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Carbamylated erythropoietin (CEPO) is a novel neuroprotective agent that does not bind to the classical erythropoietin receptor or affect hematocrit. Since CEPO has not been systematically studied in a fully blinded and randomized manner in an embolic stroke model, we determined if CEPO would be useful to attenuate clinical deficits associated with multiple infarct ischemia using the rabbit small
Background: Gonadotropin-releasing hormone (GnRH), follicle-stimulating hormone (FSH), and luteinizing hormone (LH) are involved in the reproductive cycle and regulate the secretion of sex steroids from the gonads. In mammals, GnRH1 is secreted as a hormone from the hypothalamus, whereas both GnRH1 and GnRH2 are present as neuropeptides in a variety of tissues. This review describes the role of Gn
In the present work, effects of loading scheme and strain reversal on structure and hardness evolution have been studied by using high pressure torsion (HPT) and twist extrusion (TE) techniques. High purity aluminium (99.99%) was processed at room temperature up to a maximum total equivalent strain of εmax ≈ 8 by TE, and HPT in monotonic and reversal deformation modes with strain increment Δεmax =
BACKGROUND: Globally, the most common method for in situ fixation of slipped capital femoral epiphysis (SCFE) is a threaded screw, which causes physeal arrest. The standard treatment in Sweden is unthreaded fixation using the Hansson hook-pin, which leads to continued growth of the femoral neck. Our purpose was to study remodeling during the remaining growth after fixation with the Hansson hook-pi
Mice with striatal 6-hydroxydopamine (6-OHDA) lesions are widely used as a model to study the effects of neurorestorative, symptomatic, or antidyskinetic treatments for Parkinson's disease (PD). The standard praxis is to utilize young adult mice with relatively acute 6-OHDA lesions. However, long post-lesion intervals may be required for longitudinal studies of treatment interventions, and the lon
Purpose: The aim of this study is to provide evidence on the costs and health effects of two alternative hearing aid delivery models, a community-based and a centre-based approach. The study is set in Bangladesh and the study population is children between 12 and 18 years old. Methods: Data on resource use by participants and their caregivers were collected by a household survey. Follow-up data we
Background: The aim of this study was to investigate effects on perceived exertion, work ability self-reported neck pain and clinically diagnosed conditions in the neck, of an intervention with prismatic spectacles among dental personnel. Methods: In this cohort study a baseline questionnaire including questions about frequency of neck pain, perceived exertion during work and background informatio
Whole-tree harvesting, i.e. harvesting of stems, branches and tops, has become increasingly common during recent decades due to the increased demand for renewable energy. Whole-tree harvesting leads to an increase in base cation losses from the ecosystem, which can counteract recovery from acidification. An increase in weathering rates due to higher temperatures is sometimes suggested as a process
There is sufficient evidence that statins have a protective role against breast cancer proliferation and recurrence, but treatment predictive biomarkers are lacking. Breast cancer cell lines displaying diverse sensitivity to atorvastatin were subjected to global transcriptional profiling and genes significantly altered by statin treatment were identified. Atorvastatin treatment strongly inhibited
The dominance of men in politics has been a long standing trend, with women historically underrepresented in this sphere. Efforts toward women's inclusion in politics seek to address and rectify this gender imbalance, advocating for greater representation, equal opportunities, and the dismantling of barriers that have hindered women's active participation in political decision-making proce
This study examines the construction and performance of marital rites within the Modern Asatru movement, focusing on the Swedish Community of Forn Sed Sweden from 1996 to 2009. Using the newsletter Mimers Källa as the primary source, the study explores how rituals are shaped using Catherine Bell’s theories of ritual adaptivity and orthodoxy/orthopraxy. Findings reveal that these rituals are highly
Denna uppsats undersöker den fortsatta utvecklingen av ett potentiellt FN-fördrag om företag och mänskliga rättigheter. I år är det ett decennium sedan rådet för mänskliga rättigheter antog resolution 26/9, vilken inrättade en arbetsgrupp för att utarbeta ett potentiellt rättsligt bindande instrument inom mänskliga rättigheter, med målet att reglera transnationella företag och andra affärsverksamhThis thesis examines the continuing development of a potential UN Treaty on Business and Human Rights. This year marks a decade since the Human Rights Council passed resolution 26/9, establishing a working group to elaborate a potential legally binding instrument in international human rights law, with the objective to regulate the activities of transnational corporations and other business enterp
Natural hazards cannot be avoided, but their damage to what human beings value, such as life, health, and property, can be limited. Climate change will increase extreme weather events and overall disaster risk, which will particularly affect Least Developed Countries. Mainstreaming Disaster Risk Reduction (DRR) into development planning, the systematic integration of information stemming from risk
With the announcement of Energy Revolution by the government of China, and the support of policies and investments in clean and renewable energy, electric vehicles and bikes have recently been developed rapidly, which has promoted the prosperity of lead-acid battery industry and made China now the world’s leading producer, refiner, and consumer of lead-acid battery technology. However, this has cr
