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Based on concepts from quantum thermodynamics, the two-level system coupled to a single electromagneticmode is analyzed. Focusing on the case of detuning, where the mode frequency does not match the transitionfrequency, effective energies are derived for the levels and the photon energy. It is shown that these should be usedfor energy exchange with fermionic and bosonic reservoirs in the steady st

PURPOSE: To determine the impact of the implementation of novel systemic regimens and locoregional treatment modalities on survival at population level in colorectal cancer (CRC) patients presenting with peritoneal metastases (PMs).METHODS: All consecutive CRC patients with synchronous PM (<3 months) between 1995 and 2014 were extracted from the Eindhoven area of the Netherlands Cancer Registry. T

How does violent conflict affect the spread of Covid-19? In this paper we analyze how violent conflict influences the adoption of preventative measures and infection rate in a very poor, conflict-affected country, Burkina Faso. We use a unique panel of 1,919 households surveyed during the first six months of the Covid-19 pandemic in 2020 and merge these data with indicators of violence at the muni

The Facility for Antiproton and Ion Research (FAIR) in Darmstadt, Germany, provides unique possibilities for a new generation of hadron-, nuclear- and atomic physics experiments. The future antiProton ANnihilations at DArmstadt (PANDA or P ¯ ANDA) experiment at FAIR will offer a broad physics programme, covering different aspects of the strong interaction. Understanding the latter in the non-pertu

Protein AA, the major repetitive protein subunit present in fibrils deposited in AA-amyloidosis, is an N-terminal cleavage product of a 104-amino acid precursor, serum amyloid A (SAA). Protein AA subspecies varying between 45 and 94 amino acids in length have been described. In this study it is shown that the different protein AA subspecies are not evenly distributed in amyloid deposits and that i

A series of worldwide projects concerning assessment, student outcomes and quality in higher education has revealed the need for a change in how higher education institutions assess student outcomes; however, many academics remain unconvinced. The success of assessment change arguably depends on the assessment culture within the institution. This qualitative investigation of assessment cultures dr

It has often been stated that the Chronographia by the eleventh-century prolific author Michael Psellos is a piece of historiography that reads almost like a novel, and that Psellos spends much time on describing characters and taking ironical stances towards his imperial protagonists. This article claims that a refined version of this may be seen in Psellos’ book six on Constantine IX Monomachos.

Despite a lot of research in the field, only very little experience exists with Teaching by Demonstration (TbD) in actual industrial use cases. In the factory of the future, it is necessary to rapidly reprogram flexible mobile manipulators to perform new tasks, when the need arises, for which a working system capable of TbD would be ideal. Contrary to current TbD approaches, that generally aim to

We apply the random-phase approximation to two-photon ionization. We develop a formalism which, by means of screened electron-photon interactions, includes the nonlinear response and, in particular, double-excitation processes. The theory is illustrated by numerical calculations of the two-photon ionization cross section of the external (5p and 5s) shell of xenon, over a large energy range: from t

We present experimental results of harmonic generation at 1064 nm using a 36-ps neodymium-doped yttrium aluminum garnet laser tightly focused in a gas jet of xenon. The harmonic yields are studied as a function of the position of the focus in the jet at several laser intensities and as a function of intensity at several focus positions. These results bring information about how the high harmonics

The objective of control flow obfuscation is to protect the program control flow from analysis. A technique called control flow flattening addresses static analysis by hiding edges between basic blocks in a program and introduces a dispatcher block that determines the execution order of the randomized blocks.In this paper we propose a novel flattening construction and lightweight dispatchers that

In the age of miniaturization where the physical systems approach the nanoscale limit andwhere more complex materials are created there is necessity for understanding in terms ofquantum mechanics. The understanding then opens and gives possibilities for manipulationand engineering of such systems and thus practical applications.Quantum mechanics states that the electron cannot be characterized as In this thesis we focus on improvements of the description of the electron-electron correlation effects in nonequilibrium nanosystems. We mainly focus on developments of two nonequilibrium methods, namely the formalism of Nonequilibrium Green’s Function and Time Dependent Density Functional Theory and we explore the possibility to improve existing approximations in these theories. A smaller part o

In Sweden social work with homeless people is dominated by “Treatment First” (or the staircase model). The Treatment First models weak results in combating homelessness has increased the interest for Housing First. In 2015 we started a participatory design-oriented research project in the City of Helsingborg in Sweden that aims to implement principles of Housing First in a social housing programme

The excavation of a low-temperature kiln structure at an affluent Iron Age regional center, Uppåkra, located in southern Sweden, revealed from archeobotanical samples and its context evidence of malting in the process to make beer. Carbonized germinated hulled barley grain (Hordeum vulgare) was recovered from the kiln structure itself and from the surrounding occupationalsurface. Located somewhat

Patients with alkaptonuria lack homogentisate 1,2-dioxygenase leading to retention of homogentistic acid (HGA) in body fluids and eventually to tissue deposition of oxidation products, giving rise to the clinical picture of ochronosis. Ascorbic acid is a known inhibitor of the enzyme which catalyses the oxidation of homogentisic acid (HGA) to the polymer with affinity for collagen and was used in

Intravenous immunoglobulin (IVIG) has been used to treat many autoimmune disorders including Stiff-Man Syndrome (SMS). SMS is a neurological disorder associated with an immune-mediated deficiency of gamma-aminobutyric acid (GABA) due to autoantibodies against the GABA synthesizing enzyme glutamic acid decarboxylase-65 (GAD65). GAD65 autoantibodies are present among 1-2% of healthy individuals. It

Glutamic acid decarboxylase (GAD) enzymes catalyse the formation of gamma-aminobuturic acid (GABA), which is a major transmittor in the central nervous system but also exerts functions in peripheral organs. Recent molecular analyses have revealed surprising new roles for the GAD isoforms in human diseases of autoimmune character including neurological disorders and insulin-dependent diabetes. In t