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Metformin-induced suppression of Nemo-like kinase improves erythropoiesis in preclinical models of Diamond–Blackfan anemia through induction of miR-26a
Diamond–Blackfan anemia (DBA) results from haploinsufficiency of ribosomal protein subunits in hematopoietic progenitors in the earliest stages of committed erythropoiesis. Nemo-like kinase (NLK) is chronically hyperactivated in committed erythroid progenitors and precursors in multiple human and murine models of DBA. Inhibition of NLK activity and suppression of NLK expression both improve erythr
Harvesting the decay energy of 26 Al to drive lightning discharge in protoplanetary discs
Chondrules in primitive meteorites likely formed by recrystallisation of dust aggregates that were flash-heated to nearly complete melting. Chondrules may represent the building blocks of rocky planetesimals and protoplanets in the inner regions of protoplanetary discs, but the source of ubiquitous thermal processing of their dust aggregate precursors remains elusive. Here we demonstrate that esca
A novel chromosomal translocation t(3;7)(q26;q21) in myeloid leukemia resulting in overexpression of EVI1
An Improved Procedure for the Synthesis of Bicyclo[2.2.2]octane- 2,6-dione
Environmental factors influencing growth of and exopolysaccharide formation by Pediococcus parvulus 2.6
The Impact of Military Orders on the Palestinians’ Right to Water Access : a content analysis of IDF’s Military Orders regarding water in light of IHL and ICCPR Article 26
The aim of this thesis is to explore what impacts the IDF’s Military Orders regarding water have on Palestinians in the West Bank, taking international humanitarian law (IHL) and International Convention on Civil and Political Rights (ICCPR) into consideration. Thus, to discover whether or not Israel’s actions are compatible with IHL and treats everyone equal before the law, as stated in ICCPR Art
Ventilation analysis for control room in submarine A26
Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk
(μ-Acetato-κ(2) O:O')[μ-2,6-bis-({bis-[(pyri-din-2-yl-κN)meth-yl]amino-κN}meth-yl)-4-methyl-phenolato-κ(2) O:O](metha-nol-κO)dizinc bis-(perchlorate).
Influence of the mannan binding module of beta-mannanase CfMan26A in the hydrolysis of mannan
Hemicellulose is next to cellulose the most abundant polysaccharide on earth and as such an important renewable resource. Mannans are the major hemicellulose in so:ftwodd and are found as storage polysaccharide in various plants. -mannanases are the main mannan degrading enzymes. In this work the -1,4-mannanase from the soilliving bacteria Cellulosamas Jimi was studied and special focus was put on
Genetically engineered Saccharomyces cerevisiae for kinetic resolution of racemic bicyclo[3.3.1]nonane-2,6-dione
Growth and exopolysaccharide formation by Pediococcus damnosus 2.6 in beta-glucan suspensions of oat and barley
A combined experimental and theoretical study of uranium polyhydrides with new evidence for the large complex UH4(H-2)(6)
Several monouranium and diuranium polyhydride molecules were investigated using quantum chemical methods. The infrared spectra of uranium and hydrogen reaction products in condensed neon and pure hydrogen were measured and compared with previous argon matrix frequencies. The calculated molecular structures and vibrational frequencies were used to identify the species present in the matrix. Major n