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Three-dimensional simulations of the squealer tip on the GE-E-3 blade with eight film cooling holes were carried out. The effect of the rim width and the blowing ratio on the blade tip flow and cooling performance were revealed. Numerical simulations were performed to predict the leakage flow and the tip heat transfer with the k-epsilon model. For the squealer tip, the depth of the cavity is fixed
In this work we present the first XOS degrading glycoside hydrolase from Weissella, WXyn43, a two-domain enzyme from GH43. The gene was amplified from genomic DNA of the XOS utilizing Weissella strain 92, classified under the species pair Weissella cibaria/W.confusa, and expressed in Escherichia coli. The enzyme is lacking a putative signal peptide and is, from a homology model, shown to be compos
Induced pluripotent stem cells (iPSCs) generated from somatic cells of patients can be used to model different human diseases. They may also serve as sources of transplantable cells that can be used in novel cell therapies. Here, we analyzed neuronal properties of an iPSC line derived from a patient with a juvenile form of Huntington's disease (HD) carrying 72 CAG repeats (HD-iPSC). Although its i
We present a novel design for a macrostructured cathode that can be coated with a thin layer of the B-10 solid converter and mounted to replace the Boron-lined flat parallel plates of a proportional counter used for slow neutron detection. The proposed design consists of a 3D regular pattern exhibiting millimeter deep grooves with an opening angle of alpha = 45 degrees, which could be created in t
This paper presents a literature review about energy-efficient retrofit of electric lighting and daylighting systems in buildings. The review, which covers around 160 research articles, addresses the following themes: 1) retrofitting electric lighting in buildings, 2) electric lighting energy use and saving potential and 3) lighting retrofit strategies. The retrofit strategies covered in the revie
The mechanoreceptive lateral line system in fishes detects hydrodynamic stimuli and plays a critical role in many fundamental behaviours, including orientation to water currents and the detection of stationary objects, prey and predators. Interspecific variation in lateral line structure may result from a process of functional adaptation, with the background level of hydrodynamic activity proposed
In this study, a tetracycline-regulated lentiviral vector system, based on the tetracycline-dependent transactivator rtTA2S-M2, was developed for controlled expression of glial cell line-derived neurotrophic factor (GDNF) in the rat brain. Expression of the marker gene green fluorescent protein (GFP) and GDNF was tightly regulated in a dose-dependent manner in neural cell lines in vitro. Injection
In a prospective study we tested the hypothesis that a cry from an infant can be used as part of an instrument to measure pain. Ten healthy newly born infants were subjected to painful stimuli on four occasions during their first year of life. The sound of the crying was analysed with regard to duration. With the help of a sound spectrogram, the fundamental frequencies of the first five crying sou
Here, the ligand binding, activation, and tissue distribution of the orphan G protein-coupled receptor (GPCR) GPR92 were studied. GPR92 binds and is activated by compounds based on the lysophosphatidic acid (LPA) backbone. The binding of LPA to GPR92 was of high affinity (K(D) = 6.4 +/- 0.9 nM) and led to an increase in both phosphoinositide hydrolysis and cAMP production. GPR92 is atypical in tha
Today, driver support tools intended to increase traffic safety, provide the driver with convenient information and guidance, or save time are becoming more common. However, few systems have the primary aim of reducing the environmental effects of driving. The aim of this project was to estimate the potential for reducing fuel consumption and thus the emission of CO, through a navigation system wh
As an emerging country, Vietnam needs competent business entrepreneurs who are expected to modernize the economy, renew business and management practices, and develop sustainable growth strategies. The mission of business and management education, thus, is to prepare graduate students for the development of transitional Vietnam and future global challenges. Graduates’ competency, according to comp
Despite recent technological advancements allowing the characterization of cancers at a molecular level along with biomarkers for cancer diagnosis, the management of ovarian cancers (OC) remains challenging. Proteins assume functions encoded by the genome and the complete set of proteins, termed the proteome, reflects the health state. Comprehending the circulatory proteomic profiles for OC subtyp
It is well-recognized in historical scholarship that in both Japan and the West, expositions were an important site for the dissemination of colonial propaganda in the decades surrounding the turn of the twentieth century. Nevertheless, the question of how colonial themes were perceived and understood by visitors to these events remains largely unanswered in this literature. This essay reflects on
This paper provides a detailed, longitudinal study of the role and strategies of the Chinese Institute of Certified Public Accountants (CICPA) in building a Chinese home-grown public accounting profession since the late 1980s. Drawing on previously unaccessed archive materials and a series of interviews with senior representatives of the Chinese public accounting profession, this paper reveals a m
IntroductionEmerging evidence suggests a difference in access to facilities for medical termination of pregnancy (MTP) and delivery among women in different regions of the country. However, we lack assessments at a large scale across all geographies. Our study aims to describe the percent contribution of private and public sectors in institutional deliveries and MTP in India.MethodsA secondary dat
Background: Due to a large variety in treatment outcomes reported in therapeutic trials and lacking patient-relevant outcomes, it is hard to adequately compare and improve current therapies for patients with capillary malformations (CMs). The Core Outcome Set for Capillary Malformations (COSCAM) project aims to develop a core outcome set (COS) for use in future CM trials, in which we will first de
