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Type 1 diabetes associated genes account for less than 50% of disease susceptibility. Human enteroviruses have been implicated as environmental factors that might trigger and/or accelerate this autoimmune disorder. We now report of a 12-year-old girl that developed pancreatic autoimmunity and type 1 diabetes after enteroviral infection. Diabetes-associated autoimmunity was evaluated by measurement

In this paper, the role and significance of opinion-shaping and persuasion activities are explored through an analysis of the activation of women in the Swedish labour market in the 1960s, highlighting the ways in which gender equality ideals became infused in these activities through a process of ‘transformative state feminism’. The analysis draws on qualitative data including archival material a

Extending the use of Monte Carlo (MC) event generators to jets in nuclear collisions requires a probabilistic implementation of the non-abelian LPM effect. We demonstrate that a local, probabilistic MC implementation based on the concept of formation times can account fully for the LPM-effect. The main features of the analytically known eikonal and collinear approximation can be reproduced, but we

Many important scientific questions in physics, chemistry and biology require effective methodologies to spectroscopically probeultrafast intra- and inter-atomic/molecular dynamics. However, current methods that extend into the femtosecond regime arecapable of only point measurements or single-snapshot visualizations and thus lack the capability to perform ultrafast spectroscopicvideography of dynMany important scientific questions in physics, chemistry and biology require effective methodologies to spectroscopically probe ultrafast intra- and inter-atomic/molecular dynamics. However, current methods that extend into the femtosecond regime are capable of only point measurements or single-snapshot visualizations and thus lack the capability to perform ultrafast spectroscopic videography of

The failing ecosystem services in Thika-Chania catchment is manifested in the deterioration of water quality, sedimentation of reservoirs, and subsequent increase in water treatment costs due to high turbidity. The services can be restored by implementing relevant soil and water conservation practices to enhance flow regulation and control sediment yield. The impacts of contour farming and filter

Fungi have the capacity to cause devastating diseases of both plants and animals, causing significant harvest losses that threaten food security and human mycoses with high mortality rates. As a consequence, there is a critical need to promote development of new antifungal drugs, which requires a comprehensive molecular knowledge of fungal pathogenesis. In this review, we critically evaluate curre

In this population-based, case-control study from Sweden using data collected from 1988 to 1990, an increased risk of melanoma was associated with the number of sunburns, propensity to freckle, the number of raised naevi and a family history of melanoma. Furthermore, a decreased risk was associated with occupational sun exposure. The purpose of this study was to investigate whether different histo

Mitonuclear discordance across taxa is increasingly recognized as posing a major challenge to species delimitation based on DNA sequence data. Integrative taxonomy has been proposed as a promising framework to help address this problem. However, we still lack compelling empirical evidence scrutinizing the efficacy of integrative taxonomy in relation to, for instance, complex introgression scenario

In order to avoid environmental pollution and eliminate the need for using fertiliser, this study assessed for the first time the optimum performance of mature (in operation since 2011) vertical flow constructed wetlands in treating domestic wastewater (with and without hydrocarbon) and the subsequent recycling of the outflow to irrigate chillies (De Cayenne; Capsicum annuum (Linnaeus) Longum Grou

Hutchinsoniella macracantha is a simultaneous hermaphrodite. The small, paired ovaries are cephalic. From each, a long oviduct runs posteriorly to the eighteenth trunk segment, where it loops forward and runs toward the sixth trunk segment. The paired, sausage-shaped testes are dorsal to the midgut in the anterior end of the abdomen. A vas deferens runs down from the anterior end of each testis to

BACKGROUND: Accumulating evidence supports a role for the immune system in the pathogenesis of Parkinson's disease. Importantly, recent preclinical studies are now suggesting a specific contribution of inflammation to the α-synuclein-induced pathology seen in this condition.METHODS: We used flow cytometry and western blots to detect toll-like receptor 2 and 4 expression in blood and brain samples

Across today’s developed world, there is a clear mortality gradient by socioeconomic status for all ages. It is often taken for granted that this gradient was as strong—or even stronger—in the past when social transfers were rudimentary and health care systems were less developed. Some studies based on cross-sectional data have supported this view, but others based on longitudinal data found that

The serine synthesis pathway comprises three steps, and genetic defects are known in each of these: 3-phosphoglycerate dehydrogenase deficiency, phosphoserine aminotransferase deficiency and 3-phosphoserine phosphatase deficiency. The former has been reported in 24 patients. The majority of these patients have a severe infantile phenotype consisting of congenital microcephaly, intractable seizures