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Spider silk is made and spun in a complex process that tightly controls the conversion from soluble protein to insoluble fiber. The mechanical properties of the silk fiber are modulated to suit the needs of the spider by various factors in the animal's spinning process. In the major ampullate (MA) gland, the silk proteins are secreted and stored in the lumen of the ampulla. A particular structural
We present a novel low-cost device for scanning object surfaces based on structured LED (Light Emitting Diode) light and a single, monocular image from a standard machine vision camera. During the calibration phase we find the displacement of the imaged LED-projected marker points as a function of depth. Using this displacement data and a suitable interpolation technique, the depth of surface poin
Structural changes of the iron(II)-tris-bipyridine ([FeII(bpy)3]2+) complex induced by ultrashort pulse excitation and population of its short-lived (0.6ns) quintet high spin state have been detected by picosecond x-ray absorption spectroscopy. The structural relaxation from the high spin to the low spin state was followed over the entire lifetime of the excited state. A combined analysis of the x
The mechanical properties of the large arteries are important determinants in the circulation physiology. Quantities associated with vessel wall elasticity are of particular interest since they offer a possibility to separate diseased arteries from healthy. Pulse wave velocity (PWV) is a local measure of the arterial wall elasticity. This paper describes a new improved method for non-invasive loca
GAD65Ab and ICA512Ab are strongly associated with insulin-dependent (Type 1) diabetes mellitus. A novel, simple radio-antigen binding assay with microSepharose conjugated with monoclonal antibodies specific for human immunoglobulin light chains was developed to provide diagnostic sensitivity and specificity of GAD65Ab and ICA512Ab for Type 1 diabetes. The Receiver Operating Characteristic (ROC) cu
This paper introduces an integrated approach for evacuation assessment of nuclear physics research facilities exposed to fire risk. The approach combines the use of a simplified egress modelling method and advanced agent-based simulations of evacuation. An integrated multi-model approach is proposed here given the varying level of complexity concerning evacuation safety in underground physics faci
BACKGROUND: Population-specificity of exploratory dietary patterns limits their generalizability in investigations with type 2 diabetes incidence. OBJECTIVE: The aim of this study was to derive country-specific exploratory dietary patterns, investigate their association with type 2 diabetes incidence, and replicate diabetes-associated dietary patterns in other countries. METHODS: Dietary intake da
The applications of femtosecond lasers to the diagnostics of combustion and flow field have recently attracted increasing interest. Many novel spectroscopic methods have been developed in obtaining non-intrusive measurements of temperature, velocity, and species concentrations with unprecedented possibilities. In this paper, several applications of femtosecond-laser-based incoherent techniques in
Employees are a crucial stakeholder group for organisations since they determinethe degree to which they achieve their goals. It is therefore necessary to build strong relationships with the workforce to encourage employee engagement, which implies that employees’ individual goals are aligned to those of the organisation. To build strong relationships, internal communication should be managed stra
Conductive Electric Road Systems (ERS) appear as a promising solution for the electrification of transportation, particularly for heavy vehicles and long-distance trips but also for light vehicles. Significant research efforts are currently devoted to the development of conductive ERS systems, with up to four pilot test sites with different technologies in operation only in Sweden. With the help o
Recent studies in neurodegenerative conditions have increasingly highlighted that the same neuropathology can trigger different clinical phenotypes or, vice-versa, that similar phenotypes can be triggered by different neuropathologies. This evidence has called for the adoption of a pathology spectrum-based approach to study neurodegenerative proteinopathies. These conditions share brain deposition
The introduction of a mollecular method to identify the Entoviruses based on the amplification sequecing and phylogenetic analysis of protein VPI was described. It was proved that this method reduces significantly the time required for the identification of the isolated Entoviruses and that it is very useful in the characterization of isolates which are difficult to typify by the routine immunoloi
OBJECTIVE: MR (mineralocorticoid receptor) activation is associated with cardiovascular ischemia in humans. This study explores the role of the MR in atherosclerotic mice of both sexes and identifies a sex-specific role for endothelial cell (EC)-MR in vascular inflammation. Approach and Results: In the AAV-PCSK9 (adeno-associated virus-proprotein convertase subtilisin/kexin type 9) mouse atheroscl
Objectives In an acute heart failure (AHF) setting, proenkephalin A 119-159 (penKid) has emerged as a promising prognostic marker for predicting worsening renal function (WRF), while bioactive adrenomedullin (bio-ADM) has been proposed as a potential marker for congestion. We examined the diagnostic value of bio-ADM in congestion and penKid in WRF and investigated the prognostic value of bio-ADM a
