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OBJECTIVE: Test the hypothesis that depressive symptoms are associated with cognitive performance and that cortisol levels may explain this association independently of Alzheimer's Disease (AD) biomarker levels.DESIGN: Longitudinal observational study.SETTING: Memory clinic, Karolinska University Hospital, Stockholm, Sweden.PARTICIPANTS: Consecutive patients (n = 162) who agreed to take part in th

Although prior falls are a well-established predictor of future fracture, there is currently limited evidence regarding the specific value of falls history in fracture risk assessment relative to that of other clinical risk factors and bone mineral density (BMD) measurement. We therefore investigated, across the three Osteoporotic Fractures in Men (MrOS) Study cohorts, whether past falls predicted

Objectives To identify the genetic determinants of fracture risk and assess the role of 15 clinical risk factors on osteoporotic fracture risk. Design Meta-analysis of genome wide association studies (GWAS) and a two-sample mendelian randomisation approach. Setting 25 cohorts from Europe, United States, east Asia, and Australia with genome wide genotyping and fracture data. Participants A discover

Recently, dimpled surfaces have found great attention due to their abilities in energy management and heat transfer enhancement, low weight, small values of pressure drop penalty, simple fabrication, and small maintenance costs. Many experimental and numerical studies are accomplished to investigate the potentials of dimpled surface technology in energy management of various thermal energy systems

Fatal intoxications with opioids are known to be associated with an increased lung weight, as well as with brain and pulmonary edema and urinary retention. However, there is evidence to suggest that fatal intoxications with non-opioid substances are also associated with increased lung weight; however, the latter aspect has not been comprehensively analyzed. To determine to what extent opioid and n

INTRODUCTION: This study examines the link between daytime and nighttime excessive sleep and cognition, cognitive decline, and dementia in individuals with existing mild cognitive impairment (MCI).METHODS: Using data from the Swedish longitudinal study Good Aging in Skåne, participants aged 60-102 years were retrospectively classified as MCI based on cognitive testing. The average follow-up time w

Summary: Screening initiatives for osteoporosis must facilitate treatment of those at elevated fracture risk. In a randomized controlled trial of 24,229 women, those in the screening group with FRAX ≥ 15% were invited for DXA with AOM treatment offered as per national guidelines. Treatment initiation in the following year was 9.5 times higher compared with controls. Purpose: To determine if screen

Background: Eosinophil-derived neurotoxin (EDN), an eosinophil granule protein, is a candidate biomarker in asthma to reflect eosinophilic activation. Objective: We sought to characterize the distribution of serum and nasal lavage fluid (NLF) EDN levels in different adult population subgroups and assess the determinants of high EDN levels. Methods: Serum and NLF samples were collected from a popul

ZnO-water nanofluid in an inner pipe was experimentally investigated to improve the thermal efficiency of double-pipe heat exchangers. In this work, a 57.6% increase in the Nusselt number was obtained at Re = 14,340 when the ZnO-water nanofluid flowed through a helically corrugated tube. It was found that helical corrugation played a more important role in heat transfer enhancement than thermophys

Attempts for higher output power and thermal efficiency of gas turbines make the inlet temperature of turbine to be far beyond the material melting temperature. Therefore, to protect the airfoil in gas turbine from hot gas and eventually prolong the lifetime of the blade, internal and film cooling structures with better thermal performance and cooling effectiveness are urgently needed. However, th

In 2016, the European Hematology Association (EHA) published the EHA Roadmap for European Hematology Research1 aiming to highlight achievements in the diagnostics and treatment of blood disorders, and to better inform European policy makers and other stakeholders about the urgent clinical and scientific needs and priorities in the field of hematology. Each section was coordinated by 1–2 section ed

This book comprises the select proceedings of the International Conference on Future Learning Aspects of Mechanical Engineering (FLAME 2020). This volume focuses on current research in fluid and thermal engineering and covers topics such as heat transfer enhancement and heat transfer equipment, heat transfer in nuclear applications, microscale and nanoscale transport, multiphase transport and phas

A 180-deg turning channel can be seen in many heat exchange systems, and a strong three-dimensional flow phenomenon will occur at the turning point. In order to strengthen the heat transfer inside the turn and considering the lack of relevant enhanced endwall heat transfer approach, the present study innovatively demonstrates the measures of enhanced internal endwall heat transfer using arrays of

Study Objectives: Individuals with evening chronotype have a higher risk of cardiovascular and metabolic disorders, although the underlying mechanisms are not well understood. In a population-based cohort, we aimed to investigate the association between chronotype and 242 circulating proteins from three panels of established or candidate biomarkers of cardiometabolic processes. Methods: In 2,471 p

The oxidation and reduction of an Ir(100) surface using 2.5, 5, and 10 mbar O2partial pressure and a sample temperature of 775 K have been studied by using high-energy surface X-ray diffraction (HESXRD) which allowed to record large volumes of reciprocal space in short time periods. The complex 3D diffraction patterns could be disentangled in a stepwise procedure. For the 2.5 mbar experiment the m

This work aims to analyze thermal performance for an electric heater filled with different nanofluids, including SiO2-water nanofluid, Fe3O4-water nanofluid, and Cu-water nanofluid. The effect of nanoparticle concentration (0.1–2.0 wt%) is also discussed. Results indicate that Cu-water nanofluids show better heat transfer performance than the other nanofluids. The highest heating efficiency for th

This work provides a new method to enhance endwall heat transfer of a sharp turn channel. Several longitudinal vortex generators (LVGs) at various spacing and aspect ratio are placed in parallel on the inner side of endwall in a sharp turn channel. Liquid crystal thermography, pressure difference measurements, and a statistical method are applied to analyze the thermal behavior, friction factor, a

Atomic layer deposition (ALD) is an outstanding deposition technique to deposit highly conformal and uniform thin films with atomic precision. In particular, ALD of transition metal oxide layers from metal amido complexes and water finds its way in several technological fields, including green energy devices and in the semiconductor industry. These ALD reactions are believed to follow a reaction s

X-ray free-electron lasers (XFELs) provide high-brilliance pulses, which offer unique opportunities for coherent X-ray imaging techniques, such as in-line holography. One of the fundamental steps to process in-line holographic data is flat-field correction, which mitigates imaging artifacts and, in turn, enables phase reconstructions. However, conventional flat-field correction approaches cannot c