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Therapeutic resistance and recurrence remain core challenges in cancer therapy. How therapy resistance arises is currently not fully understood with tumors surviving via multiple alternative routes. Here, we demonstrate that a subset of cancer cells survives therapeutic stress by entering a transient state characterized by whole-genome doubling. At the onset of the polyploidization program, we ide

The identification of helium nuclei at LHCb is achieved using a method based on measurements of ionisation losses in the silicon sensors and timing measurements in the Outer Tracker drift tubes. The background from photon conversions is reduced using the RICH detectors and an isolation requirement. The method is developed using pp collision data at √s = 13 TeV recorded by the LHCb experiment in th

The aim of ADINE project is to develop and to demonstrate new methods for the electric distribution network management including distributed generation (DG). The active network management (ANM) method needs enabling solutions such as protection, voltage and reactive power control and planning and information systems of networks. The actual devices and monitored data from the real-life demonstratio

Fluorescence techniques for applications in tissue diagnostics and therapy monitoring were investigated and developed in the work presented in this thesis. The aim was to develop fluorescence diagnostics for the detection of malignant tumors and better delimitation of the tumor margins, using the enhanced contrast in fluorescence between tumor and surrounding healthy tissue. Fluorescence may be ge

Popular Abstract in Swedish Avloppsvatten renas från fosfor för att minimera utsläppet till sjöar och hav. Näringsämnena fosfor och kväve bidrar till övergödningen i våra vatten och kan reduceras kraftigt på avloppsreningsverken. Fosforavskiljning går huvudsakligen ut på att få löst fosfat att hamna i en fast fas ? slammet, för att sedan kunna avskilja det från det renade vattnet. Bakterier som vThe idea of phosphorus removal at wastewater treatment plants is to transfer dissolved phosphorus into a solid phase. Together with the rest of the produced sludge it is then removed from the water, resulting in a decreased concentration of phosphorus in the effluent and the prevention of the eutrophication in the recipient. Phosphorus can either be stored biologically, with enhanced biological p

Al2O3 and HfO2 high-k oxides deposited by atomic layer deposition have been studied on InAs 100 and 111B surfaces. By using a low-frequency fitting routine, interface defect densities have been extracted. In general, both HfO2 and Al2O3 show similar D-it profiles, with a D-it minimum around 2x10(12) eV(-1)cm(-2).

Five sets of gloves were tested on 3 hand models with 2 measuring system in order to ensure repeatability of results from the past and for the future. The other aims of the study were to compare the possible differences related to different number of measuring zones, and effect of temperature distribution over hand surface. The hand models had 2 (HF), 9 (H2) and 10 (H3) zones respectively. Models

Popular Abstract in Swedish Dagens storskaliga tillverkning baseras på varor med relativt kort livstid och lågt pris. Vinsterna för tillverkarna kommer från den stora mängden sålda varor. Det finns dock inom många industribranscher krympande vinstmarginaler och många företag söker därför efter nya källor för att uppnå bättre rörelseresultat. Även miljöfrågorna är en utmaning för industrin. VäxandeLife cycle environmental problems have been addressed by a number of strategies. However, the results are mostly lamentable because solutions are searched for within the same paradigms that give rise to the problems. This research questions the vision of linear material growth and searches for ways to sustain economic growth without putting the natural environment under stress. The research explor

Treatment resistant depression (TRD) and suicidal behavior are among the most important public health problems and are commonly associated with significant disability and psychosocial impairment. Although there have been recent advances in identifying neurobiological correlates of these complex conditions, their pathophysiology still remains unclear. Although the recent advances concerning the neu

This paper presents an acoustofluidic chip for the sorting of bacteria from protozoa in water using standing acoustic waves. The size-based acoustophoretic sorting method provides a means for sample pre-concentration, which is vital for real-time, on-site monitoring of drinking water quality and preventing outbreak of waterborne diseases. In practice, high throughput and high recovery pre-concentr

