have been well characterized experimentally, and potent toughening mechanisms, e.g., crack deflections, have been identified at the microscale. However, it is currently difficult to experimentally measure local damage properties and isolate their effect on the tissue fracture resistance. Instead, computer models can be used to analyze the impact of local characteri
We used eddy-covariance (EC) measurements of net ecosystem exchange (NEE) above canopy to assess the effects of thinning on CO2 fluxes at the ICOS Sweden site Norunda in central Sweden. This forest site consists of mixed pine and spruce stands approx. 100 years old. The thinning during late autumn 2008, performed in a semicircle from the mast extending 200m outwards harvested about 25% of the voluWe used eddy-covariance (EC) measurements of net ecosystem exchange (NEE) above canopy to assess the effects of thinning on CO2 fluxes at the ICOS Sweden site Norunda in central Sweden. This forest site consists of mixed pine and spruce stands approx. 100 years old. The thinning during late autumn 2008, performed in a semi-circle from the mast extending 200 m outwards harvested about 25% of the vo
Factor I (FI) is the major complement inhibitor that degrades Ob and C4b in the presence of cofactors such as factor H (FH) and membrane cofactor protein (MCP). Recently, mutations and polymorphisms in complement regulator molecules FH and MCP but also in FI have been associated with atypical hemolytic uremic syndrome (aHUS). HUS is a disorder characterized by hemolytic anemia, thrombocytopenia an
Previous work has suggested that given a hospital's need to admit more patients from the emergency department (ED), high inpatient bed occupancy may encourage premature hospital discharges that favor the hospital's need for beds over patients' medical interests. We argue that the effects of such action would be measurable as a greater proportion of unplanned hospital readmissions among patients di
Background: Single diffusion encoding is a widely used, noninvasive technique for probing the tissue microstructure in breast tumors. However, it does not provide detailed information about the microenvironmental complexity. This study investigated the clinical utility of tensor-valued diffusion encoding for evaluating microstructural changes in breast cancer after neoadjuvant chemotherapy (NAC).
In the seminal cases C-156/21 and C-157/21 (‘Budget Conditionality Cases’) the Court of Justice of the European Union demonstrated a shift in the perception of the operational functionality of foundational values of the EU, establishing that the rule of law is a founding value of the Union which represents a legal norm and imposes an obligation on the Member States to comply with its constituent e
This chapter departs from two research projects to present the learnings, methodological challenges, and recommendations when involving users in participatory approaches of design research in home care. In the first project, older participants collected data through solicited diaries and photo elicitation, reflecting about their use of multiple medications and difficulties experienced with medicat
Background: Different tau biomarkers become abnormal at different stages of Alzheimer’s disease (AD), with CSF p-tau typically being elevated at subthreshold levels of tau-PET binding. To capitalize on the temporal order of tau biomarker-abnormality and capture the earliest changes of tau accumulation, we selected a group of amyloid-β-positive (A+) individuals with elevated CSF p-tau levels but ne
Businesses are increasingly attracted to Emerging Markets due to the potential of increased demand for goods and services, driven mostly by macroeconomic trends in the external business environment. However, the business model approach for emerging markets differs from the one for developed markets as they are faced with a different set of demand and supply conditions. The purpose of this study is
Teachers in Sweden are instructed not just to teach their subject but also fundamental values. However, educators are given no guidelines as to how to do this. It therefore becomes relevant to research how language teachers can use literary works in school to ensure that students acquire knowledge about themes found in the curriculum, thus combining an important part from the subject’s contents wi
The web services that millions of people count on require large-scale computer resources (servers, nodes, networking) and an intricate set of interdependent software services. Under pressure to continually improve these services, code and configuration changes are deployed hundreds or thousands of times every day. Unforeseen issues and vulnerabilities during the deployment process can lead to cost
Denna uppsats har som syfte att genom fyra utvalda tal av den framstående abolitionisten Frederick Douglass se hur, genom hans tal, en svart människas värde skildras i USA under tiden kring det amerikanska inbördeskriget och genom vilka retoriska medel han nådde fram med sitt budskap. För att få svar på frågeställningarna har denna uppsats använts sig av Renbergs retorikanalys som teori och metod.
