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Background: The discovery of disease-associated loci through genome-wide association studies (GWAS) is the leading genetic approach to the identification of novel biological pathways underlying diseases in humans. Until recently, GWAS in ischaemic stroke have been limited by small sample sizes and have yielded few loci associated with ischaemic stroke. We did a large-scale GWAS to identify additio

This thesis is concerned with spoken dialogue and the dynamic negotiation of meaning in English conversation. It serves two aims, one theoretical and the other practical. The theoretical aim is to further our understanding of the kinds of properties that influence the meaning of constructions in spoken dialogue and the role of underlying socio-cognitive processes. The practical aim is to compile a

Innovation in retailing is under-investigated in academia and yet a highly relevant concern given the current changes in the retail landscape. Although retailing is often characterized by a dynamic and highly competitive environment, retail organi- zations are not often considered as ‘innovative,’ at least when compared with manufacturing industries, or when using exist- ing innovation frameworks

This study explores if self-control predicts exercise ambition and actual exercise, and if exercise ambition predicts actual exercise. Members and guests at a not-for-profit sports club were invited to participate. 264 individuals completed a self-reported (Self-Control Scale) measure of self-control, and responded to questions about actual exercise as well as exercise ambition prior to their work

Self-adaptation provides a principled way to deal with software systems' uncertainty during operation. Examples of such uncertainties are disturbances in the environment, variations in sensor readings, and changes in user requirements. As more systems with strict goals require self-adaptation, the need for formal guarantees in self-adaptive systems is becoming a high-priority concern. Designing se

Objectives Global incidence and attention to childhood cancer is increasing and treatment abandonment is a major cause of treatment failure in low-and middle-income countries. The purpose of this study was to gain an understanding of factors contributing to non-adherence to treatment. Design A prospective cohort study with 2 year follow-up of incidence, family-reported motives and risk factors. Se

The Advanced Light Source (ALS) at Berkeley Lab has seen many upgrades over the years, keeping it one of the brightest sources for soft x-rays worldwide. Recent developments in magnet technology and lattice design appear to open the door for very large further increases in brightness [1], particularly by reducing the horizontal emittance, even within the space constraints of the existing tunnel. I

The Advanced Light Source (ALS) at Berkeley Lab has seen many upgrades over the years, keeping it one of the brightest sources for soft x-rays worldwide. Recent developments in magnet and vacuum technology, as well as lattice design (multi bend achromat lattices) appear to open the door for very large further increases in brightness [1]. This could be achieved by reducing the horizontal emittance,

The yeast Candida glabrata is a major opportunistic pathogen causing mucosal and systemic infections in humans. Systemic infections caused by this yeast have high mortality rates and are difficult to treat due to this yeast's intrinsic and frequently adapting antifungal resistance. To understand and treat C. glabrata infections, it is essential to investigate the molecular basis of C. glabrata vir

OBJECTIVE: The aim of this study was to compare and validate the different classifications of severity in acute pancreatitis (AP) and to investigate which characteristics of the disease are associated with worse outcomes. SUMMARY OF BACKGROUND DATA: AP is a heterogeneous disease, ranging from uneventful cases to patients with considerable morbidity and high mortality rates. Severity classification

BACKGROUND: Drug-related problems due to medication errors are common and have the potential to cause harm. This study, which was conducted in Swedish primary health care, aimed to assess how well the medication lists in the medical records tally with the medications used by patients and to explore what type of medication errors are present. METHODS: We reviewed the electronic medical records (EMR

One of the most frequently mutated proteins in human B-lineage leukemia is the transcription factor PAX5. These mutations often result in partial rather than complete loss of function of the transcription factor. While the functional dose of PAX5 has a clear connection to human malignancy, there is limited evidence for that heterozygote loss of PAX5 have a dramatic effect on the development and fu

For some time, tourism researchers have sought to examine and theorise types of collaborative exchange and the characteristics of relational work in tourism. Different ontological and epistemological framings, and associated language games have contributed to a fragmented body of knowledge. In this paper, we argue that the new term ‘co-creation’ is part of this language game, and efforts to date h

Public sector services are complex in relation to many private sector services. For example, public sector services contain non-voluntary service interaction. This area of practice has not been extensively researched to date. In this article, we explore and discuss service interaction in public non-voluntary services targeting children, in order to understand what elements go into value co-creatio

The intensification of agricultural practices throughout the twentieth century has had large detrimental effects on biodiversity and these are likely to increase as the human population rises, with consequent pressure on land. To offset these negative impacts, agri-environment schemes have been widely implemented, offering financial incentives for land-owners to create or maintain favourable habit

Rwanda har sedan 2006 aktivt arbetat för att modernisera jordbrukssektorn med syftet att ersätta småskaliga självförsörjande jordbruk med moderna, marknadsorienterade. I denna process har småskaliga jordbrukare tvingats att överge sina traditionella grödor och jordbruksmetoder för att anpassa sig till odling i monokultur utvalt av staten på sammanslagna jordlotter.Avhandlingen, baserad på 13 månadSince 2006, Rwanda has been implementing policies to modernize the agricultural sector, with the aim of moving from small-scale subsistence farming to modern, market-oriented farming. Under these policies, small-scale farmers have been compelled to abandon their traditional farming practices and adapt to monocropping of state-approved crops on consolidated land.This dissertation, based on 13 month

We investigated the excited-state dynamics of CH3NH3PbBr3 perovskite nanoparticles (NPs) and bulk crystals under various excitation intensity regimes using transient absorption spectroscopy. We confirmed the sub-band gap hole trap states with optical transition to the conduction band in both samples. In bulk crystals, the excited-state dynamics is independent of pump intensity. However, in NPs, pr