Popular Abstract in Swedish Människors sätt att visualisera objekt bygger på en del underliggande principer som man kanske inte alltid reflekterar över. Det faktum att vi har just två ögon gör det till exempel möjligt för oss att avgöra på vilket avstånd ett objekt befinner sig. Detta kallas för parallaxeffekten. Kameror, som bara har ett "öga", saknar denna förmåga, vilket försvårar avbildande mäLaser sheet imaging, also known as planar laser imaging, is one of the most versatile optical imaging techniques known and is frequently applied in several different domains. It furthermore constitutes the basis for a variety of other 2D methods, in turn allowing visualization of e.g. velocity, particle size, species concentration and temperature. However, when applied on turbid, light scattering

Purpose: Various food patterns have been associated with weight change in adults, but it is unknown which combinations of nutrients may account for such observations. We investigated associations between main nutrient patterns and prospective weight change in adults. Methods: This study includes 235,880 participants, 25–70 years old, recruited between 1992 and 2000 in 10 European countries. Intake

This work focuses on the investigation on both local and global dielectric properties for a random wound single tooth winding, which represents a segment of the in-field electrical machine used on an Hybrid Wheel Loader. Finite Element Analysis (FEA) is used to predict the temperature stress while loading and illustrate the influences of dielectric properties (i.e. conductivity and dielectric cons

We present an assay, based on optical DNA mapping in nanochannels that is capable of characterizing the plasmid content of bacterial isolates resistant to antibiotics in a fast an detailed way. In a single experiment we determine the number of different plasmids in each sample, their size, as well as a barcode that can be used for plasmid identification and tracing. In addition we demonstrate that

The number of patients affected by Alzheimer's disease among the population is currently growing, while the availability of resources for their assistance is decreasing. A solution for this problem is provided by the use of Ambient Assisted Living technologies, with the objectives to prolong the independent living of patients at home, to relieve assistance burden on caregivers, and to improve care

Can Machine Learning Provide more Insights in Cardiovascular Disease? Cardiovascular (CV) disease is the main cause of morbidity and mortality all over the world and the number of people suffering from CV complications is growing as the population is getting older. Despite of knowing several risk factors such as age, hypertension, body mass index (BMI) and genetics associated to CV complication,

The aim of this report was to study possibilities of making the process of extracting lignin from black liquor at pulp and paper mills more efficient in the form of a literature study. Lignin is a commodity that is likely to become more valuable in the future due to work being done by a number of companies in utilizing it as for example a base for the production of renewable fuels and carbon fibre

Källmiljöer är grundvattenberoende ekosystem med en betydande roll för den biologiska mångfalden. Svenska skogar är rika på källor, som riskerar att påverkas av närliggande skogsbruk. I EU-projektet GRIP on LIFE IP som bland annat Skogsstyrelsen deltar i ska våtmarker och vattendrag uppmärksammas och eventuellt restaureras och i dessa naturområden ingår källmiljöer. Syftet med detta examensarbete Spring environments are groundwater dependent ecosystems, which play an important role for biodiversity. In Swedish forests there is an abundance of springs, many of which risk being affected by forestry nearby. In the EU project GRIP on LIFE IP where, among others, the Swedish Forest Agency take part, wetlands and streams will be brought to attention and possibly restored. In these biotopes, spri

Pritam Kumarsingh A Case Study to develop and test GIS/SDSS methods to assess the production capacity of a Cocoa Site in Trinidad and Tobago Trinidad and Tobago has achieved world-wide affirmation for its unique fine and flavour cocoa (Theobroma cacao). This classification of cocoa commands price premiums on the global market. However, the industry has declined over years. Investors and farmers

The acoustic emission that is detectable in the forming of complex thin part plates contains information about the quality of the pressed plates. The information can be used as process control and to filter out advanced thin plates with defects such as cracks. The article describes the results obtained in a try-out pressing process in special developed punch-die pairs with different pressing