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This chapter describes the background for, and implementation of, the Barnahus model within the Nordic countries. It highlights the core elements of the model and the specifics of the Nordic welfare state context relating to the child welfare and criminal justice systems. A contextual and comparative perspective is used to shed light on how the model is shaped by the legal and institutional contex
The formation of filaments from naturally occurring protein molecules is a process at the core of a range of functional and aberrant biological phenomena, such as the assembly of the cytoskeleton or the appearance of aggregates in Alzheimer's disease. The macroscopic behaviour associated with such processes is remarkably diverse, ranging from simple nucleated growth to highly cooperative processes
The malaria parasites (Apicomplexa: Haemosporida) of birds are believed to have diversified across the avian host phylogeny well after the origin of most major host lineages. Although many symbionts with direct transmission codiversify with their hosts, mechanisms of species formation in vector-borne parasites, including the role of host shifting, are poorly understood. Here, we examine the hosts
Objectives: We have observed clinical cases where bone is formed in the overlaying muscle covering surgically created bone defects treated with a hydroxyapatite/calcium sulphate biomaterial. Our objective was to investigate the osteoinductive potential of the biomaterial and to determine if growth factors secreted from local bone cells induce osteoblastic differentiation of muscle cells. Materials
This study presents a 2-yr follow-up of 281 patients, aged 15-34 yr, diagnosed with diabetes between 1992 and 1993. At diagnosis, 224 (80%) patients were positive for at least one of the following autoantibodies: islet cell antibodies (ICAs), glutamic acid decarboxylase antibodies (GADAs), or tyrosine phosphatase antibodies (IA-2As); the remaining 57 (20%) patients were negative for all three auto
The atrioventricular (AV) node plays a central role during atrial fibrillation (AF).We have recently proposed a statistical AV node model defined by parameters characterizing the arrival rate of atrial impulses, the probability of an impulse choosing the slower of the two AV nodal pathways, the refractory periods of the pathways, and the prolongation of refractory periods. All model parameters are
Denna uppsats undersöker hur Europeiska unionens öppenhet har bidragit till säkerhetspolitiska sårbarheter i relationerna till Ryssland och Kina. Med utgångspunkt i globaliseringens ökade ömsesidiga beroenden analyseras hur materiella beroenden kan utvecklas till säkerhetspolitiska risker, samt hur dessa risker språkligt förstås och legitimeras i EU:s policydiskurser. Uppsatsen genomförs som en kv
This paper presents findings from a transdisciplinary study exploring conditions for Inclusive Science Education (ISE) for children aged 0–16 from communities in vulnerability risk situation. A two-step literature review was conducted to identify inclusive teaching and learning interventions. The first phase applied a Scoping Review, followed by an Integrative Literature Review focusing on communi
Klimatförändringen kan enbart dämpas om koldioxidutsläppen reduceras till (netto) noll – till exempel genom att fossila bränslen fasas ut, cement ersätts med mer hållbara material och den globala avskogningen hejdas, tillsammans med minskade metan- och andra klimatutsläpp. Ökat utnyttjande av biomassa från jord- och skogsbruk som bioenergi och byggmaterial kan ge viktiga bidrag till detta. Men ris
During nutrient limitation, bacteria produce the alarmones (p)ppGpp as effectors of a stress signaling network termed the stringent response. RsgA, RbgA, Era, and HflX are four ribosome-associated GTPases (RA-GTPases) that bind to (p)ppGpp in Staphylococcus aureus. These enzymes are cofactors in ribosome assembly, where they cycle between the ON (GTP-bound) and OFF (GDP-bound) ribosome-associated
In the same way that the practice of cardiology has evolved over the years, so too has the way cardiology fellows in training (FITs) are trained. Propelled by recent advances in technology-catalysed by COVID-19-and the requirement to adapt age-old methods of both teaching and healthcare delivery, many aspects, or 'domains', of learning have changed. These include the environments in which FITs wor
Recent Advances: Various studies have suggested that mitochondrial DNA copy number (mtDNA-CN), a surrogate biomarker of mitochondrial dysfunction, is an easily quantifiable biomarker for chronic diseases, including diabetes and cancer. However, current knowledge is limited, and the results are controversial. This has been attributed mainly to methodology and study design.Critical Issues: The incid
Background: The demographic shift is fast becoming a global challenge. Populations ageing rapidly is widely seen as one of the most powerful transformative forces affecting society over the next four decades.Due to the demographic challenge in most countries it is important to consider making working life sustainable. It is obvious that the main factor that distinguishes senior workers from other
Evaluation of a complex healthcare intervention should include careful exploration of the mechanisms through which it brings about change. This paper describes a qualitative evaluation of the Redesigning Daily Occupations (ReDO®-10) programme as it was implemented for the first time with women with stress-related issues in a primary care setting in Ireland. The ReDO®-10 is a 10-week group interven
Lymphocytes from various lymphoid organs of WF and BN rats were isolated and stained for acid alpha-naphthyl acetate esterase (ANAE) activity. From all organs examined-peripheral blood, lymph nodes, and spleen-70-80% of the lymphocytes were stained for ANAE activity. After separation into B and non-B cells by affinity chromatography on anti-Ig columns, esterase-negative lymphocytes were detected i
The ability of lymphocytes from the peripheral blood of preterm and term infants and adult women and men to mediate natural killing (NK) and K cell activity (antibody-dependent cellular cytotoxicity) was analysed in 4 hours 51Cr-release assays. K 562 cells were targets for NK activity. K cell activity was assayed on antibody-coated rat thymocytes. Lymphocytes from adult male donors were significan
OBJECTIVE: To investigate gastrointestinal infection episodes (GIEs) in relation to the appearance of islet autoantibodies in The Environmental Determinants of Diabetes in the Young (TEDDY) cohort.RESEARCH DESIGN AND METHODS: GIEs on risk of autoantibodies against either insulin (IAA) or GAD (GADA) as the first-appearing autoantibody were assessed in a 10-year follow-up of 7,867 children. Stool vi
Att vara trans på olika sätt är ingen nödsituation och behöver inte vara dramatiskt. I stället för att enbart reagera i stunden kan politiker, rektorer, lärare, kuratorer, skolsköterskor och andra vuxna skapa en skola där färre spontana lösningar krävs eftersom det finns ett genomtänkt pedagogiskt och administrativt arbete, det som kallas ”whole-of-school approach” (Bartholomaeus & Riggs, 2017Being trans in different ways is not an emergency and does not have to be dramatic. Instead of reacting only in the moment, politicians, principals, teachers, counselors, nurses and other adults can create a school where fewer spontaneous solutions are needed because there is well thought-out pedagogical and administrative work, what is called the 'whole-of-school approach' (Bartholomaeus & Ri
Inflammasomes are large multiprotein complexes that assemble mainly in innate immune cells after detection of microbial or sterile insults. Activation of inflammasomes is a key proinflammatory event during infection, and many pathogens have evolved specific evasion mechanisms to evade or inhibit inflammasome activation. One such pathogen is the common bacterium group A Streptococcus (GAS), which c
