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Immune thrombocytopenia (ITP) is an autoimmune disease characterized by an isolated thrombocytopenia and variable phenotype as some patients suffer no bleeding whilst others have bleeding from mild to severe, which may be fatal. This variability probably reflects the disease's complex pathophysiology; a dysregulated hyperreactive immune effector cell response involving the entire adaptive immune s
INTRODUCTION: Depression is a risk factor and possible prodromal symptom of Alzheimer's disease (AD), but little is known about subsequent risk of developing depression in persons with AD. METHODS: National matched cohort study was conducted of all 129,410 persons diagnosed with AD and 390,088 with all-cause dementia during 1998–2017 in Sweden, and 3,900,880 age- and sex-matched controls without d
Family disaster planning and preparation demands proactive acknowledgment and accommodation of individuals with disabilities. This study, based on interviews with families including members with disabilities, uncovers insights on information gaps, adaptive strategies, technology use, and support networks. Contributing to disaster and disability studies, resilience, and crisis planning, it highligh
Conformational changes are crucial for the catalytic action of many enzymes. A prototypical and well-studied example is loop opening and closure in triosephosphate isomerase (TIM), which is thought to determine the rate of catalytic turnover in many circumstances. Specifically, TIM loop 6 "grips" the phosphodianion of the substrate and, together with a change in loop 7, sets up the TIM active site
Metal ions are both ubiquitous to and crucial in biology. In classical simulations, they are typically described as simple van der Waals spheres, making it difficult to provide reliable force field descriptions for them. An alternative is given by nonbonded dummy models, in which the central metal atom is surrounded by dummy particles that each carry a partial charge. While such dummy models alrea
Flooding is one of the natural hazards that pose the most serious threat to human societies in Rwanda, particularly in the Sebeya catchment located in the northwestern part of the country. The main aims of this study are to identify the current flooding issues in the Sebeya catchment in Rwanda and to propose recommendations for improved flood risk management (FRM). The methodology employed encompa
The rapid proliferation of data across diverse fields has accentuated the importance of accurate imputation for missing values. This task is crucial for ensuring data integrity and deriving meaningful insights. In response to this challenge, we present Xputer, a novel imputation tool that adeptly integrates Non-negative Matrix Factorization (NMF) with the predictive strengths of XGBoost. One of Xp
The extent to which bullying victimization is associated with an increased risk of obsessive-compulsive disorder (OCD) has received little empirical attention. This longitudinal, population-based, genetically informative study examined whether self-reported bullying victimization at age 15 was associated with a clinical diagnosis of OCD in the Swedish National Patient Register and with self-report
Aims: Men are more likely to suffer a myocardial infarction than women, but population-based studies on sex differences in imaging-detected atherosclerosis are lacking. The aims were to assess sex differences in the prevalence of imaging-detected coronary and carotid atherosclerosis, as well as multivariable adjusted associations between sex and atherosclerosis. Methods and results: Participants a
Novel coordinatively saturated platinum(ii) compounds bearing C-linked carbohydrates were synthesized and characterized. The complexes exhibit bipyramidal trigonal geometry with a bidentate nitrogen ligand and ethylene in the equatorial plane. The axial positions are occupied by a halide ligand X and a d-galactose or d-glucose derivative, linked either via C1 or C6. The compounds were designed for
Quark spin effects in e+e- annihilation to pseudoscalar and vector mesons are implemented for the first time in the pythia Monte Carlo event generator. The spin-dependent fragmentation of the string stretched between the produced quark-antiquark pair with correlated spin states is described by the string+P30 model implemented in the string fragmentation routine of pythia by using the StringSpinner
The power take-off (PTO) system and control laws for wave energy converters (WECs) are crucial for system performance. Determining optimal PTO parameters based on different sea states is key for formulating control laws, identifying optimal WEC locations, and optimizing wave-to-wire performance. This study focuses on an oscillating water column (OWC) type WEC developed by Waves4Power using a buoy
This paper presents a method for evaluating the potential for injury in any traffic scenario involving road user interactions based on trajectory data from a few hours of data of typical traffic conditions. The basic idea was to evaluate to what extent interactions at a location are limited in speed, direction, and whether the interactions happen at a safe speed. Specifically, the method works by
In the design of a wave energy converter (WEC) in general, one critical aspect is to develop thepower take-off (PTO) system since it has a significant impact on the overall energy harnessing efficiency. There-fore, the modelling of a PTO system should be considered in the simulation of a WEC and carefully tuned with itsparameters to guarantee prediction accuracy. However, it is a challenge to mode
Existing datasets for autonomous driving (AD) often lack diversity and long-range capabilities, focusing instead on 360° perception and temporal reasoning. To address this gap, we introduce Zenseact Open Dataset (ZOD), a large- scale and diverse multimodal dataset collected over two years in various European countries, covering an area 9×that of existing datasets. ZOD boasts the highest range and
We report on a twisted aromatic polymer,the first xanthene-based example bearing protonated imidazole groups. Its specialarchitecture enables superior ion selectivity, conductivity, and chemicalstability, providing excellent performance in both all-vanadium and iron-vanadiumredox flow batteries.
Although urban scenario planning is widely applied for exploring various directions of urban development, it often has high requirements on the medium of quantitative information analysis and transformation. Thus, this study establishes a method of combining scenario planning with a spatial dynamic planning support system to predict urban growth. Specifically, a scenario-based spatial dynamic mode
Background: Although glomerular diseases are the third most frequent cause of end-stage kidney disease worldwide, little is known about their long-term outcomes. Methods: In patients with chronic kidney disease (CKD) stage 3–5 enrolled in the Swedish Renal Registry, we compared risks of hospitalization, kidney replacement therapy (KRT), major cardiovascular events (MACE), and death of the four mos
Lead (Pb) is a global contaminant associated with multiple adverse health effects. Humans are especially vulnerable during critical developmental stages. During pregnancy, exposure to Pb can occur through diet and release from maternal bones. Apolipoprotein E gene (APOE) variants (ɛ2, ɛ3, ɛ4 alleles) may influence sex steroid hormones, bone metabolism, and Pb kinetics. We examined the interplay am
